Monthly Archives: March 2012

Pain affect in the absence of pain sensation: evidence of asomaesthesia after somatosensory cortex lesions in the rat.

Pain. 2012 Feb 23. [Epub ahead of print]Pain affect in the absence of pain sensation: evidence of asomaesthesia after somatosensory cortex lesions in the rat.Uhelski ML, Davis MA, Fuchs PN.Source Department of Diagnostic and Biological Sciences, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.Abstract Multidimensional models of pain processing distinguish the sensory, motivational, and affective components of the pain experience. Efforts to understand underlying mechanisms have focused on isolating the roles of specific brain structures, including both limbic and non-limbic cortical areas, in the processing … Continue reading

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Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults.

Ann Neurol. 2011 Sep 2. doi: 10.1002/ana.22620. [Epub ahead of print]Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults.Hagberg H, Gressens P, Mallard C.Source Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom. henrik.hagberg@obgyn.gu.se.Abstract Inflammation is increasingly recognized as being of both physiological and pathological importance in the immature brain. The rationale of this review is to present … Continue reading

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Psychosocial stress and cardiovascular risk : current opinion.

Swiss Med Wkly. 2012 Jan 20;142:0. doi: 10.4414/smw.2012.13502.Psychosocial stress and cardiovascular risk : current opinion.von Känel R.Source Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, and University of Bern, Switzerland. roland.vonkaenel@insel.chAbstract Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Epidemiologic research of the last half-century has clearly shown that psychosocial factors related to the social environment, personality characteristics, and negative affect increase the risk of incident CVD and also impact prognosis of cardiac patients. Several mechanisms … Continue reading

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The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults.

Nutr J. 2011 Oct 20;10:117. The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. Danthiir V, Burns NR, Nettelbeck T, Wilson C, Wittert G. Source Preventative Health Research Flagship, Commonwealth Scientific and Industrial Research Organisation – Food and Nutritional Sciences, Adelaide, South Australia, Australia. vanessa.danthiir@csiro.au Abstract BACKGROUND: Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids … Continue reading

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Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior.

Neuropsychopharmacology. 2012 Jan;37(1):137-62. doi: 10.1038/npp.2011.205. Epub 2011 Sep 14.Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior.Haroon E, Raison CL, Miller AH.Source Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.Abstract The potential contribution of chronic inflammation to the development of neuropsychiatric disorders such as major depression has received increasing attention. Elevated biomarkers of inflammation, including inflammatory cytokines and acute-phase proteins, have been found in depressed patients, and administration of inflammatory stimuli has been associated with … Continue reading

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Inflammatory mechanisms in major depressive disorder.

Curr Opin Psychiatry. 2011 Nov;24(6):519-25.Inflammatory mechanisms in major depressive disorder.Raedler TJ.Source Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. thomas.raedler@albertahealthservices.caAbstractPURPOSE OF REVIEW: As the ‘monoamine hypothesis of depression’ fails to explain all aspects of major depression, additional causes are being investigated. Several observations suggest that inflammatory mechanisms pay a role in the cause of major depressive disorder (MDD). This article reviews their role in major depression.RECENT FINDINGS: Recent studies support the concept that inflammatory mechanisms play a crucial role in the … Continue reading

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Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial.

Brain Behav Immun. 2011 Nov;25(8):1725-34. Epub 2011 Jul 19.Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial.Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R.Source Institute for Behavioral Medicine Research, Ohio State University College of Medicine, OH 43210, USA. Janice.Kiecolt-Glaser@osumc.eduAbstract Observational studies have linked lower omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and higher omega-6 (n-6) PUFAs with inflammation and depression, but randomized controlled trial (RCT) data have been mixed. To determine whether n-3 decreases proinflammatory cytokine production and depressive and … Continue reading

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Pro- and anti-inflammatory cytokines expression in rat’s brain and spleen exposed to chronic mild stress: involvement in depression.

Behav Brain Res. 2011 Nov 20;225(1):135-41. Epub 2011 Jul 8.Pro- and anti-inflammatory cytokines expression in rat’s brain and spleen exposed to chronic mild stress: involvement in depression.You Z, Luo C, Zhang W, Chen Y, He J, Zhao Q, Zuo R, Wu Y.Source Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China. youzili@uestc.edu.cnAbstract The association between pro-inflammatory cytokines and depression has been reported by many studies. However, the mechanisms by … Continue reading

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Inflammatory biomarkers in depression: an opportunity for novel therapeutic interventions.

Curr Psychiatry Rep. 2011 Oct;13(5):316-20.Inflammatory biomarkers in depression: an opportunity for novel therapeutic interventions.Li M, Soczynska JK, Kennedy SH.Source Psychosocial Oncology and Palliative Care, University Health Network/Princess Margaret Hospital and University of Toronto, Toronto, ON M5G 2M9, Canada. madeline.li@uhn.on.caAbstract Currently available antidepressants are effective in less than two thirds of depressed patients, with even lower remission rates in the context of co-morbid medical illness. A rapidly expanding evidence base suggests that maladaptive inflammatory immune responses may be a common pathophysiology underlying depression, particularly in the … Continue reading

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Inflammation and depression: why poststroke depression may be the norm and not the exception.

Int J Stroke. 2011 Apr;6(2):128-35. doi: 10.1111/j.1747-4949.2010.00565.x. Epub 2011 Jan 19.Inflammation and depression: why poststroke depression may be the norm and not the exception.Pascoe MC, Crewther SG, Carey LM, Crewther DP.Source Brain Sciences Institute, Swinburne University, Melbourne, Vic, Australia.Abstract Ischaemic stroke often precedes the appearance of clinical depression. Poststroke depression in turn influences the prognostic outcome. In the interest of advancing our understanding of the biological mechanisms underlying the development of poststroke depression, this systematic review explores the immunological processes driving the development of inflammation-related … Continue reading

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Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders.

Brain Behav Immun. 2011 Jun;25 Suppl 1:S13-20. Epub 2010 Dec 28.Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders.Kelley KW, Dantzer R.Source Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. kwkelley@illinois.eduAbstract Alcohol abuse changes behavior and can induce major mood disorders such as depression. Recent evidence in pre-clinical rodent models and humans now supports the conclusion that the innate immune system is an important physiological link between alcoholism and major depressive disorders. … Continue reading

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Immune activation by casein dietary antigens in bipolar disorder.

Bipolar Disord. 2010 Dec;12(8):834-42. doi: 10.1111/j.1399-5618.2010.00879.x.Immune activation by casein dietary antigens in bipolar disorder.Severance EG, Dupont D, Dickerson FB, Stallings CR, Origoni AE, Krivogorsky B, Yang S, Haasnoot W, Yolken RH.Source Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA. eseverance@jhmi.eduAbstractOBJECTIVES:   Inflammation and other immune processes are increasingly linked to psychiatric diseases. Antigenic triggers specific to bipolar disorder are not yet defined. We tested whether antibodies to bovine milk caseins were associated with bipolar … Continue reading

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