Monthly Archives: February 2013

Scourge of depression sees rising number of suicides, report Cang Wei and Song Wenwei in Nanjing.

Staggering base rate… Dark days of despair drive many to the final option Updated: 2013-02-27 09:20 By Cang Wei and Song Wenwei in Nanjing/China Daily Scourge of depression sees rising number of suicides, report Cang Wei and Song Wenwei in Nanjing. Every three minutes, a person suffering from depression commits suicide in China and a further 11 people attempt to take their own lives.Every year in China, 287,000 people end their lives by suicide, while another 2 million contemplate the act, 70 percent of them … Continue reading

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How the FDA forgot the evidence: the case of donepezil 23 mg | BMJ

BMJ Observations Not So Stories How the FDA forgot the evidence: the case of donepezil 23 mg BMJ 2012; 344 doi: http://dx.doi.org.ezproxy.cul.columbia.edu/10.1136/bmj.e1086 (Published 22 March 2012) Cite this as: BMJ 2012;344:e1086 Lisa M Schwartz, professor12, Steven Woloshin, professor12 Author Affiliations Steven.Woloshin@dartmouth.edu In the first of a new occasional series highlighting the exaggerations, distortions, and selective reporting that make some news stories, advertising, and medical journal articles “not so,” Lisa M Schwartz and Steven Woloshin challenge the claims made for the new 23 mg dose of … Continue reading

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The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy.

Front Neurosci. 2012;6:33. doi: 10.3389/fnins.2012.00033. Epub 2012 Mar 26. The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy. Ruskin DN, Masino SA. Source Neuroscience Program, Department of Psychology, Trinity College Hartford, CT, USA. Abstract A link between metabolism and brain function is clear. Since ancient times, epileptic seizures were noted as treatable with fasting, and historical observations of the therapeutic benefits of fasting on epilepsy were confirmed nearly 100 years ago. Shortly thereafter a high fat, low-carbohydrate ketogenic diet (KD) debuted as … Continue reading

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Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.

PLoS One. 2009 Dec 23;4(12):e8349. doi: 10.1371/journal.pone.0008349. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. Ruskin DN, Kawamura M, Masino SA. Source Department of Psychology and Neuroscience Program, Trinity College, Hartford, Connecticut, United States of America. Abstract The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes, and recent basic research provides evidence that ketogenic strategies … Continue reading

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Panic Developments – An Interesting Editorial by Donald F. Klein in the Revista Brasileira de Psiquiatria

Revista Brasileira de Psiquiatria 2012;34(Supl1):S01-S04 Panic Developments This editorial permits personal conclusions and questions, hoping to stimulate relevant research. Klein, in 1959, serendipitously found that imipramine blocked the apparently spontaneous panic attack in non-depressed inpatients, later considered agoraphobic.Later it was found that these specific anti-panic drugs blocked lactate challenges, although low potency benzodiazepines and beta-blockers did not. Also, panic patients with early onset, frequently had a history of severe separation anxiety disorder, often manifested as school phobia. A series of usually post-pubertal panics led to … Continue reading

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