Monthly Archives: August 2013

Expanding Disease Definitions in Guidelines and Expert Panel Ties to Industry: A Cross-sectional Study of Common Conditions in the United States

From the Editor’s Summary: “The researchers identified 16 publications in which expert panels proposed changes to the disease definitions and diagnostic criteria for 14 conditions that are common in the US such as hypertension (high blood pressure) and Alzheimer disease. The proposed changes widened the disease definition for ten diseases, narrowed it for one disease, and had an unclear impact for five diseases. Reasons included in the publications for changing disease definitions included new evidence of risk for people previously considered normal (pre-hypertension) and the emergence of new biomarkers, tests, or treatments (Alzheimer disease). Only six of the panels mentioned possible harms of the proposed changes and none appeared to rigorously assess the downsides of expanding definitions. Of the 15 panels involved in the publications (one panel produced two publications), 12 included members who disclosed financial ties to multiple companies. Notably, the commonest industrial ties among these panels were to companies marketing drugs for the disease being considered by that panel. On average, 75% of panel members disclosed industry ties (range 0% to 100%) to a median of seven companies each. Moreover, similar proportions of panel members disclosed industry ties in publications released before and after the 2011 IOM report.” Continue reading

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Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults.

12. J Am Geriatr Soc. 2009 May;57(5):871-6. Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults. Ng TP, Feng L, Niti M, Kua EH, Yap KB. Source Gerontological Research Programme, National University of Singapore, Department of Psychological Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore. pcmngtp@nus.edu.sg Abstract OBJECTIVES: To investigate the independent associations between folate, B12, and homocysteine levels and depressive symptoms in older adults. DESIGN: Cross-sectional study. SETTING: Resident population in southeast Singapore. PARTICIPANTS: Six … Continue reading

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Singapore: Lower dementia prevalence among ethnic Chinese compared to ethnic Malays and Indians.

Dement Geriatr Cogn Disord. 2010;30(6):492-8. doi: 10.1159/000321675. Epub 2011 Jan 20. Interethnic differences in dementia epidemiology: global and Asia-Pacific perspectives. Venketasubramanian N, Sahadevan S, Kua EH, Chen CP, Ng TP. Source Division of Neurology, University Medicine Cluster, and Department of Epidemiology and Public Health, National University Health System, National University of Singapore, 1E Kent Ridge Road, Singapore. ramani_nv@nuhs.edu.sg Abstract The burden of dementia will continue to rise globally, particularly in developing countries, many of which lie in the Asia-Pacific region. It was initially thought that … Continue reading

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Tea drinking and cognitive function in oldest-old Chinese.

J Nutr Health Aging. 2012;16(9):754-8. doi: 10.1007/s12603-012-0077-1. Tea drinking and cognitive function in oldest-old Chinese. Feng L, Li J, Ng TP, Lee TS, Kua EH, Zeng Y. Source Department of Psychological Medicine, National University of Singapore. pcmfl@nus.edu.sg Abstract OBJECTIVE: We examined the longitudinal association between tea drinking frequency and cognitive function in a large sample of oldest-old Chinese. DESIGN: population-based longitudinal cohort study. SETTING: The Chinese Longitudinal Healthy Longevity Survey (CLHLS). PARTICIPANTS: 7139 participants aged 80 to 115 (mean age 91.4 years) who provided complete … Continue reading

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Life event stress and chronic obstructive pulmonary disease (COPD)

BMJ Open. 2012 Nov 19;2(6). pii: e001674. doi: 10.1136/bmjopen-2012-001674. Print 2012. Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study. Lu Y, Nyunt MS, Gwee X, Feng L, Feng L, Kua EH, Kumar R, Ng TP. Source Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Abstract OBJECTIVES: To investigate whether life event stress was associated with greater psychological distress and poorer quality of life in older … Continue reading

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Allen Frances on Bloomberg.com: How Many Billions a Year Will the DSM-5 Cost?

Allen Frances on Bloomberg.com: How Many Billions a Year Will the DSM-5 Cost? Bloomberg.com Businessweek.com Bloomberg TV Premium Register Sign In Bloomberg View Our Company Professional Anywhere How Many Billions a Year Will the DSM-5 Cost? By Allen Frances Dec 20, 2012 6:30 PM ET Facebook Share Tweet LinkedIn Google +1 COMMENTS Print QUEUE In preparing the DSM-5, the revised manual that is to be the next bible of psychiatric diagnosis, the American Psychiatric Association has been extravagantly indifferent to all matters of cost. There … Continue reading

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Finasteride induced depression: a prospective study.

Finasteride induced depression: a prospective study. Rahimi-Ardabili B, Pourandarjani R, Habibollahi P, Mualeki A. Source Clinical Pharmacy Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ba.rahimi@gmail.com Abstract BACKGROUND: Finasteride is a competitive inhibitor of 5 alpha-reductase enzyme, and is used for treatment of benign prostatic hyperplasia and androgenetic alopecia. Animal studies have shown that finasteride might induce behavioral changes. Additionally, some cases of finasteride-induceddepression have been reported in humans. The purpose of this study was to examine whether depressive symptoms or anxiety might be induced byfinasteride administration. METHODS: One hundred and twenty eight men … Continue reading

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Finasteride treatment influences neuronal plasticity on a structural level. These changes might contribute to the pathophysiology of depressive episodes observed after finasteride treatment.

Pharmacopsychiatry. 2010 Jul;43(5):174-8. doi: 10.1055/s-0030-1249095. Epub 2010 May 18. Finasteride treatment inhibits adult hippocampal neurogenesis in male mice. Römer B, Pfeiffer N, Lewicka S, Ben-Abdallah N, Vogt MA, Deuschle M, Vollmayr B, Gass P. Source RG Behavioural Biology, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany. benedikt.roemer@zi-mannheim.de Abstract INTRODUCTION: The 5-alpha-reductase inhibitor finasteride is used for the treatment of androgenic alopecia, benign prostate hyperplasia and prostate cancer. Besides inhibiting the conversion of testosterone to the biologically more active 5alpha-dihydrotestosterone, it also inhibits the production of neurosteroids. Decreased neurosteroid levels are postulated to be involved … Continue reading

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