Monthly Archives: September 2013

Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American

Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American. Highly recommended reading. As it turns out, one does not have to go all the way down the evolutionary ladder to be reminded that even brain-impaired or brain-damaged individuals (whether through TBI, dementia, various levels of unconsciousness, or simply sleep) have not only memories, but continue to experience emotions, good and bad. As an illustration that the brain is made of many different levels and parts, here is a recent paper by Feinstein et … Continue reading

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Metabolic Fate of Pharmaceuticals: A Focus on Slow Metabolizers

Very interesting and timely PowerPoint focusing on (now increasingly preventable) adverse outcomes, not on metabolism-related lack of efficacy. >>It has been shown that variability in drug metabolism can have a substantial effect on clinical outcomes in patients. The impact of such variability in inter-individual responsiveness to the same dose of a given drug has historically received considerable attention. Drug metabolism is affected by numerous factors of both environmental and genetic origin. Recently, increased attention has been given to the genetic factors that may affect drug … Continue reading

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The Pros and Cons of Concierge Medical Care | NYCityWoman.com

The Pros and Cons of Concierge Medical Care | NYCityWoman.com A thoughtful and balanced, and (yes) enthusiastic discussion of what it means to have a personal physician in U.S.A. anno 2013. Written by Sally Wendkos Olds, happy patient of Margaret Lewin, MD, a member of IDNY. The full text is here: The Pros and Cons of Concierge Medical Care | NYCityWoman.com. Well worth your reading time.  

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Simvastatin impairs exercise training adaptations.

Simvastatin impairs exercise training adaptations. Mikus CR, et al. Show all J Am Coll Cardiol. 2013 Aug 20;62(8):709-14. doi: 10.1016/j.jacc.2013.02.074. Epub 2013 Apr 10. Affiliation Division of Cardiology, Duke University Medical Center, Durham, North Carolina. Abstract OBJECTIVES: This study sought to determine if simvastatin impairs exercise training adaptations. BACKGROUND: Statins are commonly prescribed in combination with therapeutic lifestyle changes, including exercise, to reduce cardiovascular disease risk in patients with metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired mitochondrial function, but … Continue reading

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Among well-functioning older adults, DM and poor glucose control among those with DM are associated with worse cognitive function and greater decline. This suggests that severity of DM may contribute to accelerated cognitive aging.

Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. Yaffe K, et al. Show all Arch Neurol. 2012 Sep;69(9):1170-5. doi: 10.1001/archneurol.2012.1117. Affiliation Departments of Psychiatry, University of California, San Francisco, and San Francisco, VA, USA. kristine.yaffe@ucsf.edu Abstract OBJECTIVES: To determine if prevalent and incident diabetes mellitus (DM) increase risk of cognitive decline and if, among elderly adults with DM, poor glucose control is related to worse cognitive performance. DESIGN Prospective cohort study. SETTING: Health, Aging, and Body Composition Study at 2 community … Continue reading

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Long-term use of statins may be associated with increased risks of both ductal and lobular breast cancer among women 55-74 years of age

Search Home PDF Current Issue Past Issues OnlineFirst Long-term statin use and risk of ductal and lobular breast cancer among women 55-74 years of age  Authors Abstract Background: Mechanistic studies largely support the chemopreventive potential of statins. However, results of epidemiologic studies investigating statin use and breast cancer risk have been inconsistent and lacked the ability to evaluate long-term statin use. Methods: We utilized data from a population-based case-control study of breast cancer conducted in the Seattle-Puget Sound region to investigate the relationship between long-term … Continue reading

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China ‘Catastrophe’ Hits 114 Million as Diabetes Spreads

Given the link between DM II and dementia, previous estimates of China’s coming dementia burden may need to be adjusted. See also: http://psychiatryneurology.net/news/time-to-confront-the-global-dementia-crisis-the-lancet-neurology/ >>The most comprehensive nationwide survey for diabetes ever conducted in China shows 11.6 percent of adults, or 114 million, has the disease. The finding, published yesterday in the Journal of the American Medical Association, adds 22 million diabetics, or the population of Australia, to a 2007 estimate and means almost one in three diabetes sufferers globally is in China.<< [Full text at … Continue reading

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