Monthly Archives: June 2015

Neuroprotective and disease-modifying effects of the ketogenic diet

Behav Pharmacol. 2006 Sep; 17(5-6): 431–439.  PMCID: PMC2367001 NIHMSID: NIHMS42857 Neuroprotective and disease-modifying effects of the ketogenic diet Maciej Gasior,a Michael A. Rogawski,a and  Adam L. Hartmana,b Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Behav Pharmacol See other articles in PMC that cite the published article. Go to: Abstract The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer … Continue reading

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Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects.

Neurology. 2005 May 24;64(10):1704-11. Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Enzinger C1, Fazekas F, Matthews PM, Ropele S, Schmidt H, Smith S, Schmidt R. Author information Abstract OBJECTIVES: To determine the rate of brain atrophy in neurologically asymptomatic elderly and to investigate the impact of baseline variables including conventional cerebrovascular risk factors, APOE epsilon4, and white matter hyperintensity (WMH) on its progression. METHODS: We assessed the brain parenchymal fraction at baseline and subsequent annual brain volume changes over 6 years for 201 participants (F/M … Continue reading

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Hyperglycemia is associated with subtle brain injury and impaired attention and memory even in young adults

Neurology. 2015 Jun 9;84(23):2329-37. doi: 10.1212/WNL.0000000000001655. Epub 2015 May 6. Glucose indices are associated with cognitive and structural brain measures in young adults. Weinstein G1, Maillard P2, Himali JJ2, Beiser AS2, Au R2, Wolf PA2, Seshadri S2, DeCarli C2. Author information Abstract OBJECTIVE: To evaluate the possible early consequences of impaired glucose metabolism on the brain by assessing the relationship of diabetes, fasting blood glucose (FBG) levels, and insulin resistance with cognitive performance and brain integrity in healthy young and middle-aged adults. METHODS: The sample included dementia-free participants (mean age 40 ± 9 … Continue reading

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Association between benzodiazepine use and occurrence of benign brain tumors.

J Neurol Sci. 2014 Jan 15;336(1-2):8-12. doi: 10.1016/j.jns.2013.11.009. Epub 2013 Nov 16. An association between benzodiazepine use and occurrence of benign brain tumors. Harnod T1, Lin CL2, Sung FC2, Kao CH3. Author information Abstract OBJECTIVE: This study was designed to evaluate the impact of long-term benzodiazepine use on the subsequent risk of benign brain tumor (BBT) or malignant brain tumor (MBT) development. METHOD: We used data from the National Health Insurance System of Taiwan. For the study cohort, we identified 62,186 patients who had been prescribed benzodiazepine for at least 2 … Continue reading

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Endogenous opiate high through exercise and pickled cabbage?

An endogenous opiate high through exercise and pickled cabbage? Psychiatry Res. 2015 Aug 15;228(2):203-8. doi: 10.1016/j.psychres.2015.04.023. Epub 2015 Apr 28. Fermented foods, neuroticism, and social anxiety: An interaction model. Hilimire MR1, DeVylder JE2, Forestell CA3. Author information Abstract Animal models and clinical trials in humans suggest that probiotics can have an anxiolytic effect. However, no studies have examined the relationship between probiotics and social anxiety. Here we employ a cross-sectional approach to determine whether consumption of fermented foods likely to contain probiotics interacts with neuroticism to predict social anxiety symptoms. A sample of young adults (N=710, 445 female) completed self-report measures of fermented food consumption, neuroticism, and social anxiety. … Continue reading

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Variants in Antiviral Genes are Risk Factors for Cognitive Decline and Dementia.

J Alzheimers Dis. 2015 Apr 2. [Epub ahead of print] Variants in Antiviral Genes are Risk Factors for Cognitive Decline and Dementia. Licastro F1, Raschi E1, Carbone I1, Porcellini E1. Author information Abstract A gene association study of factors regulating antiviral response such as interferon (IFN)-λ3, also known as IL-28B, mediator complex (Med) 23, and interferon regulatory factor (IRF) 7 with cognitive deterioration and Alzheimer’s disease (AD) was performed. Differences in the TT genotype distribution of IL-28B single nucleotide polymorphism (SNP) between AD patients and controls were found. The GG … Continue reading

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HSV and Alzheimer’s Dementia – first described 40 years ago.

Acta Virol. 1975 Nov;19(6):493-5. Search for herpetic antibodies in the cerebrospinal fluid in senile dementia and mental retardation. Libíková H, Pogády J, Wiedermann V, Breier S. Abstract Complement-requiring neutralizing antibodies to herpes simplex type 1 virus (HSV 1) in titres from 2 to greater than 16 were detected in the cerebrospinal fluid (CSF) of 47% senile patients with various forms of dementia, but in none of mentally retarded adolescents and adults suffering from various neurologidal diseases. Also the incidence of HSV 1 serum antibodies in elevated titres (larger than or equal to 512) was increased … Continue reading

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More on HSV and Alzheimer’s Disease

Alzheimers Dement. 2013 Mar;9(2):169-75. doi: 10.1016/j.jalz.2012.07.005. Epub 2012 Nov 14. Intracerebral propagation of Alzheimer’s disease: strengthening evidence of a herpes simplex virus etiology. Ball MJ1, Lukiw WJ, Kammerman EM, Hill JM. Author information Abstract BACKGROUND: A faulty human protein, abnormally phosphorylated tau, was recently publicized to spread “like a virus” from neuron to neuron in Alzheimer’s patients’ brains. For several decades, we have been amassing arguments showing that herpes simplex virus type 1 (HSV-1), not p-tau, propagates this interneuronal, transsynaptic pathologic cascade. METHODS: We reiterate convincing data from our … Continue reading

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Titers of herpes simplex virus type 1 antibodies positively correlate with grey matter volumes in Alzheimer’s disease.

There are safe and effective treatments for these common viruses. Why aren’t they used in mainstream, neurology? J Alzheimers Dis. 2014;38(4):741-5. doi: 10.3233/JAD-130977. Titers of herpes simplex virus type 1 antibodies positively correlate with grey matter volumes in Alzheimer’s disease. Mancuso R1, Baglio F, Cabinio M, Calabrese E, Hernis A, Nemni R, Clerici M. Author information Abstract HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer’s disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild … Continue reading

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How plausible is a link between HSV-1 infection and Alzheimer’s disease?

Expert Rev Anti Infect Ther. 2014 Mar;12(3):275-8. doi: 10.1586/14787210.2014.887442. Epub 2014 Feb 6. How plausible is a link between HSV-1 infection and Alzheimer’s disease? Agostini S1, Clerici M, Mancuso R. Author information Abstract Alzheimer’s disease is a leading cause of dementia with a multifactorial and still barely understood etiology. A growing body of epidemiologic and experimental data support a role for infectious agents in this process; herpes simplex virus 1 (HSV-1), in particular, is a strong suspect. We briefly summarize the data pointing at a pathogenic role for HSV-1 in the development … Continue reading

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Reactivated herpes simplex infection increases the risk of Alzheimer’s disease.

Alzheimers Dement. 2014 Jul 17. pii: S1552-5260(14)02421-2. doi: 10.1016/j.jalz.2014.04.522. [Epub ahead of print] Reactivated herpes simplex infection increases the risk of Alzheimer’s disease. Lövheim H1, Gilthorpe J2, Adolfsson R3, Nilsson LG4, Elgh F5. Author information Abstract BACKGROUND: Previous studies have suggested a link between herpes simplex virus (HSV) type 1 and the development of Alzheimer’s disease (AD). METHODS: The present analysis included 3432 persons (53.9% women, mean age at inclusion 62.7 ± 14.4 years) with a mean follow-up time of 11.3 years. The number of incident AD cases was 245. Serum samples were analyzed for anti-HSV antibodies … Continue reading

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CMV infection may be associated with an increased risk of Alzheimer Disease

Cytomegalovirus (CMV) infection may be associated with an increased risk of Alzheimer Disease. J Infect Dis. 2015 Jan 15;211(2):230-7. doi: 10.1093/infdis/jiu437. Epub 2014 Aug 8. Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals. Barnes LL1, Capuano AW2, Aiello AE3, Turner AD4, Yolken RH5, Torrey EF5, Bennett DA2. Author information Abstract BACKGROUND: Human cytomegalovirus (CMV) is prevalent in older adults and has been implicated in many chronic diseases of aging. This study investigated the relation between CMV and the risk of Alzheimer disease (AD). METHODS: Data come from … Continue reading

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