Monthly Archives: January 2016

True Risk of Serious Harms with Antidepressants Still Uncertain

True Risk of Serious Harms with Antidepressants Still Uncertain http://www.bmj.com/content/352/bmj.i65 Abstract Objective To study serious harms associated with selective serotonin and serotonin-norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main outcome measures Mortality and suicidality. Secondary outcomes were aggressive behaviour and akathisia. Data sources Clinical study reports for duloxetine, fluoxetine, paroxetine, sertraline, and venlafaxine obtained from the European and UK drug regulators, and summary trial reports for duloxetine and fluoxetine from Eli Lilly’s website. Eligibility criteria for study selection Double blind placebo controlled trials that contained any patient narratives or … Continue reading

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Quetiapine safety in older adults?

Quetiapine safety in older adults? Journal of Clinical Pharmacy and Therapeutics Volume 41,  Issue 1, pages 7–18, February 2016 http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12357/abstract Abstract WHAT IS KNOWN AND OBJECTIVE: Quetiapine is a second-generation antipsychotic that is commonly prescribed for a range of approved and off-label indications in older adults. However, little is known about its safety in this population. The available evidence on quetiapine safety is based on studies on second-generation antipsychotics as a group, often in the general population and for approved indications. There are no systematicreviews on the safety … Continue reading

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Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition.

  Richard Carlton MD asked me to post abstracts related to the well-established but under-appreciated dopamine-blocking effect of metoclopramide. Ned Tijdschr Geneeskd. 2013;157(26):A6037. Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition. [Article in Dutch] de Ronde MW1, Kingma HJ, Munts AG. Author information 1Kennemer Gasthuis, afd. Neurologie, Haarlem, the Netherlands. mwjderonde@gmail.com Abstract In this article, we present 3 women aged 73, 85 and 88 years who developed metoclopramide-induced parkinsonism. Shortly after starting metoclopramide, bradykinesia and rigidity developed in all 3 patients; tremor and postural instability … Continue reading

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A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-28 Ingrid Van der Auwera, Stefaan Wera, Fred Van Leuven and Samuel T HendersonEmail author Nutrition & Metabolism20052:28 DOI: 10.1186/1743-7075-2-28 ©  Van der Auwera et al; licensee BioMed Central Ltd. 2005 Received: 09 August 2005 Accepted: 17 October 2005 Published: 17 October 2005 Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and development of AD. Yet, these studies did … Continue reading

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Neuroprotective and disease-modifying effects of the ketogenic diet

Neuroprotective and disease-modifying effects of the ketogenic diet Behav Pharmacol. Author manuscript; available in PMC 2008 May 5. Published in final edited form as: Behav Pharmacol. 2006 Sep; 17(5-6): 431–439. Reading it again.. Well worth it. Abstract The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer long-lasting therapeutic benefits for patients with epilepsy. Moreover, there is evidence from uncontrolled … Continue reading

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Crowdsourcing Diagnosis for Patients With Undiagnosed Illnesses: An Evaluation of CrowdMed

Crowdsourcing Diagnosis for Patients With Undiagnosed Illnesses: An Evaluation of CrowdMed http://www.jmir.org/2016/1/e12/   Ashley N.D Meyer1,2, PhD ; Christopher A Longhurst3, MD, MS ; Hardeep Singh1,2, MD, MPH  1Houston Veterans Affairs Center for Innovations in Quality, Effectiveness and Safety, Health Services Research and Development, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, United States 2Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX, United States 3Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, United States Corresponding Author: … Continue reading

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Risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy

The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: A systematic review and meta-analysis   http://onlinelibrary.wiley.com/doi/10.1111/bcp.12849/abstract Anick Bérard1,2,*, Noha Iessa1,2, Sonia Chaabane1,2, Flory T. Muanda1,2, Takoua Boukhris1,2 and Jin-Ping Zhao1,2 DOI: 10.1111/bcp.12849 This article is protected by copyright. All rights reserved. Issue British Journal of Clinical Pharmacology Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) Additional Information(Show All) Author InformationPublication History This article has been accepted for … Continue reading

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Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men

  http://link.springer.com/article/10.1007/s00125-015-3846-7 Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men Casey Crump  , Jan Sundquist , Marilyn A. Winkleby , Kristina Sundquist $39.95 / €34.95 / £29.95 * * Final gross prices may vary according to local VAT. Get Access Abstract Aims/hypothesis Psychosocial stress in adulthood is associated with a higher risk of type 2 diabetes, possibly mediated by behavioural and physiological factors. However, it is unknown whether low stress resilience earlier in life is related to subsequent development of type 2 diabetes. We examined whether low … Continue reading

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Cognitive effects of intentional weight loss in elderly obese individuals with mild cognitive impairment

  http://press.endocrine.org/doi/abs/10.1210/jc.2015-2315 Cognitive effects of intentional weight loss in elderly obese individuals with mild cognitive impairment Nidia Celeste Horie1, Valeria T Serrao2, Sharon Sanz Simon3, Maria Rita Polo Gascon2, Alessandra Xavier dos Santos4, Maria Aquimara Zambone4, Marta Merenciana del Bigio de Freitas5, Edecio Cunha-Neto6, Emerson Leonildo Marques1, Alfredo Halpern1, Maria Edna de Melo1, Marcio C Mancini1, and Cintia Cercato1 Address all correspondence and requests for reprints to: Dr.Nidia Celeste Horie Ph.D. nidiachorie@yahoo.com.br Faculdade de Medicina da Universidade de São Paulo – Endocrinology R Dr Ené as de Carvalho Aguiar, 155 8andar, Endocrinologia Sao Paulo SP BRAZIL 05403–000 55–011–99640 … Continue reading

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Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease http://archinte.jamanetwork.com/article.aspx?articleid=2481157 Benjamin Lazarus, MBBS1,2; Yuan Chen, MS1; Francis P. Wilson, MD, MS3; Yingying Sang, MS1; Alex R. Chang, MD, MS4; Josef Coresh, MD, PhD1,5; Morgan E. Grams, MD, PhD1,5 [+] Author Affiliations JAMA Intern Med. Published online January 11, 2016. doi:10.1001/jamainternmed.2015.7193 Text Size: A A A ABSTRACT ABSTRACT | INTRODUCTION | METHODS | RESULTS | DISCUSSION | CONCLUSIONS |ARTICLE INFORMATION | REFERENCES Importance  Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI use and chronic kidney disease (CKD). Objective  To quantify the association between PPI use and … Continue reading

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Erectile dysfunction? – Eat berries!

http://ajcn.nutrition.org/content/early/2016/01/06/ajcn.115.122010.abstract Dietary flavonoid intake and incidence of erectile dysfunction1 Aedín Cassidy2,  Mary Franz3, and Eric B Rimm3–6* +Author Affiliations 2Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom; 3Departments of Nutrition and 4Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; and 5Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital; and 6Harvard Medical School, Boston, MA +Author Notes ↵1 Supported by research grants CA55075, HL35464, and UM1 CA167552 from the NIH and the Biotechnology and Biological Sciences … Continue reading

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