Monthly Archives: February 2016

Recognizing and preventing epilepsy-related mortality

Recognizing and preventing epilepsy-related mortality http://tinyurl.com/gp8oojy Orrin Devinsky, MD, Tanya Spruill, PhD, David Thurman, MD, PhD and Daniel Friedman, MD, MSc +SHOW AFFILIATIONS | + SHOW FULL DISCLOSURES Correspondence to Dr. Devinsky: od4@nyu.edu Published online before print December 16, 2015doi:http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000002253Neurology February 23, 2016 vol. 86 no. 8 779-786 ABSTRACT Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, … Continue reading

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Cause of death and predictors of mortality in a community-based cohort of people with epilepsy

Cause of death and predictors of mortality in a community-based cohort of people with epilepsy http://tinyurl.com/hdbgazx Mark R. Keezer, MDCM, MSc, FRCP(C), Gail S. Bell, MB, ChB, MD, Aidan Neligan, PhD, MRCP, Jan Novy, MD, PhD and Josemir W. Sander, MD, PhD, FRCP +SHOW AFFILIATIONS| + SHOW FULL DISCLOSURES Correspondence to Dr. Sander: l.sander@ucl.ac.uk Published online before print January 15, 2016doi:http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000002390Neurology February 23, 2016 vol. 86 no. 8 704-712 ABSTRACT Objective: The risk of premature mortality is increased in people with epilepsy. The reasons for this and how it … Continue reading

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Association between sleep disorders and injury: a nationwide population-based retrospective cohort study

Association between sleep disorders and injury: a nationwide population-based retrospective cohort study http://tinyurl.com/z3ta5z2 Chia-Ling Lin1,2, Chi-Hsiang Chung3, Yu-Hsia Tsai1,4, Wu-Chien Chien5,6 Author Affiliations 1School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan 2Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan 3Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan 4Department of Nursing, College of Medicine, Chang Gung University, Taoyuan, Taiwan 5Department of Medical Research, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan 6School of Public Health, National Defense Medical Center, … Continue reading

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Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996–2013

Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996–2013 http://tinyurl.com/jqlst3n Marcus A. Bachhuber, MD, MSHP, Sean Hennessy, PharmD, PhD, Chinazo O. Cunningham, MD, MS, and Joanna L. Starrels, MD, MS Marcus A. Bachhuber, Chinazo O. Cunningham, and Joanna L. Starrels are with Division of General Internal Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY. Sean Hennessy is with Center for Clinical Epidemiology and Biostatistics and Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia. … Continue reading

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Magnesium intake decreases Type 2 diabetes Risk through the Improvement of Insulin Resistance and Inflammation

  Magnesium intake decreases Type 2 diabetes Risk through the Improvement of Insulin Resistance and Inflammation http://tinyurl.com/zjbvklt MEDLINE Abstract Hata A ; Doi Y ; Ninomiya T ; Mukai N ; Hirakawa Y ; Hata J ; Ozawa M ; Uchida K ; Shirota T ; Kitazono T ; Kiyohara Y AIMS: Early studies have shown that magnesium intake decreases the risk of Type 2 diabetes, but the results are still inconsistent. We prospectively examined the association between magnesium intake and incidence of Type 2 diabetes … Continue reading

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Association of arterial stiffness with progression of subclinical brain and cognitive disease.

Association of arterial stiffness with progression of subclinical brain and cognitive disease. http://tinyurl.com/jcqsplz Tsao CW1, Himali JJ2, Beiser AS2, Larson MG2, DeCarli C2, Vasan RS2, Mitchell GF2, Seshadri S2. Author information Abstract OBJECTIVE: We tested whether abnormal arterial stiffness and blood pressure would be associated with progression of brain aging measured by brain MRI and neurocognitive testing. METHODS: Framingham Offspring Cohort participants (n = 1,223, 61 ± 9 years, 56% women) without previous stroke or dementia underwent applanation tonometry, brain MRI, and neurocognitive testing at … Continue reading

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Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later

Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later http://tinyurl.com/zzlgg8k Nicole L. Spartano, PhD, Jayandra J. Himali, PhD, Alexa S. Beiser, PhD, Gregory D. Lewis, MD, Charles DeCarli, MD, Ramachandran S. Vasan, MD and Sudha Seshadri, MD +SHOW AFFILIATIONS | + SHOW FULL DISCLOSURES Correspondence to Dr. Spartano: spartano@bu.edu Published online before print February 10, 2016doi:http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000002415Neurology 10.1212/WNL.0000000000002415 ABSTRACT Objective: To determine whether poor cardiovascular (CV) fitness and exaggerated exercise blood pressure (BP) and heart rate (HR) were associated with worse brain morphology in later life. Methods: … Continue reading

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Association of Proton Pump Inhibitors With Risk of Dementia

Association of Proton Pump Inhibitors With Risk of Dementia A Pharmacoepidemiological Claims Data Analysis http://tinyurl.com/zx9n3o8 Willy Gomm, PhD1; Klaus von Holt, MD, PhD1; Friederike Thomé, MSc1; Karl Broich, MD2; Wolfgang Maier, MD1,3; Anne Fink, MSc1,4; Gabriele Doblhammer, PhD1,4,5,6; Britta Haenisch, PhD1   [+] Author Affiliations   JAMA Neurol. Published online February 15, 2016. doi:10.1001/jamaneurol.2015.4791 ABSTRACT Importance  Medications that influence the risk of dementia in the elderly can be relevant for dementia prevention. Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases but have also been shown to be potentially involved in cognitive decline. Objective  To examine the … Continue reading

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The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis

The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis http://tinyurl.com/jur423x Anick Bérard1,2,*, Noha Iessa1,2, Sonia Chaabane1,2, Flory T. Muanda1,2, Takoua Boukhris1,2 and Jin-Ping Zhao1,2 Article first published online: 26 JAN 2016 DOI: 10.1111/bcp.12849 Abstract Aims The aim of this study was to perform an up-to-date meta-analysis on the risk of cardiac malformations associated with gestational exposure to paroxetine, taking into account indication, study design and reference category. Method A systematic review of studies published between 1966 and November 2015 … Continue reading

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Antidepressant Use Is Associated With an Increased Risk of Developing Microbleeds

Antidepressant Use Is Associated With an Increased Risk of Developing Microbleeds http://tinyurl.com/z96cjhk Saloua Akoudad, MD, PhD*; Nikkie Aarts, MSc*; Raymond Noordam, PhD; M. Arfan Ikram, MD, PhD; Henning Tiemeier, MD, PhD; Albert Hofman, MD, PhD; Bruno H. Stricker, MMed, PhD; Meike W. Vernooij, MD, PhD; Loes E. Visser, PharmD, PhD +Author Affiliations From the Departments of Epidemiology (S.A., N.A., R.N., M.A.I., H.T., A.H., B.H.S., M.W.V., L.E.V.), Radiology (S.A., M. A.I., M.W.V.), Neurology (S.A., M.A.I.), Internal Medicine (N.A., R.N., B.H.S., L.E.V.), Psychiatry (H.T.), and Department of Child and Adolescent Psychiatry (H.T.), Erasmus MC–University Medical … Continue reading

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Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports

Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports http://tinyurl.com/hmgdrmx Tarang Sharma, PhD student1 2, Louise Schow Guski, medical student1 2, Nanna Freund, medical student1 2, Peter C Gøtzsche, professor1 2 Author affiliations Correspondence to: T Sharma Nordic Cochrane Centre, Rigshospitalet, Blegdamsvej 9, Department 7811, 2100 Ø Copenhagen, Denmark ts@cochrane.dk Accepted 3 December 2015 Abstract Objective To study serious harms associated with selective serotonin and serotonin-norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main outcome measures Mortality and suicidality. Secondary outcomes were … Continue reading

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Risk of suicide after a concussion

Risk of suicide after a concussion http://tinyurl.com/ha6vrqw Michael Fralick, Deva Thiruchelvam, Homer C. Tien, Donald A. Redelmeier +Author Affiliations Department of Medicine (Fralick, Redelmeier), University of Toronto, Toronto, Ont.; Evaluative Clinical Sciences (Fralick, Thiruchelvam, Tien, Redelmeier), Sunnybrook Research Institute, Toronto, Ont.; Institute for Clinical Evaluative Sciences (Thiruchelvam), Toronto, Ont.; Canadian Forces Health Services (Tien), Toronto, Ont.   Donald A. Redelmeier, E-mail dar@ices.on.ca Abstract Background: Head injuries have been associated with subsequent suicide among military personnel, but outcomes after a concussion in the community are uncertain. We assessed the … Continue reading

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