Category Archives: Affective Neuroscience

Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions

Important paper on childhood adversities an adult-age chronic medical conditions, published just before our study on endogenous opioid dysregulation after early childhood adversity in psychiatrically and physically “healthy” adults.   Archives of General Psychiatry August 2011, Vol 68, No. 8 > < Previous ArticleNext Article > Original Article | Aug 2011 Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions Kate M. Scott, PhD; Michael Von Korff, ScD; Matthias C. Angermeyer, MD, PhD; Corina Benjet, PhD; Ronny Bruffaerts, PhD; Giovanni de Girolamo, MD; Josep Maria Haro, MD, MPH, … Continue reading

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N. Szajnberg, MD on “Lifelong opioidergic vulnerability through early life separation”

Bowlby was a careful observer. His entire volume on Loss spoke to the power of early childhood adversity and later life. More recently, a pediatric nephrologist at Kaiser in collaboration with others has shown that early childhood adversities, including loss, results in later adulthood medical ailments (Filetti et al); and Szajnberg and Massie followed Brodie’s cohort at thirty years to demonstrate this clinically.

Yet, Preter and Klein, citing the work of others, have shown pharmacological evidence of what appears to be a lifelong disorder in opiodergic systems due to childhood loss. Continue reading

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Coronary Heart Disease: Psychological Aspects

Psychological Aspects of Coronary Heart Disease: 126 Studies Published in 2012-2014 Another useful resource provided by the page of Kenneth S. Pope, Ph.D. ABPP, including gems like: Vlachaki, C. and K. Maridaki Kassotaki (2013). “Coronary heart disease and emotional intelligence.” Glob J Health Sci 5(6): 156-165.

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Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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Parental olfactory experience influences behavior and neural structure in subsequent generations : Nature Neuroscience

Nature Neuroscience  Parental olfactory experience influences behavior and neural structure in subsequent generations Brian G Dias & Kerry J Ressler Affiliations Contributions Corresponding authors Nature Neuroscience (2013) doi:10.1038/nn.3594 Received 21 September 2013 Accepted 01 November 2013 Published online 01 December 2013 Article tools Citation Reprints Rights & permissions Article metrics Abstract Abstract• References• Author information• Supplementary information Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor … Continue reading

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DSM-5 focuses on drugs, not talk therapy

DSM-5 focuses on drugs, not talk therapy A well-written and thoughtful op-ed in the Philadelphia Inquirer by a social worker and psychotherapist. Please also re-read my post on expanding illness definitions.

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Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds

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Invitation to my Grand Rounds Talk at Mount Sinai, Wednesday, October 9, 2013, 8am

Please join us for our next Neurology Grand Rounds on Wednesday, October 9th at 8 AM in Davis Auditorium (Hess Center for Science and Medicine) at 1470 Madison Ave between 101st and 102nd streets. Refreshments will be served at 7:30 AM so please feel free to arrive early.

Title: “Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology?”

Presenter: Dr. Maurice Preter, MD
Assistant Professor of Clinical Psychiatry,
Columbia’s College of Physicians and Surgeons;
Associate Professor of Neurology (Adj.),
SUNY Downstate Medical Center, Brooklyn, NY
Continue reading

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Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American

Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American. Highly recommended reading. As it turns out, one does not have to go all the way down the evolutionary ladder to be reminded that even brain-impaired or brain-damaged individuals (whether through TBI, dementia, various levels of unconsciousness, or simply sleep) have not only memories, but continue to experience emotions, good and bad. As an illustration that the brain is made of many different levels and parts, here is a recent paper by Feinstein et … Continue reading

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Concussion epidemic linked to underreported US military suicide – study

New research suggests a link between concussions and suicide in the US military, two frighteningly common issues that the Armed Forces have struggled to explain and curtail since rates started soaring 12 years ago. Earlier this year the military released data showing that active duty service members are taking their own lives more frequently than ever before. There were 349 suicides among active duty military personnel in 2012, averaging just fewer than one per day. There are now more suicides than combat deaths. This was … Continue reading

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Adults with depression and who take specific anti-depressants more likely to develop C. difficile

Interesting applied psychoimmunology study. Apparently depressed people’s guts don’t watch direct-to-consumer chemical-imbalance ads. Here is the abstract. Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers1*, M Todd Greene1, Vincent B Young1, Sanjay Saint1,2, Kenneth M Langa1,2, John Y Kao1 and David M Aronoff1 * Corresponding author: Mary A M Rogers maryroge@umich.edu Author Affiliations For all author emails, please log on.   BMC Medicine 2013, 11:121 doi:10.1186/1741-7015-11-121 Published: 7 May 2013   Abstract Background An ancillary finding in previous research has suggested … Continue reading

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Panic Developments – An Interesting Editorial by Donald F. Klein in the Revista Brasileira de Psiquiatria

Revista Brasileira de Psiquiatria 2012;34(Supl1):S01-S04 Panic Developments This editorial permits personal conclusions and questions, hoping to stimulate relevant research. Klein, in 1959, serendipitously found that imipramine blocked the apparently spontaneous panic attack in non-depressed inpatients, later considered agoraphobic.Later it was found that these specific anti-panic drugs blocked lactate challenges, although low potency benzodiazepines and beta-blockers did not. Also, panic patients with early onset, frequently had a history of severe separation anxiety disorder, often manifested as school phobia. A series of usually post-pubertal panics led to … Continue reading

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