Category Archives: development

Quetiapine safety in older adults?

Quetiapine safety in older adults? Journal of Clinical Pharmacy and Therapeutics Volume 41,  Issue 1, pages 7–18, February 2016 http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12357/abstract Abstract WHAT IS KNOWN AND OBJECTIVE: Quetiapine is a second-generation antipsychotic that is commonly prescribed for a range of approved and off-label indications in older adults. However, little is known about its safety in this population. The available evidence on quetiapine safety is based on studies on second-generation antipsychotics as a group, often in the general population and for approved indications. There are no systematicreviews on the safety … Continue reading

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Bread, pasta and a sedentary lifestyle – will they require disclaimers? Diabetologia: Prediabetes is associated with an increased risk of cancer.

Data from 891,426 participants were derived from 16 prospective cohort studies. Prediabetes was associated with an increased risk of cancer overall (RR 1.15; 95% CI 1.06, 1.23). Continue reading

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Neurology.org: Vitamin D and the risk of dementia and Alzheimer disease

Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions. Continue reading

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N. Szajnberg, MD on “Lifelong opioidergic vulnerability through early life separation”

Bowlby was a careful observer. His entire volume on Loss spoke to the power of early childhood adversity and later life. More recently, a pediatric nephrologist at Kaiser in collaboration with others has shown that early childhood adversities, including loss, results in later adulthood medical ailments (Filetti et al); and Szajnberg and Massie followed Brodie’s cohort at thirty years to demonstrate this clinically.

Yet, Preter and Klein, citing the work of others, have shown pharmacological evidence of what appears to be a lifelong disorder in opiodergic systems due to childhood loss. Continue reading

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Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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The Selling of Attention Deficit Disorder – NYTimes.com

Surprisingly critical, thoroughly researched piece by Alan Schwarz. See also recent posts here (on opening the gigantic Asian market to Western psychotropics), here (on Allen Roses critique of drug efficacy), here (on the DSM V’s focus on, well, drug treatment), here on Allen Frances’ DSM V cost predictions, here (on other types of Western toxic waste profitably deposited in the anything-goes Chinese market), my own alternative views on medical-psychiatric diagnosis and care here and here. Health Log In Register Now Help The Selling of Attention … Continue reading

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Parental olfactory experience influences behavior and neural structure in subsequent generations : Nature Neuroscience

Nature Neuroscience  Parental olfactory experience influences behavior and neural structure in subsequent generations Brian G Dias & Kerry J Ressler Affiliations Contributions Corresponding authors Nature Neuroscience (2013) doi:10.1038/nn.3594 Received 21 September 2013 Accepted 01 November 2013 Published online 01 December 2013 Article tools Citation Reprints Rights & permissions Article metrics Abstract Abstract• References• Author information• Supplementary information Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor … Continue reading

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Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American

Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American. Highly recommended reading. As it turns out, one does not have to go all the way down the evolutionary ladder to be reminded that even brain-impaired or brain-damaged individuals (whether through TBI, dementia, various levels of unconsciousness, or simply sleep) have not only memories, but continue to experience emotions, good and bad. As an illustration that the brain is made of many different levels and parts, here is a recent paper by Feinstein et … Continue reading

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Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.

Phytother Res. 2013 Jul 6. doi: 10.1002/ptr.5025. [Epub ahead of print] Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial. Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Source Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India. Abstract Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential antidepressant-like activity in animal studies. The objectives of this trial were to compare the efficacy and safety of curcumin with fluoxetine in … Continue reading

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Calorie restriction: what recent results suggest for the future of ageing research.

Eur J Clin Invest. 2010 May;40(5):440-50. doi: 10.1111/j.1365-2362.2010.02276.x. Calorie restriction: what recent results suggest for the future of ageing research. Smith DL Jr, Nagy TR, Allison DB. Source Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA. dsmithjr@uab.edu Abstract BACKGROUND: Calorie Restriction (CR) research has expanded rapidly over the past few decades and CR remains the most highly reproducible, environmental intervention to improve health and extend lifespan in animal studies. Although many model organisms have consistently demonstrated positive responses to CR, … Continue reading

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Two adult case reports of improved neurological status with the removal of gluten from diet

Two adult case reports of improved neurological status with the removal of gluten from diet Author: Sue Wood Co-author Beth Zupec-Kania 1.Dietitian, Matthews Friends Clinics 2.Nutrition Consultant Key words: 1. Gluten-free 2. Gluten sensitivity 3. Epilepsy 4. Neurological dysfunction Introduction: Gluten sensitivity is a systemic autoimmune or immune mediated disease with diverse manifestations 1. Coeliac disease (CD) is the most commonly recognized of these and estimated to occur in at least 1% of the population. There has been conflicting data provided by studies of the … Continue reading

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The effect and Long-term retention rate of ketogenic diet in Chinese patients.

The effect and Long-term retention rate of ketogenic diet in Chinese patients Author: DENG Yu Hong Co-authors ZHOU Jin-Hua, LI Bing-Mei, LIU Xiao-Rong, LIAO Wei-Ping Changgang Dong road 250, haiZhu, Guangzhou, GuangDong, P.R China,510260 Keyword 1 ketogenic diet Keyword 2 refractory epilepsy Keyword 3 effect Keyword 4 retention rate Objective: To evaluate the effect and long-term retention of ketogenic diet (KD) in add-on therapy for refractory epilepsy patients with Chinese eating habits. Methods: 28 Chinese patients with refractory epilepsy were recruited in one and half … Continue reading

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