Category Archives: epigenetics

Panic Attacks and Panic Disorder – what is it and how can it be treated?

Panic Attacks and Panic Disorder – what is it and how can it be treated? Continue reading

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Alzheimer’s Disease – what is it and how can it be treated?

Alzheimer’s Disease – what is it and how can it be treated? Continue reading

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Dementia and Alzheimers’ Disease – How Can It Be Treated?

Dementia and Alzheimers’ Disease – How Can It Be Treated?

The Latin word “De-mentia”, literally means, the removal of a person from their own mind. It stands for a significant decrease in brain function, including memory, goal-directed thinking, orientation in space and time, and language ability.

Most dementias are progressive. They cannot be cured and will gradually cause more severe problems for the patient, and for the patient’s caretakers. As the population ages, Alzheimer’s disease is on its way to becoming the third most common fatal disease.

Prescription medications on the market starting in the 1990s to treat dementia have been a disappointment to patients and doctors alike.

The frustration caused by this situation prompted me to make the development of an anti-dementia treatment protocol a major focus of my clinical work.

As always, we start with a thorough neuropsychiatric assessment, looking for potentially reversible causes of cognitive decline such as a thyroid condition, vitamin deficiency, a sleep disorder, elevated blood sugar and diabetes. Importantly, untreated depression and chronic high stress and anxiety levels are associated with a higher risk for dementia. Most of the time, psychotherapy is a far better alternative to the all-too-common multiple prescription drugs.

The protocol uses a number of carefully evaluated novel interventions and components based on sound neuroscientific principles, sourced from both functional medicine and traditional medical systems, such as Ayurvedic and traditional Chinese medicine.

The protocol stabilizes many of my patients, and improves their functioning and quality of life. It has shown promising results not only for dementia, but also for traumatic brain injury. Continue reading

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Living near major traffic linked to higher risk of dementia

Living near major traffic linked to higher risk of dementia This type of air pollution is now emerging as a major risk factor. Possibly related to brain deposits of magnetite microspheres? People who live close to high-traffic roadways face a higher risk of developing dementia than those who live further away, new research from Public Health Ontario (PHO) and the Institute for Clinical Evaluative Sciences (ICES) has found. Led by PHO and ICES scientists, the study found that people who lived within 50 metres of high-traffic roads … Continue reading

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Relationships Between Caffeine Intake and Risk for Probable Dementia or Global Cognitive Impairment: The Women’s Health Initiative Memory Study

Relationships Between Caffeine Intake and Risk for Probable Dementia or Global Cognitive Impairment: The Women’s Health Initiative Memory Study   Ira Driscoll1, Sally A. Shumaker2, Beverly M. Snively3, Karen L. Margolis4, JoAnn E. Manson5, Mara Z. Vitolins6, Rebecca C. Rossom4 and Mark A. Espeland3 +Author Affiliations 1 Department of Psychology, University of Wisconsin–Milwaukee. 2 Department of Social Sciences and Health Policy and 3 Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina. 4 Health Partners Institute for Education and Research, Minneapolis, Minnesota. 5 Department of Medicine, … Continue reading

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Arthritis and suicide attempts: findings from a large nationally representative Canadian survey

Arthritis and suicide attempts: findings from a large nationally representative Canadian survey The objectives of this study were (1) to determine the odds of suicide attempts among those with arthritis compared with those without and to see what factors attenuate this association and (2) to identify which factors are associated with suicide attempts among adults with arthritis. Secondary data analysis of the nationally representative 2012 Canadian Community Health Survey-Mental Health (CCHS-MH) was performed. For objective 1, those with and without arthritis were included (n = 21,744). For … Continue reading

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Just Published: Panic Disorder: Neurobiological and Treatment Aspects 1st ed. 2016 Edition

I am very pleased that this interesting collaborative project has come to fruition. Great introductory chapter by Nardi and Freire, numerous excellent contributions, and a recap of our panic theory and data showing that early childhood loss causes permanent changes in the endogenous opioid system of asymptomatic, clinically healthy adults. Continue reading

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Periodontitis and Cognitive Decline in Alzheimer’s Disease

Periodontitis and Cognitive Decline in Alzheimer’s Disease Continue reading

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Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition.

  Richard Carlton MD asked me to post abstracts related to the well-established but under-appreciated dopamine-blocking effect of metoclopramide. Ned Tijdschr Geneeskd. 2013;157(26):A6037. Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition. [Article in Dutch] de Ronde MW1, Kingma HJ, Munts AG. Author information 1Kennemer Gasthuis, afd. Neurologie, Haarlem, the Netherlands. mwjderonde@gmail.com Abstract In this article, we present 3 women aged 73, 85 and 88 years who developed metoclopramide-induced parkinsonism. Shortly after starting metoclopramide, bradykinesia and rigidity developed in all 3 patients; tremor and postural instability … Continue reading

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A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-28 Ingrid Van der Auwera, Stefaan Wera, Fred Van Leuven and Samuel T HendersonEmail author Nutrition & Metabolism20052:28 DOI: 10.1186/1743-7075-2-28 ©  Van der Auwera et al; licensee BioMed Central Ltd. 2005 Received: 09 August 2005 Accepted: 17 October 2005 Published: 17 October 2005 Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and development of AD. Yet, these studies did … Continue reading

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Neuroprotective and disease-modifying effects of the ketogenic diet

Neuroprotective and disease-modifying effects of the ketogenic diet Behav Pharmacol. Author manuscript; available in PMC 2008 May 5. Published in final edited form as: Behav Pharmacol. 2006 Sep; 17(5-6): 431–439. Reading it again.. Well worth it. Abstract The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer long-lasting therapeutic benefits for patients with epilepsy. Moreover, there is evidence from uncontrolled … Continue reading

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Risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy

The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: A systematic review and meta-analysis   http://onlinelibrary.wiley.com/doi/10.1111/bcp.12849/abstract Anick Bérard1,2,*, Noha Iessa1,2, Sonia Chaabane1,2, Flory T. Muanda1,2, Takoua Boukhris1,2 and Jin-Ping Zhao1,2 DOI: 10.1111/bcp.12849 This article is protected by copyright. All rights reserved. Issue British Journal of Clinical Pharmacology Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) Additional Information(Show All) Author InformationPublication History This article has been accepted for … Continue reading

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