Category Archives: metabolic

Bread, pasta and a sedentary lifestyle – will they require disclaimers? Diabetologia: Prediabetes is associated with an increased risk of cancer.

Data from 891,426 participants were derived from 16 prospective cohort studies. Prediabetes was associated with an increased risk of cancer overall (RR 1.15; 95% CI 1.06, 1.23). Continue reading

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Salt intake is associated with inflammation in chronic heart failure.

Int Cardiovasc Res J. 2014 Sep;8(3):89-93. Epub 2014 Sep 1. Salt intake is associated with inflammation in chronic heart failure. Azak A1, Huddam B1, Gonen N2, Yilmaz SR3, Kocak G1, Duranay M1. Author information Abstract BACKGROUND: Chronic Heart Failure (CHF) is highly prevalent and is associated with high morbidity and mortality rates. It has been well established that excessive intake of sodium chloride (salt) induced hypertension in some populations. Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from … Continue reading

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Neurology.org: Vitamin D and the risk of dementia and Alzheimer disease

Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions. Continue reading

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Simvastatin impairs exercise training adaptations.

Simvastatin impairs exercise training adaptations. Mikus CR, et al. Show all J Am Coll Cardiol. 2013 Aug 20;62(8):709-14. doi: 10.1016/j.jacc.2013.02.074. Epub 2013 Apr 10. Affiliation Division of Cardiology, Duke University Medical Center, Durham, North Carolina. Abstract OBJECTIVES: This study sought to determine if simvastatin impairs exercise training adaptations. BACKGROUND: Statins are commonly prescribed in combination with therapeutic lifestyle changes, including exercise, to reduce cardiovascular disease risk in patients with metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired mitochondrial function, but … Continue reading

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Among well-functioning older adults, DM and poor glucose control among those with DM are associated with worse cognitive function and greater decline. This suggests that severity of DM may contribute to accelerated cognitive aging.

Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. Yaffe K, et al. Show all Arch Neurol. 2012 Sep;69(9):1170-5. doi: 10.1001/archneurol.2012.1117. Affiliation Departments of Psychiatry, University of California, San Francisco, and San Francisco, VA, USA. kristine.yaffe@ucsf.edu Abstract OBJECTIVES: To determine if prevalent and incident diabetes mellitus (DM) increase risk of cognitive decline and if, among elderly adults with DM, poor glucose control is related to worse cognitive performance. DESIGN Prospective cohort study. SETTING: Health, Aging, and Body Composition Study at 2 community … Continue reading

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Calorie restriction: what recent results suggest for the future of ageing research.

Eur J Clin Invest. 2010 May;40(5):440-50. doi: 10.1111/j.1365-2362.2010.02276.x. Calorie restriction: what recent results suggest for the future of ageing research. Smith DL Jr, Nagy TR, Allison DB. Source Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA. dsmithjr@uab.edu Abstract BACKGROUND: Calorie Restriction (CR) research has expanded rapidly over the past few decades and CR remains the most highly reproducible, environmental intervention to improve health and extend lifespan in animal studies. Although many model organisms have consistently demonstrated positive responses to CR, … Continue reading

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The promise of dietary restriction mimetics in healthy aging

Biofactors. 2010 Sep-Oct;36(5):377-82. doi: 10.1002/biof.127. Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging. Mouchiroud L, Molin L, Dallière N, Solari F. Source UMR, CNRS Université Lyon, Centre Léon Bérard, France. Abstract Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our … Continue reading

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More on Vitamin D deficiency in Hashimoto’s thyroiditis

The need for high dose steroid treatment or even IVIG seems to be called into question based on these results. One ounce of prevention? 1.    J Pediatr Endocrinol Metab. 2012;25(5-6):467-70. Vitamin D status in children with Hashimoto thyroiditis. Camurdan OM, Döğer E, Bideci A, Celik N, Cinaz P. Department of Pediatric Endocrinology, School of Medicine, Gazi University, Ankara, Turkey. turkalpo@yahoo.com Abstract OBJECTIVE: To investigate vitamin D status in children with Hashimoto thyroiditis. SUBJECTS AND METHODS: The study group consisted of 78 children recently diagnosed as … Continue reading

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Neuroprotective properties of magnesium infusion during carotid endarterectomy, and beyond?

Went to a masterful talk by E. Sander Connolly at the Lenox Hill Hospital neurology conference last week. This is one of many interesting take-away points. Differential blood-brain barrier penetration by the various statins is another one – currently looking into how this impacts clinical decision making. MP J Neurosurg. Author manuscript; available in PMC 2009 July 1. Published in final edited form as: J Neurosurg. 2009 May; 110(5): 961–967. doi:  10.3171/2008.9.17671 PMCID: PMC2684565 NIHMSID: NIHMS101036 Intraoperative magnesium infusion during carotid endarterectomy: a double-blind placebo-controlled … Continue reading

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The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy.

Front Neurosci. 2012;6:33. doi: 10.3389/fnins.2012.00033. Epub 2012 Mar 26. The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy. Ruskin DN, Masino SA. Source Neuroscience Program, Department of Psychology, Trinity College Hartford, CT, USA. Abstract A link between metabolism and brain function is clear. Since ancient times, epileptic seizures were noted as treatable with fasting, and historical observations of the therapeutic benefits of fasting on epilepsy were confirmed nearly 100 years ago. Shortly thereafter a high fat, low-carbohydrate ketogenic diet (KD) debuted as … Continue reading

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Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.

PLoS One. 2009 Dec 23;4(12):e8349. doi: 10.1371/journal.pone.0008349. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. Ruskin DN, Kawamura M, Masino SA. Source Department of Psychology and Neuroscience Program, Trinity College, Hartford, Connecticut, United States of America. Abstract The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes, and recent basic research provides evidence that ketogenic strategies … Continue reading

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Vitamin D deficiency treated by consuming UVB-irradiated mushrooms

Vitamin D deficiency treated by consuming UVB-irradiated mushrooms. Vitamin D deficiency treated by consuming UVB-irradiated mushrooms Andrew Ozzard, DCH, MRCPCH, GP Registrar and Gurdip Hear, BSc, DCH, DRCOG, DFFP, MRCGP, GP Trainer Crosby House Surgery, Slough Gavin Morrison, MBBS, FY1 Leighton Hospital, Crewe, Cheshire Mike Hoskin, DRCOG, MRCGP, GP Trainer Author information ► Article notes ► Copyright and License information ► Abstract Deficiency of vitamin D is usually caused by dietary deficiency and/or lack of exposure to sunlight in dark skinned individuals living at northern … Continue reading

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