Category Archives: new treatments

Metabolic features of the cell danger response. [Mitochondrion. 2013] – PubMed – NCBI

This is a really exciting integrative paper on the (clinically and heuristically relevant) hot topic du jour: Inflammation.  I came across it when I was researching Tourette’s syndrome and inflammation – am seeing increasing numbers of patients without a good explanation for their symptom exacerbation, with respiratory disease and low Vitamin D levels. Mitochondrion. 2013 Aug 24. pii: S1567-7249(13)00239-0. doi: 10.1016/j.mito.2013.08.006. [Epub ahead of print] Metabolic features of the cell danger response. Naviaux RK. Author information Abstract The cell danger response (CDR) is the evolutionarily … Continue reading

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Why hospitals will soon sequence the genes of every single patient | VentureBeat | Big Data | by Romain Nervil

Why hospitals will soon sequence the genes of every single patient Great, timely post courtesy of VentureBeat.com   via Why hospitals will soon sequence the genes of every single patient | VentureBeat | Big Data | by Romain Nervil.

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Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.

Phytother Res. 2013 Jul 6. doi: 10.1002/ptr.5025. [Epub ahead of print] Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial. Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Source Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India. Abstract Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential antidepressant-like activity in animal studies. The objectives of this trial were to compare the efficacy and safety of curcumin with fluoxetine in … Continue reading

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Calorie restriction: what recent results suggest for the future of ageing research.

Eur J Clin Invest. 2010 May;40(5):440-50. doi: 10.1111/j.1365-2362.2010.02276.x. Calorie restriction: what recent results suggest for the future of ageing research. Smith DL Jr, Nagy TR, Allison DB. Source Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA. dsmithjr@uab.edu Abstract BACKGROUND: Calorie Restriction (CR) research has expanded rapidly over the past few decades and CR remains the most highly reproducible, environmental intervention to improve health and extend lifespan in animal studies. Although many model organisms have consistently demonstrated positive responses to CR, … Continue reading

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The promise of dietary restriction mimetics in healthy aging

Biofactors. 2010 Sep-Oct;36(5):377-82. doi: 10.1002/biof.127. Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging. Mouchiroud L, Molin L, Dallière N, Solari F. Source UMR, CNRS Université Lyon, Centre Léon Bérard, France. Abstract Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our … Continue reading

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Vitamin D and risk of death from vascular and no… [Eur Heart J. 2013] – PubMed – NCBI

Eur Heart J. 2013 May;34(18):1365-74. doi: 10.1093/eurheartj/ehs426. Epub 2012 Dec 20. Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12,000 deaths. Tomson J, Emberson J, Hill M, Gordon A, Armitage J, Shipley M, Collins R, Clarke R. Source Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK. Abstract AIMS: To examine the independent relevance of plasma concentrations of 25-hydroxyvitamin D [25(OH)D] … Continue reading

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Neuroprotective properties of magnesium infusion during carotid endarterectomy, and beyond?

Went to a masterful talk by E. Sander Connolly at the Lenox Hill Hospital neurology conference last week. This is one of many interesting take-away points. Differential blood-brain barrier penetration by the various statins is another one – currently looking into how this impacts clinical decision making. MP J Neurosurg. Author manuscript; available in PMC 2009 July 1. Published in final edited form as: J Neurosurg. 2009 May; 110(5): 961–967. doi:  10.3171/2008.9.17671 PMCID: PMC2684565 NIHMSID: NIHMS101036 Intraoperative magnesium infusion during carotid endarterectomy: a double-blind placebo-controlled … Continue reading

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The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy.

Front Neurosci. 2012;6:33. doi: 10.3389/fnins.2012.00033. Epub 2012 Mar 26. The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy. Ruskin DN, Masino SA. Source Neuroscience Program, Department of Psychology, Trinity College Hartford, CT, USA. Abstract A link between metabolism and brain function is clear. Since ancient times, epileptic seizures were noted as treatable with fasting, and historical observations of the therapeutic benefits of fasting on epilepsy were confirmed nearly 100 years ago. Shortly thereafter a high fat, low-carbohydrate ketogenic diet (KD) debuted as … Continue reading

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Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.

PLoS One. 2009 Dec 23;4(12):e8349. doi: 10.1371/journal.pone.0008349. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. Ruskin DN, Kawamura M, Masino SA. Source Department of Psychology and Neuroscience Program, Trinity College, Hartford, Connecticut, United States of America. Abstract The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes, and recent basic research provides evidence that ketogenic strategies … Continue reading

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Fingolimod treatment for multiple sclerosis patients What do we do with varicella?

Fingolimod treatment for multiple sclerosis patie… [Ann Neurol. 2011] – PubMed – NCBI. Ann Neurol. 2011 Oct;70(4):673-4; author reply 674. doi: 10.1002/ana.22605. Fingolimod treatment for multiple sclerosis patients What do we do with varicella? Winkelmann A, Loebermann M, Reisinger EC, Hartung HP, Zettl UK. Comment on Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis. [Ann Neurol. 2011] PMID: 22028236 [PubMed – indexed for MEDLINE] Publication Types, MeSH Terms, Substances LinkOut – more resources

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Melanoma occurring during treatment with fingo… [Arch Dermatol. 2011] – PubMed – NCBI

Arch Dermatol. 2011 Aug;147(8):991-2. doi: 10.1001/archdermatol.2011.212. Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. Conzett KB, Kolm I, Jelcic I, Kamarachev J, Dummer R, Braun R, French LE, Linnebank M, Hofbauer GF. PMID: 21844470 [PubMed – indexed for MEDLINE] Publication Types, MeSH Terms, Substances LinkOut – more resources via Melanoma occurring during treatment with fingo… [Arch Dermatol. 2011] – PubMed – NCBI.

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Delayed fingolimod-associated asystole. [Mult Scler. 2011] – PubMed – NCBI

Mult Scler. 2011 Nov;17(11):1387-9. doi: 10.1177/1352458511410344. Epub 2011 Jun 7. Delayed fingolimod-associated asystole. Espinosa PS, Berger JR. Source North Oaks Neurology, Hammond, LA, USA. ps.espinosa@gmail.com Abstract Oral fingolimod (Gilenya) is a sphingosine-1-phosphate-receptor modulator that prevents the egress of lymphocytes from lymph nodes. Fingolimod reduces relapses and delays disability progression in patients with relapsing forms of multiple sclerosis (MS). We report a patient with MS who developed asystole and sustained bradycardia 21 hours after the first dose of fingolimod. PMID: 21652609 [PubMed – indexed for MEDLINE] … Continue reading

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