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This is a really exciting integrative paper on the (clinically and heuristically relevant) hot topic du jour: Inflammation. I came across it when I was researching Tourette’s syndrome and inflammation – am seeing increasing numbers of patients without a good explanation for their symptom exacerbation, with respiratory disease and low Vitamin D levels. Mitochondrion. 2013 Aug 24. pii: S1567-7249(13)00239-0. doi: 10.1016/j.mito.2013.08.006. [Epub ahead of print] Metabolic features of the cell danger response. Naviaux RK. Author information Abstract The cell danger response (CDR) is the evolutionarily … Continue reading
A senior executive with Britain’s biggest drugs company has admitted that most prescription medicines do not work on most people who take them. Science – News – The Independent
I just had the great pleasure of meeting Allen Roses. The 2003 article quoted is a reminder of “plus ca change, plus c’est la meme chose”. Glaxo chief: Our drugs do not work on most patients – Science – News – The Independent.
DSM-5 focuses on drugs, not talk therapy A well-written and thoughtful op-ed in the Philadelphia Inquirer by a social worker and psychotherapist. Please also re-read my post on expanding illness definitions.
Please join us for our next Neurology Grand Rounds on Wednesday, October 9th at 8 AM in Davis Auditorium (Hess Center for Science and Medicine) at 1470 Madison Ave between 101st and 102nd streets. Refreshments will be served at 7:30 AM so please feel free to arrive early.
Title: “Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology?”
Presenter: Dr. Maurice Preter, MD
Assistant Professor of Clinical Psychiatry,
Columbia’s College of Physicians and Surgeons;
Associate Professor of Neurology (Adj.),
SUNY Downstate Medical Center, Brooklyn, NY
Could not resist posting this ad I found in a local NYC Japanese magazine.
I came across this interesting article Colizoli O, Murre JM, and Rouw R (2012). Pseudo-Synesthesia through Reading Books with Colored Letters. PloS one, 7 (6) PMID: 22761905 posted at http://neuroskeptic.blogspot.com/2012/07/can-you-learn-to-be-synaesthetic.html I agree with the blogger and some real syn-esthetics who commented that it really has little to do with synesthesia, and more with mnemotechnic. I wonder if it could be used to learn Chinese characters.
Pro- and anti-inflammatory cytokines expression in rat’s brain and spleen exposed to chronic mild stress: involvement in depression.
Behav Brain Res. 2011 Nov 20;225(1):135-41. Epub 2011 Jul 8.Pro- and anti-inflammatory cytokines expression in rat’s brain and spleen exposed to chronic mild stress: involvement in depression.You Z, Luo C, Zhang W, Chen Y, He J, Zhao Q, Zuo R, Wu Y.Source Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China. email@example.comAbstract The association between pro-inflammatory cytokines and depression has been reported by many studies. However, the mechanisms by … Continue reading
Sleep Breath. 2009 Mar;13(1):35-41. Epub 2008 Jun 13.Relationship between inflammation and cognitive function in obstructive sleep apnea.Haensel A, Bardwell WA, Mills PJ, Loredo JS, Ancoli-Israel S, Morgan EE, Heaton RK, Dimsdale JE.Source Department of General Internal Medicine, University Hospital Berne, Berne, Switzerland.AbstractOBJECTIVES: Obstructive sleep apnea (OSA) can have adverse effects on cognitive functioning, mood, and cardiovascular functioning. OSA brings with it disturbances in sleep architecture, oxygenation, sympathetic nervous system function, and inflammatory processes. It is not clear which of these mechanisms is linked to the … Continue reading
Reductionistic but still of interest. Psychol Bull. 2007 Nov;133(6):1007-37.Substance P at the nexus of mind and body in chronic inflammation and affective disorders.Rosenkranz MA.Source Department of Psychology, University of Wisconsin-Madison, WI 53705, USA. firstname.lastname@example.orgAbstract For decades, research has demonstrated that chronic diseases characterized by dysregulation of inflammation are particularly susceptible to exacerbation by stress and emotion. Likewise, rates of depression and anxiety are overrepresented in individuals suffering from chronic inflammatory disease. In recent years, substance P has been implicated in both the pathophysiology of inflammatory … Continue reading
Effects of seasonal mood changes on seasonal variations in coronary heart disease: role of immune system, infection, and inflammation.
Nice piece by Leo Sher from before the Vitamin D connection was on everyone’s mind. Med Hypotheses. 2001 Jan;56(1):104-6.Effects of seasonal mood changes on seasonal variations in coronary heart disease: role of immune system, infection, and inflammation.Sher L.Abstract Coronary heart disease shows a winter peak and summer trough in incidence and mortality. A substantial part of a general population experiences seasonal mood changes including winter depression. Many studies demonstrate that depression is associated with increased incidence, morbidity, and mortality of cardiovascular disease. Therefore, the author … Continue reading
Should I Resign From the American Psychiatric Association? – Psychiatric Times