Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial

Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial Ramón C Hermida, Juan J Crespo, Manuel Domínguez-Sardiña, Alfonso Otero, Ana Moyá, María T Ríos, Elvira Sineiro, María C Castiñeira, Pedro A Callejas, Lorenzo Pousa … Show more Author Notes European Heart Journal, ehz754, https://doi.org/10.1093/eurheartj/ehz754 Published: 22 October 2019 Article history PDF Split View Cite Permissions Icon Permissions Share Abstract Aims The Hygia Chronotherapy Trial, conducted within the clinical primary care setting, was designed to test whether bedtime in comparison to usual upon awakening … Continue reading

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Why 100,000 poop photos may bring the next big thing in fitness tracking New crowdsourcing initiative aims to build an app that tracks users’ gastrointestinal health.

Why 100,000 poop photos may bring the next big thing in fitness tracking New crowdsourcing initiative aims to build an app that tracks users’ gastrointestinal health. https://www.nbcnews.com/mach/amp/ncna1072726

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Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele

Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele List of authors. Peter G. Middleton, M.D., Marcus A. Mall, M.D., Pavel Dřevínek, M.D., Larry C. Lands, M.D., Edward F. McKone, M.D., Deepika Polineni, M.D., Bonnie W. Ramsey, M.D., Jennifer L. Taylor-Cousar, M.D., Elizabeth Tullis, M.D., François Vermeulen, M.D., Gautham Marigowda, M.D., Charlotte M. McKee, M.D., et al. Abstract BACKGROUND Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, and nearly 90% of patients have at least … Continue reading

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High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster

ARTICLE| VOLUME 27, ISSUE 6, P1675-1685.E7, MAY 07, 2019 https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30492-9 High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster Christina E. May Anoumid Vaziri Yong Qi Lin Peter L. Freddolino G. Gregory Neely Monica Dus 9 Show all authors Show footnotes Open AccessDOI:https://doi.org/10.1016/j.celrep.2019.04.027 Highlights • A high sugar diet decreases sweet taste sensation • Blunted sweet taste promotes overconsumption and obesity • Excess dietary sugar impairs taste function … Continue reading

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Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep.

Science. 2019 Nov 1;366(6465):628-631. doi: 10.1126/science.aax5440. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Fultz NE1,2, Bonmassar G2,3, Setsompop K2,3, Stickgold RA4,5, Rosen BR2,3, Polimeni JR2,3, Lewis LD6,2. Author information 1 Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. 2 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA. 3 Department of Radiology, Harvard Medical School, Boston, MA 02115, USA. 4 Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. 5 Department of … Continue reading

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An elegy by Arthur Kleinman

THE LANCET PERSPECTIVES|THE ART OF MEDICINE| VOLUME 394, ISSUE 10199, P630-631, AUGUST 24, 2019 The soul in medicine Arthur Kleinman Beginning of article: “When I was a child in New York City in the 1940s, the word “soul” was commonly invoked in school, in the neighbourhood, at home, and on the radio. Soul had a strong religious connotation, and was invoked regularly in the synagogue I attended as well as in the churches my late wife visited as a young girl. The social gospel orientation … Continue reading

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Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer’s disease

Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer’s disease Potential use of Big Data mined from a VR game for preclinical diagnostics… Source: https://www.pnas.org/content/116/19/9285 Significance We report that assessment of navigational behavior using the Sea Hero Quest app provides a means of discriminating healthy aging from genetically at-risk individuals of Alzheimer’s disease (AD). It further highlights that the global Sea Hero Quest database can be employed as a normative benchmark dataset to efficiently determine the significance of spatial abnormality suspected to be indicative of incipient AD on … Continue reading

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Whole-Body Cryotherapy a Hot New Treatment for Depression?

News > Medscape Medical News > Conference News > EPA 2019 Whole-Body Cryotherapy a Hot New Treatment for Depression? Liam Davenport April 11, 2019 7Read Comments ADD TO EMAIL ALERTS WARSAW, Poland — Adjunctive whole-body cryotherapy may convey added benefit in patients with depressive disorders, new research suggests. This type of therapy, which involves subjecting the body to extremely low temperatures for short periods of time, is already used in rheumatoid and neurologic conditions, as well as for biological rejuvenation in athletes. There is also a small, … Continue reading

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Use of vitamin D drops leading to kidney failure in a 54-year-old man

Vitamin D supplementation plus sunbathing. Use of vitamin D drops leading to kidney failure in a 54-year-old man Bourne L. Auguste, Carmen Avila-Casado and Joanne M. Bargman CMAJ April 08, 2019 191 (14) E390-E394; DOI: https://doi.org/10.1503/cmaj.180465 Article Figures & Tables Related Content Responses Metrics PDF KEY POINTS Vitamin D toxicity is rare, but clinicians must be aware of the risks of vitamin D use to limit complications related to hypercalcemia. Calcium levels may get worse before getting better in patients even after cessation of supplements, … Continue reading

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Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease

Cardiac risk factors and prevention Original research article Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease   Ralph Kwame Akyea, Joe Kai, Nadeem Qureshi, Barbara Iyen, Stephen F Weng Author affiliations Abstract Objective To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of cardiovascular disease (CVD). Methods Prospective cohort study of 165 411 primary care patients, from the UK Clinical Practice Research Datalink, who were free of CVD before statin initiation, and had at … Continue reading

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Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline

Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline Continue reading

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Long-Term Consumption of Sugar- Sweetened and Artificially Sweetened Beverages and Risk of Mortality in US Adults

Long-Term Consumption of Sugar- Sweetened and Artificially Sweetened Beverages and Risk of Mortality in US Adults Continue reading

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