Tag Archives: adverse childhood events

Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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Parental olfactory experience influences behavior and neural structure in subsequent generations : Nature Neuroscience

Nature Neuroscience  Parental olfactory experience influences behavior and neural structure in subsequent generations Brian G Dias & Kerry J Ressler Affiliations Contributions Corresponding authors Nature Neuroscience (2013) doi:10.1038/nn.3594 Received 21 September 2013 Accepted 01 November 2013 Published online 01 December 2013 Article tools Citation Reprints Rights & permissions Article metrics Abstract Abstract• References• Author information• Supplementary information Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor … Continue reading

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Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds

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Invitation to my Grand Rounds Talk at Mount Sinai, Wednesday, October 9, 2013, 8am

Please join us for our next Neurology Grand Rounds on Wednesday, October 9th at 8 AM in Davis Auditorium (Hess Center for Science and Medicine) at 1470 Madison Ave between 101st and 102nd streets. Refreshments will be served at 7:30 AM so please feel free to arrive early.

Title: “Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology?”

Presenter: Dr. Maurice Preter, MD
Assistant Professor of Clinical Psychiatry,
Columbia’s College of Physicians and Surgeons;
Associate Professor of Neurology (Adj.),
SUNY Downstate Medical Center, Brooklyn, NY
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Life event stress and chronic obstructive pulmonary disease (COPD)

BMJ Open. 2012 Nov 19;2(6). pii: e001674. doi: 10.1136/bmjopen-2012-001674. Print 2012. Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study. Lu Y, Nyunt MS, Gwee X, Feng L, Feng L, Kua EH, Kumar R, Ng TP. Source Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Abstract OBJECTIVES: To investigate whether life event stress was associated with greater psychological distress and poorer quality of life in older … Continue reading

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Identification of candidate IgG biomarkers for Alzheimer’s disease via combinatorial library screening.

This is important news. Cell. 2011 Jan 7;144(1):132-42. doi: 10.1016/j.cell.2010.11.054. Identification of candidate IgG biomarkers for Alzheimer’s disease via combinatorial library screening. Reddy MM, Wilson R, Wilson J, Connell S, Gocke A, Hynan L, German D, Kodadek T. Source Opko Health Laboratories, Jupiter, FL 33458, USA. Abstract The adaptive immune system is thought to be a rich source of protein biomarkers, but diagnostically useful antibodies remain unknown for a large number of diseases. This is, in part, because the antigens that trigger an immune response … Continue reading

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Adults with depression and who take specific anti-depressants more likely to develop C. difficile

Interesting applied psychoimmunology study. Apparently depressed people’s guts don’t watch direct-to-consumer chemical-imbalance ads. Here is the abstract. Depression, antidepressant medications, and risk of Clostridium difficile infection Mary A M Rogers1*, M Todd Greene1, Vincent B Young1, Sanjay Saint1,2, Kenneth M Langa1,2, John Y Kao1 and David M Aronoff1 * Corresponding author: Mary A M Rogers maryroge@umich.edu Author Affiliations For all author emails, please log on.   BMC Medicine 2013, 11:121 doi:10.1186/1741-7015-11-121 Published: 7 May 2013   Abstract Background An ancillary finding in previous research has suggested … Continue reading

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Scourge of depression sees rising number of suicides, report Cang Wei and Song Wenwei in Nanjing.

Staggering base rate… Dark days of despair drive many to the final option Updated: 2013-02-27 09:20 By Cang Wei and Song Wenwei in Nanjing/China Daily Scourge of depression sees rising number of suicides, report Cang Wei and Song Wenwei in Nanjing. Every three minutes, a person suffering from depression commits suicide in China and a further 11 people attempt to take their own lives.Every year in China, 287,000 people end their lives by suicide, while another 2 million contemplate the act, 70 percent of them … Continue reading

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Daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1878-82. Epub 2012 Jan 23. Negative and competitive social interactions are related to heightened proinflammatory cytokine activity. Chiang JJ, Eisenberger NI, Seeman TE, Taylor SE. Source Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Abstract Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor … Continue reading

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Social pain–the painful feelings associated with social disconnection–rely on some of the same neurobiological substrates that underlie experiences of physical pain

Nat Rev Neurosci. 2012 May 3;13(6):421-34. doi: 10.1038/nrn3231. The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Eisenberger NI. Source University of California, Department of Psychology, 4444 Franz Hall, Los Angeles, California 90095, USA. neisenbe@ucla.edu Abstract Experiences of social rejection, exclusion or loss are generally considered to be some of the most ‘painful’ experiences that we endure. Indeed, many of us go to great lengths to avoid situations that may engender these experiences (such as public speaking). Why is … Continue reading

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An endogenous opioid deficiency/expanded suffocation false alarm theory model of panic disorder.

These are the slides from my  talk at the First International Symposium on Translational Models of Panic Disorder. Vitoria, ES, Brazil, November 16-18, 2012.

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Neonatal maternal separation disrupts regulation of sl… [Sleep. 2009] – PubMed – NCBI

Listening to fascinating data by Richard Kinkead at http://www.simposiodopanico.com.br/site/?lang=en. Here is a relevant abstract: Sleep. 2009 Dec;3212:1611-20. Neonatal maternal separation disrupts regulation of sleep and breathing in adult male rats. Kinkead R, Montandon G, Bairam A, Lajeunesse Y, Horner R.SourceCentre de Recherche du CHUQ, Hôpital St-François d’Assise, Université Laval, Québec, Canada. Richard.Kinkead@crsfa.ulaval.caAbstractSTUDY OBJECTIVES:Neonatal maternal separation NMS disrupts development of cardiorespiratory regulation. Adult male rats previously subjected to NMS are hypertensive and show a hypoxic ventilatory response greater than that of controls. These results have been … Continue reading

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