Tag Archives: China

Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds

Posted in Affective Neuroscience, epigenetics, Events, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News, Psychiatry/Neurology, Video | Tagged , , , , , , , , , , , | Comments Off on Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds

Invitation to my Grand Rounds Talk at Mount Sinai, Wednesday, October 9, 2013, 8am

Please join us for our next Neurology Grand Rounds on Wednesday, October 9th at 8 AM in Davis Auditorium (Hess Center for Science and Medicine) at 1470 Madison Ave between 101st and 102nd streets. Refreshments will be served at 7:30 AM so please feel free to arrive early.

Title: “Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology?”

Presenter: Dr. Maurice Preter, MD
Assistant Professor of Clinical Psychiatry,
Columbia’s College of Physicians and Surgeons;
Associate Professor of Neurology (Adj.),
SUNY Downstate Medical Center, Brooklyn, NY
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Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults.

12. J Am Geriatr Soc. 2009 May;57(5):871-6. Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults. Ng TP, Feng L, Niti M, Kua EH, Yap KB. Source Gerontological Research Programme, National University of Singapore, Department of Psychological Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore. pcmngtp@nus.edu.sg Abstract OBJECTIVES: To investigate the independent associations between folate, B12, and homocysteine levels and depressive symptoms in older adults. DESIGN: Cross-sectional study. SETTING: Resident population in southeast Singapore. PARTICIPANTS: Six … Continue reading

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Singapore: Lower dementia prevalence among ethnic Chinese compared to ethnic Malays and Indians.

Dement Geriatr Cogn Disord. 2010;30(6):492-8. doi: 10.1159/000321675. Epub 2011 Jan 20. Interethnic differences in dementia epidemiology: global and Asia-Pacific perspectives. Venketasubramanian N, Sahadevan S, Kua EH, Chen CP, Ng TP. Source Division of Neurology, University Medicine Cluster, and Department of Epidemiology and Public Health, National University Health System, National University of Singapore, 1E Kent Ridge Road, Singapore. ramani_nv@nuhs.edu.sg Abstract The burden of dementia will continue to rise globally, particularly in developing countries, many of which lie in the Asia-Pacific region. It was initially thought that … Continue reading

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Tea drinking and cognitive function in oldest-old Chinese.

J Nutr Health Aging. 2012;16(9):754-8. doi: 10.1007/s12603-012-0077-1. Tea drinking and cognitive function in oldest-old Chinese. Feng L, Li J, Ng TP, Lee TS, Kua EH, Zeng Y. Source Department of Psychological Medicine, National University of Singapore. pcmfl@nus.edu.sg Abstract OBJECTIVE: We examined the longitudinal association between tea drinking frequency and cognitive function in a large sample of oldest-old Chinese. DESIGN: population-based longitudinal cohort study. SETTING: The Chinese Longitudinal Healthy Longevity Survey (CLHLS). PARTICIPANTS: 7139 participants aged 80 to 115 (mean age 91.4 years) who provided complete … Continue reading

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Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis : The Lancet

“Our analysis suggests that previous estimates of dementia burden, based on smaller datasets, might have underestimated the burden of dementia in China.” Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990—2010: a systematic review and analysis Kit Yee Chan PhD a d, Wei Wang MPH b, Jing Jing Wu MPH b, Li Liu PhD c, Evropi Theodoratou PhD d, Josip Car PhD g, Prof Lefkos Middleton MD g, Tom C Russ MTCPsych e f h, Prof Ian J Deary FRSE e f, … Continue reading

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Scourge of depression sees rising number of suicides, report Cang Wei and Song Wenwei in Nanjing.

Staggering base rate… Dark days of despair drive many to the final option Updated: 2013-02-27 09:20 By Cang Wei and Song Wenwei in Nanjing/China Daily Scourge of depression sees rising number of suicides, report Cang Wei and Song Wenwei in Nanjing. Every three minutes, a person suffering from depression commits suicide in China and a further 11 people attempt to take their own lives.Every year in China, 287,000 people end their lives by suicide, while another 2 million contemplate the act, 70 percent of them … Continue reading

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Time to confront the global dementia crisis : The Lancet Neurology

Time to confront the global dementia crisis The Lancet Neurology High-income countries are not the only ones facing a dementia crisis as their populations age. According to the Alzheimer’s Disease International (ADI) Delphi consensus study, by 2040, 71% of all people with dementia will be living in developing countries. In addition to the personal devastation for these 58 million people and their families, the economic burden is likely to be immense: in this issue of The Lancet Neurology, Kalaria and colleagues estimate that the total … Continue reading

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1.7% of 65+ Chinese have Parkinson Disease, accounting for half of the world’s 200 million PD patients

我国每百名老人有1人患帕金森病 胡浩, 新华网 2012年4月16日 中国 今 年4月11日是第16个世界帕金森日。在14日举行的“健康小屋关爱行动”中,专家指出, 我国的帕金森患者已达200万,占全国老年人口的1%。为进一步提高帕金森病患者及其家人 的生活质量,专家建议在帕金森病患者和家庭中间推广正确的疾病管理知识和健康的生活方式, 为帕金森病患者营造一个安全舒适的家居环境。 北京协和医院神经科主任张振馨教授介绍,中国内地1.7%的65岁以上老年人深受帕金森病 的困扰。最新的流行病学调查显示,中国大陆地区的帕金森病患者已达200万,占全球帕金森 病患者总人数的一半。此外,临床数据显示,帕金森病正以每年10万新增病例的速度在我国递 增,成为继心脑血管疾病和老年痴呆症后严重威胁我国中老年人身心健康的“第三杀手”。 帕金森病是一种中老年人常见的中枢神经系统变性疾病,主要影响中老年人,多在50岁以后发 病。其运动症状表现为静止时肢体不自主地震颤、肌强直、运动迟缓以及姿势平衡障碍等,晚期 会导致患者生活不能自理。 由于行动迟缓及平衡障碍,帕金森病患者较常人更容易跌倒骨折,所以安全舒适的居家环境对帕 金森患者非常重要。 中华医学会北京神经病学分会帕金森病及运动障碍学组组长、卫生部北京医院神经内科主任陈海 波建议,为帕金森病患者营造“健康小屋”,即通过对起居室、厨房,卧室和浴室等家具设计和 摆放等生活环境中的细节改善,如采用杠杆式的门把手、选择不容易绊倒的轻便的整块地毯、将 卧床紧贴墙壁等,方便帕金森病患者的生活。 他还建议,为便于帕金森病患者起身和落座,椅子和沙发坐垫不宜过软,高度不宜过低。家具在 选择时应选择边角为圆钝弧形,以免患者跌倒受伤。

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A Call for Quality Care

A Call for Quality Care Employers are only now waking up to the bottom-line benefits of correct diagnoses and immediate and proper mental-health treatment for workers in need. By Drs. Maurice Preter and Jeffrey P. Kahn Tuesday, July 1, 2008 via Human Resource Executive Online | A Call for Quality Care.

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Depression program founded – Chinadaily.com.cn

Depression program founded|Cover Story|chinadaily.com.cn. Depression program founded Updated: 2012-09-12 07:51 By Shan Juan (China Daily) An onsite training program for physicians has been launched in major Chinese cities jointly by the Lundbeck Institute and the World Psychiatric Association to improve clinical knowledge of depression. The Ministry of Health estimates that 5 to 10 percent of the population suffers from depression. However, only 5 percent of sufferers have access to proper, timely treatment. “Apart from people’s reluctance to seek professional therapy, a lack of knowledge about … Continue reading

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