Tag Archives: demyelinating disease

Autoimmune disease, inflammation and the brain

Went to a fabulous lecture by  Dr. Souhel Najjar on autoimmune encephalitis this morning. As a reminder, bad relationships (including with one’s self-image etc.) can also cause/contribute to inflammatory burden. Below is a well-informed and written piece on Anti-NMDA-receptor encephalitis (one of many), courtesy of Wikipedia. Last edited 11 days ago by an anonymous user Anti-NMDA receptor encephalitis Watch this page Anti-NMDA (N-methyl D-aspartate) receptor antibody encephalitis, also termed NMDA receptor antibody encephalitis, is an acute form of encephalitis which is potentially lethal but has high probability for … Continue reading

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Identification of candidate IgG biomarkers for Alzheimer’s disease via combinatorial library screening.

This is important news. Cell. 2011 Jan 7;144(1):132-42. doi: 10.1016/j.cell.2010.11.054. Identification of candidate IgG biomarkers for Alzheimer’s disease via combinatorial library screening. Reddy MM, Wilson R, Wilson J, Connell S, Gocke A, Hynan L, German D, Kodadek T. Source Opko Health Laboratories, Jupiter, FL 33458, USA. Abstract The adaptive immune system is thought to be a rich source of protein biomarkers, but diagnostically useful antibodies remain unknown for a large number of diseases. This is, in part, because the antigens that trigger an immune response … Continue reading

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Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri.

Biol Pharm Bull. 2006 Sep;29(9):1976-9. Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri. Akihisa T, Tabata K, Banno N, Tokuda H, Nishimura R, Nakamura Y, Kimura Y, Yasukawa K, Suzuki T. Source College of Science and Technology, Nihon University, Tokyo, Japan. akihisa@chem.cst.nihon-u.ac.jp Erratum in Biol Pharm Bull. 2006 Dec;29(12):2536. Nishihara, Reiko [corrected to Nishimura, Reiko]. Abstract Fifteen triterpene acids, viz., seven of the beta-boswellic acids (ursane-type) (1-7), two of the alpha-boswellic acids (oleanane-type) (8, 9), two of … Continue reading

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Association between immediate initiation of intramuscular interferon beta-1a at the time of a clinically isolated syndrome and long-term outcomes: a 10-year follow-up of the Controlled High-Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurological Surveillance.

Arch Neurol. 2012 Feb;69(2):183-90. doi: 10.1001/archneurol.2011.1426. Epub 2011 Oct 10. Association between immediate initiation of intramuscular interferon beta-1a at the time of a clinically isolated syndrome and long-term outcomes: a 10-year follow-up of the Controlled High-Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurological Surveillance. Kinkel RP, Dontchev M, Kollman C, Skaramagas TT, O’Connor PW, Simon JH; Controlled High-Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurological Surveillance Investigators. Collaborators (24) Source Multiple Sclerosis Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline … Continue reading

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Cancer risk in multiple sclerosis: findings from British Columbia, Canada.

Good news but probably offset by use of immune-modulating/suppressive interventions (especially of cellular immunity) for MS. Do neurologists explain that to their patients? Another study to be done. Brain. 2012 Oct;135(Pt 10):2973-9. doi: 10.1093/brain/aws148. Epub 2012 Jun 21. Cancer risk in multiple sclerosis: findings from British Columbia, Canada. Kingwell E, Bajdik C, Phillips N, Zhu F, Oger J, Hashimoto S, Tremlett H. Source Division of Neurology, Faculty of Medicine, Multiple Sclerosis Program, University of British Columbia, Vancouver, British Columbia, Canada. elainejk@mail.ubc.ca Abstract Findings regarding cancer … Continue reading

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Modifiable factors influencing relapses and disability in multiple sclerosis.

Mult Scler. 2010 Jul;16(7):773-85. doi: 10.1177/1352458510367721. Epub 2010 May 18. Modifiable factors influencing relapses and disability in multiple sclerosis. D’hooghe MB, Nagels G, Bissay V, De Keyser J. Source National Center For Multiple Sclerosis, Melsbroek, Belgium. marie.dhooghe@ms-centrum.be Abstract A growing body of literature indicates that the natural course of multiple sclerosis can be influenced by a number of factors. Strong evidence suggests that relapses can be triggered by infections, the postpartum period and stressful life events. Vaccinations against influenza, hepatitis B and tetanus appear to … Continue reading

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Fingolimod treatment for multiple sclerosis patients What do we do with varicella?

Fingolimod treatment for multiple sclerosis patie… [Ann Neurol. 2011] – PubMed – NCBI. Ann Neurol. 2011 Oct;70(4):673-4; author reply 674. doi: 10.1002/ana.22605. Fingolimod treatment for multiple sclerosis patients What do we do with varicella? Winkelmann A, Loebermann M, Reisinger EC, Hartung HP, Zettl UK. Comment on Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis. [Ann Neurol. 2011] PMID: 22028236 [PubMed – indexed for MEDLINE] Publication Types, MeSH Terms, Substances LinkOut – more resources

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Melanoma occurring during treatment with fingo… [Arch Dermatol. 2011] – PubMed – NCBI

Arch Dermatol. 2011 Aug;147(8):991-2. doi: 10.1001/archdermatol.2011.212. Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. Conzett KB, Kolm I, Jelcic I, Kamarachev J, Dummer R, Braun R, French LE, Linnebank M, Hofbauer GF. PMID: 21844470 [PubMed – indexed for MEDLINE] Publication Types, MeSH Terms, Substances LinkOut – more resources via Melanoma occurring during treatment with fingo… [Arch Dermatol. 2011] – PubMed – NCBI.

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Delayed fingolimod-associated asystole. [Mult Scler. 2011] – PubMed – NCBI

Mult Scler. 2011 Nov;17(11):1387-9. doi: 10.1177/1352458511410344. Epub 2011 Jun 7. Delayed fingolimod-associated asystole. Espinosa PS, Berger JR. Source North Oaks Neurology, Hammond, LA, USA. ps.espinosa@gmail.com Abstract Oral fingolimod (Gilenya) is a sphingosine-1-phosphate-receptor modulator that prevents the egress of lymphocytes from lymph nodes. Fingolimod reduces relapses and delays disability progression in patients with relapsing forms of multiple sclerosis (MS). We report a patient with MS who developed asystole and sustained bradycardia 21 hours after the first dose of fingolimod. PMID: 21652609 [PubMed – indexed for MEDLINE] … Continue reading

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25-Hydroxyvitamin D, dementia, and cerebrovascular… [Neurology. 2010] – PubMed – NCBI

Neurology. 2010 Jan 5;74(1):18-26. doi: 10.1212/WNL.0b013e3181beecb7. Epub 2009 Nov 25. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, Qui WQ, Bergethon P, Rosenberg IH, Folstein MF, Patz S, Bhadelia RA, Tucker KL. Source Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St., Boston, MA 02111, USA. Abstract BACKGROUND: Vitamin D deficiency has potential adverse effects on neurocognitive health and subcortical function. However, no studies have examined … Continue reading

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Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study.

Lancet Neurol. 2011 May;10(5):436-45. doi: 10.1016/S1474-4422(11)70045-X. Epub 2011 Mar 31. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Banwell B, Bar-Or A, Arnold DL, Sadovnick D, Narayanan S, McGowan M, O’Mahony J, Magalhaes S, Hanwell H, Vieth R, Tellier R, Vincent T, Disanto G, Ebers G, Wambera K, Connolly MB, Yager J, Mah JK, Booth F, Sebire G, Callen D, Meaney B, Dilenge ME, Lortie A, Pohl D, Doja A, Venketaswaran S, Levin S, Macdonald … Continue reading

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A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon β-1b in patients with multiple sclerosis.

J Neurol Neurosurg Psychiatry. 2012 May;83(5):565-71. doi: 10.1136/jnnp-2011-301876. Epub 2012 Feb 22. A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon β-1b in patients with multiple sclerosis. Soilu-Hänninen M, Aivo J, Lindström BM, Elovaara I, Sumelahti ML, Färkkilä M, Tienari P, Atula S, Sarasoja T, Herrala L, Keskinarkaus I, Kruger J, Kallio T, Rocca MA, Filippi M. Source Department of Neurology, University of Turku, Turku, Finland. mersoi@utu.fi Abstract OBJECTIVES: To study the safety and efficacy of vitamin … Continue reading

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