Tag Archives: Depression

Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions

Important paper on childhood adversities an adult-age chronic medical conditions, published just before our study on endogenous opioid dysregulation after early childhood adversity in psychiatrically and physically “healthy” adults.   Archives of General Psychiatry August 2011, Vol 68, No. 8 > < Previous ArticleNext Article > Original Article | Aug 2011 Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions Kate M. Scott, PhD; Michael Von Korff, ScD; Matthias C. Angermeyer, MD, PhD; Corina Benjet, PhD; Ronny Bruffaerts, PhD; Giovanni de Girolamo, MD; Josep Maria Haro, MD, MPH, … Continue reading

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Coronary Heart Disease: Psychological Aspects

Psychological Aspects of Coronary Heart Disease: 126 Studies Published in 2012-2014 Another useful resource provided by the page of Kenneth S. Pope, Ph.D. ABPP, including gems like: Vlachaki, C. and K. Maridaki Kassotaki (2013). “Coronary heart disease and emotional intelligence.” Glob J Health Sci 5(6): 156-165.

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Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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Parental olfactory experience influences behavior and neural structure in subsequent generations : Nature Neuroscience

Nature Neuroscience  Parental olfactory experience influences behavior and neural structure in subsequent generations Brian G Dias & Kerry J Ressler Affiliations Contributions Corresponding authors Nature Neuroscience (2013) doi:10.1038/nn.3594 Received 21 September 2013 Accepted 01 November 2013 Published online 01 December 2013 Article tools Citation Reprints Rights & permissions Article metrics Abstract Abstract• References• Author information• Supplementary information Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor … Continue reading

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Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life

Meta-Analyses: Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life. Another gem from Dr. Ken Pope’s web site.    

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China ‘Catastrophe’ Hits 114 Million as Diabetes Spreads

Given the link between DM II and dementia, previous estimates of China’s coming dementia burden may need to be adjusted. See also: http://psychiatryneurology.net/news/time-to-confront-the-global-dementia-crisis-the-lancet-neurology/ >>The most comprehensive nationwide survey for diabetes ever conducted in China shows 11.6 percent of adults, or 114 million, has the disease. The finding, published yesterday in the Journal of the American Medical Association, adds 22 million diabetics, or the population of Australia, to a 2007 estimate and means almost one in three diabetes sufferers globally is in China.<< [Full text at … Continue reading

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Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults.

12. J Am Geriatr Soc. 2009 May;57(5):871-6. Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults. Ng TP, Feng L, Niti M, Kua EH, Yap KB. Source Gerontological Research Programme, National University of Singapore, Department of Psychological Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore. pcmngtp@nus.edu.sg Abstract OBJECTIVES: To investigate the independent associations between folate, B12, and homocysteine levels and depressive symptoms in older adults. DESIGN: Cross-sectional study. SETTING: Resident population in southeast Singapore. PARTICIPANTS: Six … Continue reading

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Singapore: Lower dementia prevalence among ethnic Chinese compared to ethnic Malays and Indians.

Dement Geriatr Cogn Disord. 2010;30(6):492-8. doi: 10.1159/000321675. Epub 2011 Jan 20. Interethnic differences in dementia epidemiology: global and Asia-Pacific perspectives. Venketasubramanian N, Sahadevan S, Kua EH, Chen CP, Ng TP. Source Division of Neurology, University Medicine Cluster, and Department of Epidemiology and Public Health, National University Health System, National University of Singapore, 1E Kent Ridge Road, Singapore. ramani_nv@nuhs.edu.sg Abstract The burden of dementia will continue to rise globally, particularly in developing countries, many of which lie in the Asia-Pacific region. It was initially thought that … Continue reading

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Tea drinking and cognitive function in oldest-old Chinese.

J Nutr Health Aging. 2012;16(9):754-8. doi: 10.1007/s12603-012-0077-1. Tea drinking and cognitive function in oldest-old Chinese. Feng L, Li J, Ng TP, Lee TS, Kua EH, Zeng Y. Source Department of Psychological Medicine, National University of Singapore. pcmfl@nus.edu.sg Abstract OBJECTIVE: We examined the longitudinal association between tea drinking frequency and cognitive function in a large sample of oldest-old Chinese. DESIGN: population-based longitudinal cohort study. SETTING: The Chinese Longitudinal Healthy Longevity Survey (CLHLS). PARTICIPANTS: 7139 participants aged 80 to 115 (mean age 91.4 years) who provided complete … Continue reading

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Finasteride induced depression: a prospective study.

Finasteride induced depression: a prospective study. Rahimi-Ardabili B, Pourandarjani R, Habibollahi P, Mualeki A. Source Clinical Pharmacy Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ba.rahimi@gmail.com Abstract BACKGROUND: Finasteride is a competitive inhibitor of 5 alpha-reductase enzyme, and is used for treatment of benign prostatic hyperplasia and androgenetic alopecia. Animal studies have shown that finasteride might induce behavioral changes. Additionally, some cases of finasteride-induceddepression have been reported in humans. The purpose of this study was to examine whether depressive symptoms or anxiety might be induced byfinasteride administration. METHODS: One hundred and twenty eight men … Continue reading

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Finasteride treatment influences neuronal plasticity on a structural level. These changes might contribute to the pathophysiology of depressive episodes observed after finasteride treatment.

Pharmacopsychiatry. 2010 Jul;43(5):174-8. doi: 10.1055/s-0030-1249095. Epub 2010 May 18. Finasteride treatment inhibits adult hippocampal neurogenesis in male mice. Römer B, Pfeiffer N, Lewicka S, Ben-Abdallah N, Vogt MA, Deuschle M, Vollmayr B, Gass P. Source RG Behavioural Biology, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany. benedikt.roemer@zi-mannheim.de Abstract INTRODUCTION: The 5-alpha-reductase inhibitor finasteride is used for the treatment of androgenic alopecia, benign prostate hyperplasia and prostate cancer. Besides inhibiting the conversion of testosterone to the biologically more active 5alpha-dihydrotestosterone, it also inhibits the production of neurosteroids. Decreased neurosteroid levels are postulated to be involved … Continue reading

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Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.

Phytother Res. 2013 Jul 6. doi: 10.1002/ptr.5025. [Epub ahead of print] Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial. Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Source Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India. Abstract Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential antidepressant-like activity in animal studies. The objectives of this trial were to compare the efficacy and safety of curcumin with fluoxetine in … Continue reading

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