Tag Archives: endogenous opioids

A Proactive Response to Prescription Opioid Abuse

A Proactive Response to Prescription Opioid Abuse Robert M. Califf, M.D., Janet Woodcock, M.D., and Stephen Ostroff, M.D. February 4, 2016DOI: 10.1056/NEJMsr1601307 http://tinyurl.com/godfdoc We at the Food and Drug Administration (FDA) continue to be deeply concerned about the growing epidemic of opioid abuse, addiction, and overdose — an epidemic directly related to the increasingly widespread misuse of powerful opioid pain medications. As the federal agency charged with ensuring that the drugs used by the U.S. public are both effective and safe, we are committed to … Continue reading

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New Book Alert: Panic Disorder: Neurobiological and Treatment Aspects

Panic Disorder/Psychiatry Home > Medicine > Psychiatry SUBDISCIPLINES JOURNALS BOOKS SERIES TEXTBOOKS REFERENCE WORKS Panic Disorder Neurobiological and Treatment Aspects Nardi, Antonio Egidio, Freire, Rafael Christophe R (Eds.) 2015, Approx. 300 p. 20 illus., 5 illus. in color. Available Formats: eBook Information Hardcover Information approx. $189.00 (net) price for USA ISBN 978-3-319-12537-4 free shipping for individuals worldwide Due: July 25, 2015   add to marked items Tweet ABOUT THIS BOOK AUTHORS & EDITORS All updated neurobiological aspects in just one book Researchers from different countries working together Psychopharmacological aspects based on research … Continue reading

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Special issue on panic disorder: Actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.

This is the final, published version of our paper, published in the special issue of Neuroscience & Biobehavioral Reviews Volume 46, Part 3, October 2014, Pages 345–351 Translational approaches to panic disorder http://www.sciencedirect.com/science/article/pii/S0149763414000827 PDF: Preter Klein 2014 final journal version Nov 20 2014  FULLTEXT:  Article outline Highlights Abstract Keywords 1. Panic and comorbid conditions 2. Testing the panic-suffocation-false alarm-endogenous opioid connection References Neuroscience & Biobehavioral Reviews Volume 46, Part 3, October 2014, Pages 345–351 Translational approaches to panic disorder Review Lifelong opioidergic vulnerability through early life … Continue reading

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The relationship between childhood parental loss and metabolic syndrome in obese subjects.

Pro-inflammatory effects of CPL? [M]ultivariate logistic regression analysis revealed that both childhood loss of a parent and a body mass index (BMI) value greater than 50 were significant predictors of metabolic syndrome. This study provides preliminary evidence linking childhood parental loss to risk factors for the development of metabolic syndrome. Continue reading

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Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions

Important paper on childhood adversities an adult-age chronic medical conditions, published just before our study on endogenous opioid dysregulation after early childhood adversity in psychiatrically and physically “healthy” adults.   Archives of General Psychiatry August 2011, Vol 68, No. 8 > < Previous ArticleNext Article > Original Article | Aug 2011 Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions Kate M. Scott, PhD; Michael Von Korff, ScD; Matthias C. Angermeyer, MD, PhD; Corina Benjet, PhD; Ronny Bruffaerts, PhD; Giovanni de Girolamo, MD; Josep Maria Haro, MD, MPH, … Continue reading

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Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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Parental olfactory experience influences behavior and neural structure in subsequent generations : Nature Neuroscience

Nature Neuroscience  Parental olfactory experience influences behavior and neural structure in subsequent generations Brian G Dias & Kerry J Ressler Affiliations Contributions Corresponding authors Nature Neuroscience (2013) doi:10.1038/nn.3594 Received 21 September 2013 Accepted 01 November 2013 Published online 01 December 2013 Article tools Citation Reprints Rights & permissions Article metrics Abstract Abstract• References• Author information• Supplementary information Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor … Continue reading

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Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life

Meta-Analyses: Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life. Another gem from Dr. Ken Pope’s web site.    

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Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds

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Invitation to my Grand Rounds Talk at Mount Sinai, Wednesday, October 9, 2013, 8am

Please join us for our next Neurology Grand Rounds on Wednesday, October 9th at 8 AM in Davis Auditorium (Hess Center for Science and Medicine) at 1470 Madison Ave between 101st and 102nd streets. Refreshments will be served at 7:30 AM so please feel free to arrive early.

Title: “Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology?”

Presenter: Dr. Maurice Preter, MD
Assistant Professor of Clinical Psychiatry,
Columbia’s College of Physicians and Surgeons;
Associate Professor of Neurology (Adj.),
SUNY Downstate Medical Center, Brooklyn, NY
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Social pain–the painful feelings associated with social disconnection–rely on some of the same neurobiological substrates that underlie experiences of physical pain

Nat Rev Neurosci. 2012 May 3;13(6):421-34. doi: 10.1038/nrn3231. The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Eisenberger NI. Source University of California, Department of Psychology, 4444 Franz Hall, Los Angeles, California 90095, USA. neisenbe@ucla.edu Abstract Experiences of social rejection, exclusion or loss are generally considered to be some of the most ‘painful’ experiences that we endure. Indeed, many of us go to great lengths to avoid situations that may engender these experiences (such as public speaking). Why is … Continue reading

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An endogenous opioid deficiency/expanded suffocation false alarm theory model of panic disorder.

These are the slides from my  talk at the First International Symposium on Translational Models of Panic Disorder. Vitoria, ES, Brazil, November 16-18, 2012.

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