Tag Archives: Inflammation

Alzheimer’s Disease – what is it and how can it be treated?

Alzheimer’s Disease – what is it and how can it be treated? Continue reading

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Dementia and Alzheimers’ Disease – How Can It Be Treated?

Dementia and Alzheimers’ Disease – How Can It Be Treated?

The Latin word “De-mentia”, literally means, the removal of a person from their own mind. It stands for a significant decrease in brain function, including memory, goal-directed thinking, orientation in space and time, and language ability.

Most dementias are progressive. They cannot be cured and will gradually cause more severe problems for the patient, and for the patient’s caretakers. As the population ages, Alzheimer’s disease is on its way to becoming the third most common fatal disease.

Prescription medications on the market starting in the 1990s to treat dementia have been a disappointment to patients and doctors alike.

The frustration caused by this situation prompted me to make the development of an anti-dementia treatment protocol a major focus of my clinical work.

As always, we start with a thorough neuropsychiatric assessment, looking for potentially reversible causes of cognitive decline such as a thyroid condition, vitamin deficiency, a sleep disorder, elevated blood sugar and diabetes. Importantly, untreated depression and chronic high stress and anxiety levels are associated with a higher risk for dementia. Most of the time, psychotherapy is a far better alternative to the all-too-common multiple prescription drugs.

The protocol uses a number of carefully evaluated novel interventions and components based on sound neuroscientific principles, sourced from both functional medicine and traditional medical systems, such as Ayurvedic and traditional Chinese medicine.

The protocol stabilizes many of my patients, and improves their functioning and quality of life. It has shown promising results not only for dementia, but also for traumatic brain injury. Continue reading

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Multimodal randomized Functional MR imaging of the effects of Methylene Blue in the human Brain

Multimodal randomized Functional MR imaging of the effects of Methylene Blue in the human Brain A new treatment for short-term memory loss? Or radiological gadgetry? Purpose To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain. Materials and Methods The institutional review board approved this prospective, HIPAA-compliant, randomized, double-blinded, placebo-controlled clinical trial, and all patients provided informed consent. Twenty-six subjects (age range, 22–62 years) were enrolled. Functional magnetic resonance (MR) imaging was performed with a … Continue reading

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Arthritis and suicide attempts: findings from a large nationally representative Canadian survey

Arthritis and suicide attempts: findings from a large nationally representative Canadian survey The objectives of this study were (1) to determine the odds of suicide attempts among those with arthritis compared with those without and to see what factors attenuate this association and (2) to identify which factors are associated with suicide attempts among adults with arthritis. Secondary data analysis of the nationally representative 2012 Canadian Community Health Survey-Mental Health (CCHS-MH) was performed. For objective 1, those with and without arthritis were included (n = 21,744). For … Continue reading

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Periodontitis and Cognitive Decline in Alzheimer’s Disease

Periodontitis and Cognitive Decline in Alzheimer’s Disease Continue reading

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Magnesium intake decreases Type 2 diabetes Risk through the Improvement of Insulin Resistance and Inflammation

  Magnesium intake decreases Type 2 diabetes Risk through the Improvement of Insulin Resistance and Inflammation http://tinyurl.com/zjbvklt MEDLINE Abstract Hata A ; Doi Y ; Ninomiya T ; Mukai N ; Hirakawa Y ; Hata J ; Ozawa M ; Uchida K ; Shirota T ; Kitazono T ; Kiyohara Y AIMS: Early studies have shown that magnesium intake decreases the risk of Type 2 diabetes, but the results are still inconsistent. We prospectively examined the association between magnesium intake and incidence of Type 2 diabetes … Continue reading

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Can Vitamin D Benefit Patients with Prediabetes?

Can Vitamin D Benefit Patients with Prediabetes? No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial Henrik Wagner1⇑, Michael Alvarsson1, Buster Mannheimer2, Marie Degerblad1 and Claes Göran Östenson1 http://care.diabetesjournals.org/content/early/2016/01/07/dc15 -1057.abstract Abstract OBJECTIVE There has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis. This study was designed to investigate the effect of high-dose vitamin D3 treatment on β-cell function, insulin sensitivity, and glucose tolerance in subjects with prediabetes or … Continue reading

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Quetiapine safety in older adults?

Quetiapine safety in older adults? Journal of Clinical Pharmacy and Therapeutics Volume 41,  Issue 1, pages 7–18, February 2016 http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12357/abstract Abstract WHAT IS KNOWN AND OBJECTIVE: Quetiapine is a second-generation antipsychotic that is commonly prescribed for a range of approved and off-label indications in older adults. However, little is known about its safety in this population. The available evidence on quetiapine safety is based on studies on second-generation antipsychotics as a group, often in the general population and for approved indications. There are no systematicreviews on the safety … Continue reading

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A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-28 Ingrid Van der Auwera, Stefaan Wera, Fred Van Leuven and Samuel T HendersonEmail author Nutrition & Metabolism20052:28 DOI: 10.1186/1743-7075-2-28 ©  Van der Auwera et al; licensee BioMed Central Ltd. 2005 Received: 09 August 2005 Accepted: 17 October 2005 Published: 17 October 2005 Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and development of AD. Yet, these studies did … Continue reading

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Neuroprotective and disease-modifying effects of the ketogenic diet

Neuroprotective and disease-modifying effects of the ketogenic diet Behav Pharmacol. Author manuscript; available in PMC 2008 May 5. Published in final edited form as: Behav Pharmacol. 2006 Sep; 17(5-6): 431–439. Reading it again.. Well worth it. Abstract The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer long-lasting therapeutic benefits for patients with epilepsy. Moreover, there is evidence from uncontrolled … Continue reading

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Coconut Oil for Alzheimer’s Disease

The NIH is recruiting for a randomized study to determine the efficacy of coconut oil as a possible treatment for older adults with mild to moderate Alzheimer’s disease. Continue reading

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Serotonin and the marketing of a depression myth

Serotonin and the marketing of a depression myth Serotonin and depression BMJ 2015; 350 doi: http://dx.doi.org.ezproxy.cul.columbia.edu/10.1136/bmj.h1771 (Published 21 April 2015)Cite this as: BMJ 2015;350:h1771  Article Related content Metrics Responses David Healy, professor of psychiatry Author affiliations david.healy54@googlemail.com The marketing of a myth The serotonin reuptake inhibiting (SSRI) group of drugs came on stream in the late 1980s, nearly two decades after first being mooted. The delay centred on finding an indication. They did not have hoped for lucrative antihypertensive or antiobesity profiles. A 1960s idea that serotonin concentrations might be lowered … Continue reading

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