Tag Archives: informed consent

Alzheimer’s Disease – what is it and how can it be treated?

Alzheimer’s Disease – what is it and how can it be treated? Continue reading

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Can Vitamin D Benefit Patients with Prediabetes?

Can Vitamin D Benefit Patients with Prediabetes? No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial Henrik Wagner1⇑, Michael Alvarsson1, Buster Mannheimer2, Marie Degerblad1 and Claes Göran Östenson1 http://care.diabetesjournals.org/content/early/2016/01/07/dc15 -1057.abstract Abstract OBJECTIVE There has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis. This study was designed to investigate the effect of high-dose vitamin D3 treatment on β-cell function, insulin sensitivity, and glucose tolerance in subjects with prediabetes or … Continue reading

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True Risk of Serious Harms with Antidepressants Still Uncertain

True Risk of Serious Harms with Antidepressants Still Uncertain http://www.bmj.com/content/352/bmj.i65 Abstract Objective To study serious harms associated with selective serotonin and serotonin-norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main outcome measures Mortality and suicidality. Secondary outcomes were aggressive behaviour and akathisia. Data sources Clinical study reports for duloxetine, fluoxetine, paroxetine, sertraline, and venlafaxine obtained from the European and UK drug regulators, and summary trial reports for duloxetine and fluoxetine from Eli Lilly’s website. Eligibility criteria for study selection Double blind placebo controlled trials that contained any patient narratives or … Continue reading

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Quetiapine safety in older adults?

Quetiapine safety in older adults? Journal of Clinical Pharmacy and Therapeutics Volume 41,  Issue 1, pages 7–18, February 2016 http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12357/abstract Abstract WHAT IS KNOWN AND OBJECTIVE: Quetiapine is a second-generation antipsychotic that is commonly prescribed for a range of approved and off-label indications in older adults. However, little is known about its safety in this population. The available evidence on quetiapine safety is based on studies on second-generation antipsychotics as a group, often in the general population and for approved indications. There are no systematicreviews on the safety … Continue reading

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Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition.

  Richard Carlton MD asked me to post abstracts related to the well-established but under-appreciated dopamine-blocking effect of metoclopramide. Ned Tijdschr Geneeskd. 2013;157(26):A6037. Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition. [Article in Dutch] de Ronde MW1, Kingma HJ, Munts AG. Author information 1Kennemer Gasthuis, afd. Neurologie, Haarlem, the Netherlands. mwjderonde@gmail.com Abstract In this article, we present 3 women aged 73, 85 and 88 years who developed metoclopramide-induced parkinsonism. Shortly after starting metoclopramide, bradykinesia and rigidity developed in all 3 patients; tremor and postural instability … Continue reading

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A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-28 Ingrid Van der Auwera, Stefaan Wera, Fred Van Leuven and Samuel T HendersonEmail author Nutrition & Metabolism20052:28 DOI: 10.1186/1743-7075-2-28 ©  Van der Auwera et al; licensee BioMed Central Ltd. 2005 Received: 09 August 2005 Accepted: 17 October 2005 Published: 17 October 2005 Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and development of AD. Yet, these studies did … Continue reading

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Risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy

The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: A systematic review and meta-analysis   http://onlinelibrary.wiley.com/doi/10.1111/bcp.12849/abstract Anick Bérard1,2,*, Noha Iessa1,2, Sonia Chaabane1,2, Flory T. Muanda1,2, Takoua Boukhris1,2 and Jin-Ping Zhao1,2 DOI: 10.1111/bcp.12849 This article is protected by copyright. All rights reserved. Issue British Journal of Clinical Pharmacology Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) Additional Information(Show All) Author InformationPublication History This article has been accepted for … Continue reading

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Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease http://archinte.jamanetwork.com/article.aspx?articleid=2481157 Benjamin Lazarus, MBBS1,2; Yuan Chen, MS1; Francis P. Wilson, MD, MS3; Yingying Sang, MS1; Alex R. Chang, MD, MS4; Josef Coresh, MD, PhD1,5; Morgan E. Grams, MD, PhD1,5 [+] Author Affiliations JAMA Intern Med. Published online January 11, 2016. doi:10.1001/jamainternmed.2015.7193 Text Size: A A A ABSTRACT ABSTRACT | INTRODUCTION | METHODS | RESULTS | DISCUSSION | CONCLUSIONS |ARTICLE INFORMATION | REFERENCES Importance  Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI use and chronic kidney disease (CKD). Objective  To quantify the association between PPI use and … Continue reading

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Meta-analyses with industry involvement are massively published and report no caveats for antidepressants.

CONCLUSION:

There is a massive production of meta-analyses of antidepressants for depression authored by or linked to the industry, and they almost never report any caveats about antidepressants in their abstracts. Our findings add a note of caution for meta-analyses with ties to the manufacturers of the assessed products. Continue reading

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Benzodiazepine use and risk of Alzheimer’s disease

Benzodiazepine use is associated with an increased risk of Alzheimer’s disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern. Continue reading

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Benzodiazepine use associated with increased risk of dementia.

Conclusions In this prospective population based study, new use of benzodiazepines was associated with increased risk of dementia. The result was robust in pooled analyses across cohorts of new users of benzodiazepines throughout the study and in a complementary case-control study. Considering the extent to which benzodiazepines are prescribed and the number of potential adverse effects of this drug class in the general population, indiscriminate widespread use should be cautioned against. Continue reading

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Neuroprotective and disease-modifying effects of the ketogenic diet

Behav Pharmacol. 2006 Sep; 17(5-6): 431–439.  PMCID: PMC2367001 NIHMSID: NIHMS42857 Neuroprotective and disease-modifying effects of the ketogenic diet Maciej Gasior,a Michael A. Rogawski,a and  Adam L. Hartmana,b Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Behav Pharmacol See other articles in PMC that cite the published article. Go to: Abstract The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer … Continue reading

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