Is Particulate Matter of Air Pollution a Vector of Covid-19 Pandemic?

Summary
The COVID-19 pandemic is a severe respiratory disease caused by the emergence of a new coronavirus, SARS-CoV-2, that very quickly spread in the human population. Fine particulate matter (PM) generated from combustion engines have been described as toxic to human health. Recent events stressed that high concentrations of PM of air pollution might favor the spread of SARS-CoV-2. Autumn approaches, air pollution will be accentuated because of weather condition. The risk of a second outbreak of Covid-19 pandemic is highly probable. Elucidating the role of PM of air pollution in the spread of the virus is thus urgent and crucial. Continue reading

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Dietary buckwheat enhances sirtuin1 without calorie restriction

This is truly excellent news, at least for каша lovers.  Abstract In the present investigation, the role of dietary intervention in male Wistar rats (n = 8, 3 groups) was studied to observe absolute sirtuin 1 (SIRT1) levels (expressed as ng mg−1 total … Continue reading

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Leisure time aerobic and muscle strengthening activities are associated with important survival benefits.

Adults who engage in leisure time aerobic and muscle strengthening activities at levels recommended by the 2018 physical activity guidelines for Americans show greatly reduced risk of all cause and cause specific mortality. These data suggest that the physical activity levels recommended in the guidelines are associated with important survival benefits. Continue reading

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The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds – Additional weapons in the fight against the COVID-19 pandemic?

Abstract
Introduction

As of March 11th, 2020, the World Health Organization declared the COVID-19 outbreak a pandemic. Articles published after the SARS-CoV-1 (2002) epidemic suggest that the use of an herbal-drug integrative medical approach could have contributed to a lower fatality rate and a more rapid response in controlling the outbreak.

Methods

Pubmed was searched for articles that investigated the antiviral properties and mechanisms of action of herbs or natural compounds against the SARS-coronavirus (CoV).

Results

Forty-three (43) relevant papers were located. A general count rendered 450+ herbs and natural compounds with antiviral properties against the SARS-CoV and related viruses. From the 43 articles, thirty-one (31) uncovered the mechanisms of action of the natural substances able to oppose the coronavirus.

Discussion

A series of herbs and natural compounds demonstrated moderate to strong antiviral activity. Research on many herbs-natural compounds also showed potent and significant inhibition of CoV-host protein pathways responsible for different phases of viral replication specifically targeting 3CLPRO, PLPRO, RdRp, helicase protein, S protein, N protein, 3a protein, Cathepsin L, Nsp1, Nsp3c, and ORF7a, and the S protein/ACE-2 interaction.

Conclusion

The herbs-natural compounds with antiviral activity and that caused inhibition/blockade of the CoV-host protein pathways are potential therapeutic candidates. The homology between the SARS-CoV-1 and SARS-CoV-2 is around 80%. Thus, effective herbs-compounds for the former would likely be beneficial for the latter also depending on target protein similarities between the viruses. Here we provide the mechanistic bases supporting an integrative approach that includes natural compounds to fight coronavirus infections.

Keywords: Coronavirus, COVID-19, Herbs, Natural compounds, Antiviral, Pandemic Continue reading

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Review  Volume 179, Issue 2, pp. 312-339, October 3, 2019 Justin M. Long David M. Holtzman References Article Info Published: September 26, 2019DOI:https://doi.org/10.1016/j.cell.2019.09.001 Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition … Continue reading

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