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Tag Archives: medically unexplained symptoms
Panic Attacks and Panic Disorder – what is it and how can it be treated? Continue reading
[nihms] Manuscript #585187: Your manuscript is available in PMC Dear Maurice Preter, Manuscript NIHMS585187 (“Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder”) has been loaded into PubMed Central (PMC) and made available for public access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195810 The submission process for this manuscript is now complete. We encourage you to make further manuscript submissions as they become eligible. As always, please feel free to contact the NIHMS Help Desk with any questions at http://www.nihms.nih.gov/db/sub.cgi?page=email. Thank you … Continue reading
Went to a fabulous lecture by Dr. Souhel Najjar on autoimmune encephalitis this morning. As a reminder, bad relationships (including with one’s self-image etc.) can also cause/contribute to inflammatory burden. Below is a well-informed and written piece on Anti-NMDA-receptor encephalitis (one of many), courtesy of Wikipedia. Last edited 11 days ago by an anonymous user Anti-NMDA receptor encephalitis Watch this page Anti-NMDA (N-methyl D-aspartate) receptor antibody encephalitis, also termed NMDA receptor antibody encephalitis, is an acute form of encephalitis which is potentially lethal but has high probability for … Continue reading
Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions
Important paper on childhood adversities an adult-age chronic medical conditions, published just before our study on endogenous opioid dysregulation after early childhood adversity in psychiatrically and physically “healthy” adults. Archives of General Psychiatry August 2011, Vol 68, No. 8 > < Previous ArticleNext Article > Original Article | Aug 2011 Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions Kate M. Scott, PhD; Michael Von Korff, ScD; Matthias C. Angermeyer, MD, PhD; Corina Benjet, PhD; Ronny Bruffaerts, PhD; Giovanni de Girolamo, MD; Josep Maria Haro, MD, MPH, … Continue reading
Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.
“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading
Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds
North Shore-Lenox Hill Hospital Neurology Grand Rounds on May 21, 2013 Topic: Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: How panic research can inform clinical neurology.
I will be giving North Shore-Lenox Hill Hospital Neurology Grand Rounds on May 21, 2013 – all invited! Topic: Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: How panic research can inform clinical neurology. Speaker: Maurice Preter, MD Date: 5/21/2013 Time: 8:30-9:30 AM Location: 2nd Floor Achelis Conference Room [PDF is here: North Shore flyer may 21] Learning Objectives: Upon completion of this session, participants should be able to: 1) Understand research on panic and separation anxiety 2) Be able to apply … Continue reading