Tag Archives: Medication effects – wanted and unwanted

Benzodiazepine use and risk of Alzheimer’s disease

Benzodiazepine use is associated with an increased risk of Alzheimer’s disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern. Continue reading

Posted in Aging, China, Events, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News, Psychiatry/Neurology | Tagged , , , , , | Comments Off on Benzodiazepine use and risk of Alzheimer’s disease

Benzodiazepine use associated with increased risk of dementia.

Conclusions In this prospective population based study, new use of benzodiazepines was associated with increased risk of dementia. The result was robust in pooled analyses across cohorts of new users of benzodiazepines throughout the study and in a complementary case-control study. Considering the extent to which benzodiazepines are prescribed and the number of potential adverse effects of this drug class in the general population, indiscriminate widespread use should be cautioned against. Continue reading

Posted in Aging, China, Events, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News, Psychiatry/Neurology | Tagged , , , , | Comments Off on Benzodiazepine use associated with increased risk of dementia.

Hyperglycemia is associated with subtle brain injury and impaired attention and memory even in young adults

Neurology. 2015 Jun 9;84(23):2329-37. doi: 10.1212/WNL.0000000000001655. Epub 2015 May 6. Glucose indices are associated with cognitive and structural brain measures in young adults. Weinstein G1, Maillard P2, Himali JJ2, Beiser AS2, Au R2, Wolf PA2, Seshadri S2, DeCarli C2. Author information Abstract OBJECTIVE: To evaluate the possible early consequences of impaired glucose metabolism on the brain by assessing the relationship of diabetes, fasting blood glucose (FBG) levels, and insulin resistance with cognitive performance and brain integrity in healthy young and middle-aged adults. METHODS: The sample included dementia-free participants (mean age 40 ± 9 … Continue reading

Posted in Aging, China, dietary, epigenetics, Events, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News, Psychiatry/Neurology | Tagged , , , , , | Comments Off on Hyperglycemia is associated with subtle brain injury and impaired attention and memory even in young adults

Association between benzodiazepine use and occurrence of benign brain tumors.

J Neurol Sci. 2014 Jan 15;336(1-2):8-12. doi: 10.1016/j.jns.2013.11.009. Epub 2013 Nov 16. An association between benzodiazepine use and occurrence of benign brain tumors. Harnod T1, Lin CL2, Sung FC2, Kao CH3. Author information Abstract OBJECTIVE: This study was designed to evaluate the impact of long-term benzodiazepine use on the subsequent risk of benign brain tumor (BBT) or malignant brain tumor (MBT) development. METHOD: We used data from the National Health Insurance System of Taiwan. For the study cohort, we identified 62,186 patients who had been prescribed benzodiazepine for at least 2 … Continue reading

Posted in Aging, epigenetics, Events, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News, Psychiatry/Neurology | Tagged , , , | Comments Off on Association between benzodiazepine use and occurrence of benign brain tumors.

BMJ.org: Research News Benzodiazepines may be linked to Alzheimer’s disease, study finds

Research News Benzodiazepines may be linked to Alzheimer’s disease, study finds BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g5555 (Published 10 September 2014)Cite this as: BMJ 2014;349:g5555 Article Related content Metrics Responses Get access to this article and to all of thebmj.com for 14 days. Sign up today for a 14 day free trial. Access to the full version of this article requires a subscription payment. Please login or subscribe below. Zosia Kmietowicz Author affiliations Taking benzodiazepines is associated with an increased risk of developing Alzheimer’s disease, particularly in long term users, a study has … Continue reading

Posted in Aging, China, Complementary - Alternative Medicine, Events, Forensic Neuropsychiatry, International And Concierge Medicine, Psychiatry/Neurology | Tagged , , , , | Comments Off on BMJ.org: Research News Benzodiazepines may be linked to Alzheimer’s disease, study finds

Sildenafil Use and Increased Risk of Inciden… [JAMA Intern Med. 2014] – PubMed – NCBI

JAMA Intern Med. 2014 Jun 1;174(6):964-70. doi: 10.1001/jamainternmed.2014.594. Sildenafil Use and Increased Risk of Incident Melanoma in US Men: A Prospective Cohort Study. Li WQ1, Qureshi AA2, Robinson KC3, Han J4. Author information Abstract IMPORTANCE The RAS/RAF/mitogen-activated protein kinase and extracellular signal-regulated kinase (ERK) kinase/ERK cascade plays a crucial role in melanoma cell proliferation and survival. Sildenafil citrate (Viagra) is a phosphodiesterase (PDE) 5A inhibitor commonly used for erectile dysfunction. Recent studies have shown that BRAF activation down-regulates PDE5A levels, and low PDE5A expression by … Continue reading

Posted in Aging, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News | Tagged , | Comments Off on Sildenafil Use and Increased Risk of Inciden… [JAMA Intern Med. 2014] – PubMed – NCBI

The top online health services for consumers | VentureBeat | Health | by Christina Farr

Interesting line-up of online medical shopping/info sites. Some might offer some relief from/price-conscious alternatives to emergency room visits. Perhaps good news for U.S. patients facing gigantic out-of-pocket expenses for not-sure-what value-add, a worldwide market for digital medical tourism for low-complexity medical care is emerging (see for instance, here https://ring.md/) On the other hand, I don’t see how these digital med-tech sites can replace (i.e., provide relief for the increasingly felt absence of ) expertise-through-experience based doctoring, with true, trust-based, long-term doctor-patient rapport. The top online … Continue reading

Posted in Events, Fifth Avenue Concierge Medicine, Health, News, Uncategorized | Tagged , | Comments Off on The top online health services for consumers | VentureBeat | Health | by Christina Farr

The Selling of Attention Deficit Disorder – NYTimes.com

Surprisingly critical, thoroughly researched piece by Alan Schwarz. See also recent posts here (on opening the gigantic Asian market to Western psychotropics), here (on Allen Roses critique of drug efficacy), here (on the DSM V’s focus on, well, drug treatment), here on Allen Frances’ DSM V cost predictions, here (on other types of Western toxic waste profitably deposited in the anything-goes Chinese market), my own alternative views on medical-psychiatric diagnosis and care here and here. Health Log In Register Now Help The Selling of Attention … Continue reading

Posted in China, development, Events, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News, Psychiatry/Neurology | Tagged , , | Comments Off on The Selling of Attention Deficit Disorder – NYTimes.com

A senior executive with Britain’s biggest drugs company has admitted that most prescription medicines do not work on most people who take them. Science – News – The Independent

I just had the great pleasure of meeting Allen Roses. The 2003 article quoted is a reminder of “plus ca change, plus c’est la meme chose”. Glaxo chief: Our drugs do not work on most patients – Science – News – The Independent.    

Posted in epigenetics, Events, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Psychiatry/Neurology, Uncategorized | Tagged , , | Comments Off on A senior executive with Britain’s biggest drugs company has admitted that most prescription medicines do not work on most people who take them. Science – News – The Independent

Metabolic Fate of Pharmaceuticals: A Focus on Slow Metabolizers

Very interesting and timely PowerPoint focusing on (now increasingly preventable) adverse outcomes, not on metabolism-related lack of efficacy. >>It has been shown that variability in drug metabolism can have a substantial effect on clinical outcomes in patients. The impact of such variability in inter-individual responsiveness to the same dose of a given drug has historically received considerable attention. Drug metabolism is affected by numerous factors of both environmental and genetic origin. Recently, increased attention has been given to the genetic factors that may affect drug … Continue reading

Posted in epigenetics, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News | Tagged , , | Comments Off on Metabolic Fate of Pharmaceuticals: A Focus on Slow Metabolizers

Simvastatin impairs exercise training adaptations.

Simvastatin impairs exercise training adaptations. Mikus CR, et al. Show all J Am Coll Cardiol. 2013 Aug 20;62(8):709-14. doi: 10.1016/j.jacc.2013.02.074. Epub 2013 Apr 10. Affiliation Division of Cardiology, Duke University Medical Center, Durham, North Carolina. Abstract OBJECTIVES: This study sought to determine if simvastatin impairs exercise training adaptations. BACKGROUND: Statins are commonly prescribed in combination with therapeutic lifestyle changes, including exercise, to reduce cardiovascular disease risk in patients with metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired mitochondrial function, but … Continue reading

Posted in Complementary - Alternative Medicine, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, metabolic | Tagged , | Comments Off on Simvastatin impairs exercise training adaptations.

Long-term use of statins may be associated with increased risks of both ductal and lobular breast cancer among women 55-74 years of age

Search Home PDF Current Issue Past Issues OnlineFirst Long-term statin use and risk of ductal and lobular breast cancer among women 55-74 years of age  Authors Abstract Background: Mechanistic studies largely support the chemopreventive potential of statins. However, results of epidemiologic studies investigating statin use and breast cancer risk have been inconsistent and lacked the ability to evaluate long-term statin use. Methods: We utilized data from a population-based case-control study of breast cancer conducted in the Seattle-Puget Sound region to investigate the relationship between long-term … Continue reading

Posted in Aging, Complementary - Alternative Medicine, dietary, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, News | Tagged , | Comments Off on Long-term use of statins may be associated with increased risks of both ductal and lobular breast cancer among women 55-74 years of age