Tag Archives: Pain and Headache

Preter Klein Panic disorder theory now available on PubMed Central (PMC)

[nihms] Manuscript #585187: Your manuscript is available in PMC Dear Maurice Preter, Manuscript NIHMS585187 (“Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder”) has been loaded into PubMed Central (PMC) and made available for public access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195810 The submission process for this manuscript is now complete. We encourage you to make further manuscript submissions as they become eligible. As always, please feel free to contact the NIHMS Help Desk with any questions at http://www.nihms.nih.gov/db/sub.cgi?page=email. Thank you … Continue reading

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Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions

Important paper on childhood adversities an adult-age chronic medical conditions, published just before our study on endogenous opioid dysregulation after early childhood adversity in psychiatrically and physically “healthy” adults.   Archives of General Psychiatry August 2011, Vol 68, No. 8 > < Previous ArticleNext Article > Original Article | Aug 2011 Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions Kate M. Scott, PhD; Michael Von Korff, ScD; Matthias C. Angermeyer, MD, PhD; Corina Benjet, PhD; Ronny Bruffaerts, PhD; Giovanni de Girolamo, MD; Josep Maria Haro, MD, MPH, … Continue reading

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Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life

Meta-Analyses: Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life. Another gem from Dr. Ken Pope’s web site.    

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Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds

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Invitation to my Grand Rounds Talk at Mount Sinai, Wednesday, October 9, 2013, 8am

Please join us for our next Neurology Grand Rounds on Wednesday, October 9th at 8 AM in Davis Auditorium (Hess Center for Science and Medicine) at 1470 Madison Ave between 101st and 102nd streets. Refreshments will be served at 7:30 AM so please feel free to arrive early.

Title: “Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology?”

Presenter: Dr. Maurice Preter, MD
Assistant Professor of Clinical Psychiatry,
Columbia’s College of Physicians and Surgeons;
Associate Professor of Neurology (Adj.),
SUNY Downstate Medical Center, Brooklyn, NY
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Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American

Flatworms Recall Familiar Environs, Even after Losing Their Heads: Scientific American. Highly recommended reading. As it turns out, one does not have to go all the way down the evolutionary ladder to be reminded that even brain-impaired or brain-damaged individuals (whether through TBI, dementia, various levels of unconsciousness, or simply sleep) have not only memories, but continue to experience emotions, good and bad. As an illustration that the brain is made of many different levels and parts, here is a recent paper by Feinstein et … Continue reading

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NBA Releases Summary of its Concussion Policy

By Brett Pollakoff May 18, 2013, 9:30 AM EDT from www.nbcsports.com The NBA has had a concussion policy in place for the past 18 months, and while all teams have been made aware of the details, they haven’t been publicly available until now. With the recent concussion that kept George Hillout of the Pacers’ Game 5 loss to the Knicks (and may sideline him even longer), Mike Wells of theIndianapolis Star requested the policy from the league, and he was provided with a summary. You can read the entire thing for yourself below, … Continue reading

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North Shore-Lenox Hill Hospital Neurology Grand Rounds on May 21, 2013 Topic: Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: How panic research can inform clinical neurology.

I will be giving North Shore-Lenox Hill Hospital Neurology Grand Rounds on May 21, 2013 – all invited! Topic:    Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: How panic research can inform clinical neurology.  Speaker:  Maurice Preter, MD Date:          5/21/2013 Time:    8:30-9:30 AM                  Location:  2nd Floor Achelis Conference Room [PDF is here: North Shore flyer may 21] Learning Objectives: Upon completion of this session, participants should be able to: 1) Understand research on panic and separation anxiety 2) Be able to apply … Continue reading

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Neuroprotective properties of magnesium infusion during carotid endarterectomy, and beyond?

Went to a masterful talk by E. Sander Connolly at the Lenox Hill Hospital neurology conference last week. This is one of many interesting take-away points. Differential blood-brain barrier penetration by the various statins is another one – currently looking into how this impacts clinical decision making. MP J Neurosurg. Author manuscript; available in PMC 2009 July 1. Published in final edited form as: J Neurosurg. 2009 May; 110(5): 961–967. doi:  10.3171/2008.9.17671 PMCID: PMC2684565 NIHMSID: NIHMS101036 Intraoperative magnesium infusion during carotid endarterectomy: a double-blind placebo-controlled … Continue reading

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The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy.

Front Neurosci. 2012;6:33. doi: 10.3389/fnins.2012.00033. Epub 2012 Mar 26. The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy. Ruskin DN, Masino SA. Source Neuroscience Program, Department of Psychology, Trinity College Hartford, CT, USA. Abstract A link between metabolism and brain function is clear. Since ancient times, epileptic seizures were noted as treatable with fasting, and historical observations of the therapeutic benefits of fasting on epilepsy were confirmed nearly 100 years ago. Shortly thereafter a high fat, low-carbohydrate ketogenic diet (KD) debuted as … Continue reading

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Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.

PLoS One. 2009 Dec 23;4(12):e8349. doi: 10.1371/journal.pone.0008349. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. Ruskin DN, Kawamura M, Masino SA. Source Department of Psychology and Neuroscience Program, Trinity College, Hartford, Connecticut, United States of America. Abstract The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes, and recent basic research provides evidence that ketogenic strategies … Continue reading

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