Tag Archives: Parkinson disease

Dementia and Alzheimers’ Disease – How Can It Be Treated?

Dementia and Alzheimers’ Disease – How Can It Be Treated?

The Latin word “De-mentia”, literally means, the removal of a person from their own mind. It stands for a significant decrease in brain function, including memory, goal-directed thinking, orientation in space and time, and language ability.

Most dementias are progressive. They cannot be cured and will gradually cause more severe problems for the patient, and for the patient’s caretakers. As the population ages, Alzheimer’s disease is on its way to becoming the third most common fatal disease.

Prescription medications on the market starting in the 1990s to treat dementia have been a disappointment to patients and doctors alike.

The frustration caused by this situation prompted me to make the development of an anti-dementia treatment protocol a major focus of my clinical work.

As always, we start with a thorough neuropsychiatric assessment, looking for potentially reversible causes of cognitive decline such as a thyroid condition, vitamin deficiency, a sleep disorder, elevated blood sugar and diabetes. Importantly, untreated depression and chronic high stress and anxiety levels are associated with a higher risk for dementia. Most of the time, psychotherapy is a far better alternative to the all-too-common multiple prescription drugs.

The protocol uses a number of carefully evaluated novel interventions and components based on sound neuroscientific principles, sourced from both functional medicine and traditional medical systems, such as Ayurvedic and traditional Chinese medicine.

The protocol stabilizes many of my patients, and improves their functioning and quality of life. It has shown promising results not only for dementia, but also for traumatic brain injury. Continue reading

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Update on the treatment of Alzheimer’s Disease – from the International Conference of Parkinson Disease & Movement Disorders/MDS Developing World Education Program (DWEP). Shanghai First People’s Hospital, Jiao Tong University, Shanghai, PRC. September 30, 2016

Update on the treatment of Alzheimer’s Disease – from the International Conference of Parkinson Disease & Movement Disorders/MDS Developing World Education Program (DWEP). Shanghai First People’s Hospital, Jiao Tong University, Shanghai, PRC. September 30, 2016 Continue reading

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Milk consumption and the risk of nigral degeneration

Milk consumption and the risk of nigral degeneration http://tinyurl.com/jomtju6 Honglei Chen, MD, PhD and Karen Marder, MD, MPH +SHOW AFFILIATIONS | + SHOW FULL DISCLOSURES Correspondence to Dr. Chen: chenh2@niehs.nih.gov Published online before print December 9, 2015, doi: http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000002268 Neurology February 9, 2016 vol. 86 no. 6 496-497 In the era of genetic research for neurodegenerative diseases, less attention has been paid to epidemiologists’ search for potential environmental risk factors for Parkinson disease (PD). Epidemiologic evidence suggests that cigarette smoking is associated with about 50% lower risk … Continue reading

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Midlife milk consumption and substantia nigra neuron density at death

Midlife milk consumption and substantia nigra neuron density at death http://tinyurl.com/jjwookb Robert D. Abbott, PhD, G. Webster Ross, MD, Helen Petrovitch, MD, Kamal H. Masaki, MD, Lenore J. Launer, PhD, James S. Nelson, MD, Lon R. White, MD and Caroline M. Tanner, MD, PhD +SHOW AFFILIATIONS | + SHOW FULL DISCLOSURES Correspondence to Dr. Abbott: rda3e@virginia.edu Published online before print December 9, 2015, doi: http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000002254 Neurology February 9, 2016 vol. 86 no. 6 512-519 ABSTRACT Objective: To examine the relationship between midlife milk intake and Parkinson disease (PD) incidence through associations with substantia … Continue reading

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Accuracy of clinical diagnosis of Parkinson disease

Accuracy of clinical diagnosis of Parkinson disease http://tinyurl.com/jq9aakn A systematic review and meta-analysis Giovanni Rizzo, MD, Massimiliano Copetti, PhD, Simona Arcuti, PhD, Davide Martino, MD, Andrea Fontana, MScand Giancarlo Logroscino, MD +SHOW AFFILIATIONS + SHOW FULL DISCLOSURES Correspondence to Dr. Logroscino: giancarlo.logroscino@uniba.it Published online before print January 13, 2016, doi: http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000002350  Neurology February 9, 2016 vol. 86 no. 6 566-576 ABSTRACT Objective: To evaluate the diagnostic accuracy of clinical diagnosis of Parkinson disease (PD) reported in the last 25 years by a systematic review and meta-analysis. Methods: We searched for articles … Continue reading

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Neuroprotective and disease-modifying effects of the ketogenic diet

Behav Pharmacol. 2006 Sep; 17(5-6): 431–439.  PMCID: PMC2367001 NIHMSID: NIHMS42857 Neuroprotective and disease-modifying effects of the ketogenic diet Maciej Gasior,a Michael A. Rogawski,a and  Adam L. Hartmana,b Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Behav Pharmacol See other articles in PMC that cite the published article. Go to: Abstract The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the ketogenic diet may confer … Continue reading

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Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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Time to confront the global dementia crisis : The Lancet Neurology

Time to confront the global dementia crisis The Lancet Neurology High-income countries are not the only ones facing a dementia crisis as their populations age. According to the Alzheimer’s Disease International (ADI) Delphi consensus study, by 2040, 71% of all people with dementia will be living in developing countries. In addition to the personal devastation for these 58 million people and their families, the economic burden is likely to be immense: in this issue of The Lancet Neurology, Kalaria and colleagues estimate that the total … Continue reading

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Pycnogenol – PubMed – NCBI

Massive increase in number of publications on pycnogenol over the past couple of years, with mixed results so far. It seems to help with jet lag. Worth keeping an eye on.   Am J Epidemiol. 2012 Nov 8. [Epub ahead of print] Association Between Use of Specialty Dietary Supplements and C-Reactive Protein Concentrations. Kantor ED, Lampe JW, Vaughan TL, Peters U, Rehm CD, White E. Abstract Laboratory evidence suggests that certain specialty dietary supplements have antiinflammatory properties, though evidence in humans remains limited. Data on … Continue reading

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Football players’ mortality from Alzheimer disease and Lou Gehrig’s is 4 times higher

Another dent in the tired old tale of the role of (Mendelian) heredity in neuropsychiatry. More good stuff published in Neurology this week to follow. Articles Neurodegenerative causes of death among retired National Football League players Everett J. Lehman, MS, Misty J. Hein, PhD, Sherry L. Baron, MD and Christine M. Gersic + Author Affiliations From the Centers for Disease Control and Prevention, The National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, OH. Correspondence & reprint requests … Continue reading

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Inflammation is the common link among the leading causes of death.

Psychosom Med. 2010 May;724:365-9. Epub 2010 Apr 21. Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge. Kiecolt-Glaser JK. Department of Psychiatry, The Ohio State Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, Ohio 43210-1228, USA. Janice.Kiecolt-Glaser@osumc.edu Abstract Inflammation is the common link among the leading causes of death. Mechanistic studies have shown how various dietary components can modulate key pathways to inflammation, including sympathetic activity, oxidative stress, transcription factor nuclear factor-kappaB activation, and proinflammatory cytokine production. Behavioral … Continue reading

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Chronic anxiety and Parkinson disease risk

Psychological trauma and early life stress probably too. Chronic mild stress induces anxiety-like behavior and down-regulation of dopamine system activity in rats via OASIS.

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