Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later

Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later

http://tinyurl.com/zzlgg8k

Nicole L. Spartano, PhDJayandra J. Himali, PhDAlexa S. Beiser, PhDGregory D. Lewis, MDCharles DeCarli, MDRamachandran S. Vasan, MD and Sudha Seshadri, MD

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Correspondence to Dr. Spartano: spartano@bu.edu

Neurology 10.1212/WNL.0000000000002415

ABSTRACT

Objective: To determine whether poor cardiovascular (CV) fitness and exaggerated exercise blood pressure (BP) and heart rate (HR) were associated with worse brain morphology in later life.

Methods: Framingham Offspring participants (n = 1,094, 53.9% female) free from dementia and CV disease (CVD) underwent an exercise treadmill test at a mean age of 40 ± 9 years. A second treadmill test and MRI scans of the brain were administered 2 decades later at mean age of 58 ± 8 years.

Results: Poor CV fitness and greater diastolic BP and HR response to exercise at baseline were associated with a smaller total cerebral brain volume (TCBV) almost 2 decades later (all p < 0.05) in multivariable adjusted models; the effect of 1 SD lower fitness was equivalent to approximately 1 additional year of brain aging in individuals free of CVD. In participants with prehypertension or hypertension at baseline, exercise systolic BP was also associated with smaller TCBV (p < 0.05).

Conclusion: Our results suggest that lower CV fitness and exaggerated exercise BP and HR responses in middle-aged adults are associated with smaller brain volume nearly 2 decades later. Promotion of midlife CV fitness may be an important step towards ensuring healthy brain aging.

Received August 11, 2015.

Accepted in final form December 14, 2015.

Maurice Preter, MD

About Maurice Preter MD

Maurice Preter, MD is a European and U.S. educated psychiatrist, psychotherapist, psychopharmacologist, neurologist, and medical-legal expert in private practice in Manhattan. He is also the principal of Fifth Avenue Concierge Medicine, PLLC, a medical concierge service and health advisory for select individuals and families.
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