| Diabetes Care. 2007 Mar;30(3):716-8. | Related Articles, Links |
Yeh SH, Chuang H, Lin LW, Hsiao CY, Wang PW, Yang KD.
Department of Nursing, Chang Gung Institute of Technology, Kwei-Shan, Taoyuan, Taiwan.
Publication Types:
PMID: 17327347 [PubMed – indexed for MEDLINE]
Institute of Psychiatry and Guy’s, King’s and St Thomas’s School of Medicine, De Crespigny Park, London SE5 8AF. p.fearon@iop.kcl.ac.uk
OBJECTIVE: To elucidate the associations between frequent headache and psychosocial factors in childhood and to determine whether such children are at an increased risk of headache, multiple physical symptoms, and psychiatric symptoms in adulthood. DESIGN: Population based birth cohort study. SETTING: General population. PARTICIPANTS: People participating in the national child development study, a population based birth cohort study established in 1958. Main outcome measures: Headache, multiple physical symptoms, and psychiatric morbidity at age 33. RESULTS: Headache in childhood was associated with several psychosocial factors. Prospectively, children with frequent headache had an increased risk in adulthood of headache (odds ratio 2.22, 95% confidence interval 1.62 to 3.06), multiple physical symptoms (1.75, 1.46 to 2.10), and psychiatric morbidity (1.41, 1.20 to 1.66). The outcomes of headache and multiple physical symptoms were not accounted for by psychiatric morbidity. CONCLUSION: Children with headache are at an increased risk of recurring headache in adulthood and may complain of other physical and psychiatric symptoms. Strategies for coping with psychosocial adversity in childhood may improve the prognosis in adulthood.
PMID: 11348907 [PubMed – indexed for MEDLINE]
| J Paediatr Child Health. 2007 Apr;43(4):262-70. | Related Articles, Links |
Evans S, Keenan TR, Shipton EA.
Department of Health and Social Care, University of Canterbury, New Zealand.
Aim: There is limited research examining the functioning of children living with parental chronic pain and illness. The aim of this study was to examine the psychosocial adjustment and physical health of children living with a mother experiencing chronic pain. Methods: One-hundred and three children aged 6-12 years served as participants, with approximately equal numbers of children in maternal chronic pain (n = 55) and control groups (n = 48). Children completed self-reports about their internalising behaviour, health and attachment security. Mothers, fathers and teachers completed questionnaires relating to children’s internalising and externalising behaviour, social behaviour and physical health. Results: Reports from children, mothers and fathers indicated significantly more internalising, externalising, insecure attachment and social and health problems for children in the maternal chronic pain group compared with control children. Teachers reported decreased social skills and increased pain complaints for children in the maternal chronic pain group. Boys in the maternal chronic pain group appear to be affected more than girls. Boys reported more anxiety and insecure attachment, while mothers reported greater social problems and increased illness behaviour for boys. Characteristics of the mother’s pain condition, such as, severity, length and frequency were generally unrelated to child functioning. Conclusions: The study demonstrates the importance of maternal and family variables to child outcomes. The results are discussed in terms of maternal chronic pain comprising a considerable, yet rarely studied, influence in the lives of young children.
PMID: 17444828 [PubMed – in process]
| Neurol Clin. 2007 May;25(2):507-22. | Related Articles, Links |
Krishnaney AA, Park J, Benzel EC.
Cleveland Clinic Center for Spine Health and Department of Neurosurgery, Cleveland Clinic Neurological Institute, Cleveland Clinic, 9500 Euclid Ave., S-80, Cleveland, OH 44195-001, USA.
Surgical intervention for neck pain and low back pain may be of benefit to some patients. It should be considered, however, only in cases where medical management has failed and there is a clearly identifiable anatomic lesion that likely is the pain generator. Indications, preoperative evaluation, and common surgical procedures are reviewed.
Environmental impact actually important.
Nature Reviews Neuroscience 8, 355-367 (May 2007) | doi:10.1038/nrn2132
Nadia Tsankova1, William Renthal1, Arvind Kumar1 & Eric J. Nestler1 About the authors
Many neurological and most psychiatric disorders are not due to mutations in a single gene; rather, they involve molecular disturbances entailing multiple genes and signals that control their expression. Recent research has demonstrated that complex ‘epigenetic’ mechanisms, which regulate gene activity without altering the DNA code, have long-lasting effects within mature neurons. This review summarizes recent evidence for the existence of sustained epigenetic mechanisms of gene regulation in neurons that have been implicated in the regulation of complex behaviour, including abnormalities in several psychiatric disorders such as depression, drug addiction and schizophrenia.
Maurice Preter, MD is a European and U.S. educated psychiatrist, psychotherapist, psychopharmacologist, neurologist, and medical-legal expert in private practice in Manhattan. He is also the principal of Fifth Avenue Concierge Medicine, PLLC, a medical concierge service and health advisory for select individuals and families.
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