Tea drinking and cognitive function in oldest-old Chinese.

J Nutr Health Aging. 2012;16(9):754-8. doi: 10.1007/s12603-012-0077-1.

Tea drinking and cognitive function in oldest-old Chinese.

Source

Department of Psychological Medicine, National University of Singapore. pcmfl@nus.edu.sg

Abstract

OBJECTIVE:

We examined the longitudinal association between tea drinking frequency and cognitive function in a large sample of oldest-old Chinese.

DESIGN:

population-based longitudinal cohort study.

SETTING:

The Chinese Longitudinal Healthy Longevity Survey (CLHLS).

PARTICIPANTS:

7139 participants aged 80 to 115 (mean age 91.4 years) who provided complete data at baseline (year 1998).

MEASUREMENTS:

Current frequency of tea drinking and past frequency at age 60 were ascertained at baseline, and baseline and follow-up cognitive assessments were performed in the years 1998 (n=7139), 2000 (n=4081), 2002 (n=2288) and 2005 (n=913) respectively. Verbal fluency test was used as measure of cognitive function.

RESULTS:

Tea drinking was associated at baseline with higher mean (SD) verbal fluency scores: daily=10.7 (6.6), occasional=9.2 (5.8), non-drinker=9.0 (5.5). In linear mixed effects model that adjusted for age, gender, years of schooling, physical exercise and activities score, the regression coefficient for daily drinking (at age 60) and occasional drinking was 0.72 (P<0.0001) and 0.41(P=0.01) respectively. Tea drinkers had higher verbal fluency scores throughout the follow-up period but concurrently had a steeper slope of cognitive decline as compared with non-drinkers (coefficient for the interaction term Time*Daily drinking= -0.12, P=0.02; “Time” was defined as the time interval from baseline to follow-up assessments in years). Similar results were found for current tea drinking status at study baseline year (1998) as predictor variable.

CONCLUSION:

Regular tea drinking is associated with better cognitive function in oldest-old Chinese.

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Life event stress and chronic obstructive pulmonary disease (COPD)

BMJ Open. 2012 Nov 19;2(6). pii: e001674. doi: 10.1136/bmjopen-2012-001674. Print 2012.

Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study.

Source

Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Abstract

OBJECTIVES:

To investigate whether life event stress was associated with greater psychological distress and poorer quality of life in older individuals with chronic obstructive pulmonary disease (COPD), in comparison with their counterparts without COPD.

DESIGN:

Cross-sectional study.

PARTICIPANTS:

A population-based sample (N=497) of individuals aged 65 and above with COPD (postbronchodilatation FEV1/FVC<0.70, N=136) and without COPD (N=277).

MEASUREMENTS:

We measured life event stress, depressive symptoms (GDS, Geriatric Depression Scale), cognitive symptoms and function (CFQ, Cognitive Failures Questionnaire and MMSE, Mini-Mental State Examination), and physical and mental health functional status (SF36-PCS, Physical Health Component Summary and SF36-MCS, Mental Health Component Summary) in participants with and without COPD.

RESULTS:

In two-way analysis of variance controlling for potential confounders, life event stress was associated with significant main effects of worse GDS (p<0.001), SF36-PCS (p=0.008) and SF36-MCS scores (p<0.001), and with significant interaction effects on GDS score (p<0.001), SF36-PCS (p=0.045) and SF36-MCS (p=0.034) in participants with COPD, more than in non-COPD participants. The main effect of COPD was found for postbronchodilator FEV1 (p<0.001) and cognitive symptoms (p=0.02).

CONCLUSIONS:

Our findings indicate that life event stress was associated with more depressive symptoms and worse quality of life in individuals with COPD, much more than in those without COPD. Further studies should explore the role of cognitive appraisal of stress, coping resources and psycho-social support in this relationship.

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Allen Frances on Bloomberg.com: How Many Billions a Year Will the DSM-5 Cost?

How Many Billions a Year Will the DSM-5 Cost?

By Allen Frances Dec 20, 2012 6:30 PM ET

In preparing the DSM-5, the revised manual that is to be the next bible of psychiatric diagnosis, the American Psychiatric Association has been extravagantly indifferent to all matters of cost.

There are profound economic consequences to where boundaries are set between what is normal and what is considered a mental disorder. Diagnosis of mental illness brings on a cascade of costs, including doctor visits, tests, medications (and treatment for their complications), forensic and prison costs, disability obligations, the siphoning of educational resources and absenteeism.

We are already experiencing an inflation in psychiatric diagnosis and an explosion in the use of expensive, and often unnecessary and harmful, psychotropic drugs.

Now, the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders will add new categories of mental illness with very high prevalence rates in the general population. A new diagnosis here, a new diagnosis there, and pretty soon you have millions of new patients and billions of dollars in expenditure.

Seemingly small DSM-5 changes will make a big difference. Normal grief will become “major depressive disorder,” so that pills and medical rituals will be applied to a person’s natural emotional reaction to the loss of a loved one.

Excessive eating a dozen times in three months will become not mere gluttony but “binge eating disorder.” Forgetfulness in old age will be “minor neurocognitive disorder,” a label encompassing an enormous new patient population (only some of whom are at real risk of dementia) and incurring huge costs of unnecessary brain imaging when there is no effective treatment.

New ‘Patients’

At the other end of the age continuum, temper tantrums will be diagnosed as “disruptive mood dysregulation disorder.” And these are but a few of the many changes in the DSM-5 that will create millions of new “patients,” many of whom would do better without expensive, potentially harmful treatments.

The new manual will also encourage doctors to misdiagnose physical disorders as mental ones by creating a broad new category for patients who are anxious about their medical symptoms.

No one has calculated the total direct and indirect monetary costs of the DSM-5 to the U.S. economy, but the drain threatens to be enormous. And the extra money will probably be spent in the wrong places.

Our scarce mental-health resources are already distributed in an irrational manner. We badly shortchange those with clear psychiatric disorders while overtreating essentially normal people. Many psychiatric patients wind up filling our overcrowded prisons at an annual cost per capita greater than a year at Princeton University.

By further reducing the “normal” pool, the DSM-5 will divert even more resources away from those most in need of help.

How will DSM-5 raise costs?

First there are the direct and indirect costs of treating the newly diagnosed patients. These will be further amplified by the extension of health insurance under the Affordable Care Act to some 34 million more Americans, and its requirement that insurance include comprehensive care for mental disorders.

This is a desirable policy change; a greater investment is certainly needed to shore up our badly shortchanged mental- health system. But the costs should be predictable and the money spent where it is likely to do the most good.

Then there are indirect medical costs of treating complications from excessive medication use. Antipsychotics frequently cause enormous weight gain that can lead to diabetes and heart disease. Overdoses with prescription drugs now cause more visits to emergency rooms and expensive hospitalizations than overdoses with street drugs.

Disability payments, workers compensation and veterans benefits spent on psychiatric care will also rise. And the newly diagnosed will, of course, incur increased sick days, resulting in a loss of productivity.

Inadequate Reviews

The new DSM-5 diagnoses can be as dangerous as new drugs, but have not received the same kind of thorough risk-benefit review the U.S. Food and Drug Administration provides before approving a new medicine. And they have received no cost-benefit review.

Having been extremely profligate in its own expenditures — the DSM-5 has already cost $25 million, five times as much as the DSM-IV in 1994 — the association has taken no account of the potential costs to the public from its clinically risky diagnostic changes.

It is now desperately dependent on DSM’s perennial best- seller status to balance its books and is prematurely racing the new manual to press — treating it as a publishing cash cow, not the public trust it should be.

We need a broader national dialogue on mental health, its costs, and how best to spend precious resources. The DSM-5 is a giant step in the wrong direction — away from good clinical common sense and fiscal responsibility.

Clinicians and patients have a big stake in pushing back, and so do government and industry. The only sector that stands to benefit from the DSM-5 is the pharmaceutical business. The rest of us will pay the price.

(Allen Frances, a psychiatrist and professor emeritus at Duke University School of Medicine, was the chairman of the task force that produced the DSM-IV. The opinions expressed are his own.)

To contact the writer of this article: Allen Frances at allenfrances@vzw.blackberry.net.

To contact the editor responsible for this article: Mary Duenwald at mduenwald@bloomberg.net.

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Finasteride induced depression: a prospective study.

Finasteride induced depression: a prospective study.

Rahimi-Ardabili BPourandarjani RHabibollahi PMualeki A.

Source

Clinical Pharmacy Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ba.rahimi@gmail.com

Abstract

BACKGROUND:

Finasteride is a competitive inhibitor of 5 alpha-reductase enzyme, and is used for treatment of benign prostatic hyperplasia and androgenetic alopecia. Animal studies have shown that finasteride might induce behavioral changes. Additionally, some cases of finasteride-induceddepression have been reported in humans. The purpose of this study was to examine whether depressive symptoms or anxiety might be induced byfinasteride administration.

METHODS:

One hundred and twenty eight men with androgenetic alopecia, who were prescribed finasteride (1 mg/day) were enrolled in this study. Information on depressed mood and anxiety was obtained by Beck Depression Inventory (BDI), and Hospital Anxiety and Depression Scale (HADS). Participants completed BDI and HADS questionnaires before beginning the treatment and also two months after it.

RESULTS:

Mean age of the subjects was 25.8(+/- 4.4) years. At baseline, mean BDI and HADS depression scores were 12.11(+/- 7.50) and 4.04(+/- 2.51), respectively. Finasteride treatment increased both BDI (p < 0.001) and HADS depression scores significantly (p = 0.005). HADS anxiety scores were increased, but the difference was not significant (p = 0.061).

CONCLUSION:

This preliminary study suggests that finasteride might induce depressive symptoms; therefore this medication should be prescribed cautiously for patients with high risk of depression. It seems that further studies would be necessary to determine behavioral effects of this medication in higher doses and in more susceptible patients.

 

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Finasteride treatment influences neuronal plasticity on a structural level. These changes might contribute to the pathophysiology of depressive episodes observed after finasteride treatment.

Pharmacopsychiatry. 2010 Jul;43(5):174-8. doi: 10.1055/s-0030-1249095. Epub 2010 May 18.

Finasteride treatment inhibits adult hippocampal neurogenesis in male mice.

Römer BPfeiffer NLewicka SBen-Abdallah NVogt MADeuschle MVollmayr BGass P.

Source

RG Behavioural Biology, Central Institute of Mental Health, Mannheim, University of Heidelberg, Germany. benedikt.roemer@zi-mannheim.de

Abstract

INTRODUCTION:

The 5-alpha-reductase inhibitor finasteride is used for the treatment of androgenic alopecia, benign prostate hyperplasia and prostate cancer. Besides inhibiting the conversion of testosterone to the biologically more active 5alpha-dihydrotestosterone, it also inhibits the production of neurosteroids. Decreased neurosteroid levels are postulated to be involved in the pathophysiology of psychiatric disorders such as depression. As neurosteroids metabolized by 5-alpha-reductase influence neural plasticity, we investigated whether finasteride treatment alters adult hippocampal neurogenesis, implicated in the pathophysiology of depression.

METHODS:

Male C57BL/6N mice were treated subchronically (7 days) with finasteride or vehicle. Adult neurogenesis was assessed at two different time points after treatment (day 1; day 35) using immunohistochemistry.

RESULTS:

Finasteride treatment led to a significant decrease in brain 5alpha-dihydrotestosterone levels and induced a reversible reduction in the number of newborn cells and young neurons in the hippocampus. 35 days after the last finasteride injection, neurogenesis had returned to normal.

DISCUSSION:

These data indicate that inhibition of 5-alpha-reductase activity by finasteride treatment influences neuronal plasticity on a structural level. These changes might contribute to the pathophysiology of depressive episodes observed after finasteride treatment.

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