Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

Posted on November 25, 2012 by Maurice Preter MD

J Ethnopharmacol. 2010 Oct 28;132(1):200-5. Epub 2010 Aug 14.

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats.

Esmaeili-Mahani S, Rezaeezadeh-Roukerd M, Esmaeilpour K, Abbasnejad M, Rasoulian B, Sheibani V, Kaeidi A, Hajializadeh Z.

Source

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran. semahani@yahoo.com

Abstract

AIM OF THE STUDY:

Olive (Olea europaea) leaves are used as anti-rheumatic, anti-inflammatory, antinociceptive, antipyretic, vasodilatory, hypotensive, antidiuretic and hypoglycemic agents in traditional medicine. Recently, it has been shown that olive leaf extract (OLE) has calcium channel blocker property; however, its influences on nociceptive threshold and morphine effects have not yet been clarified.

MATERIALS AND METHODS:

All experiments were carried out on male Wistar rats. The tail-flick, hot-plate and formalin tests were used to assess the effect of OLE on nociceptive threshold. To determine the effect of OLE on analgesic and hyperalgesic effects of morphine, OLE (6, 12 and 25 mg/kg i.p.) that had no significant nociceptive effect, was injected concomitant with morphine (5 mg/kg and 1 μg/kg i.p., respectively). The tail-flick test was used to assess the effect of OLE on anti- and pro-nociceptive effects of morphine.

RESULTS:

The data showed that OLE (50-200 mg/kg i.p.) could produce dose-dependent analgesic effect on tail-flick and hot-plate tests. Administration of 200 mg/kg OLE (i.p.) caused significant decrease in pain responses in the first and the second phases of formalin test. In addition, OLE could potentiate the antinociceptive effect of 5 mg/kg morphine and block low-dose morphine-induced hyperalgesia.

CONCLUSION:

Our results indicate that olive leaf extract has analgesic property in several models of pain and useful influence on morphine analgesia in rats. Therefore, it can be used for the treatment and/or management of painful conditions.

Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

via Olive (Olea europaea L.) leaf extract elici… [J Ethnopharmacol. 2010] – PubMed – NCBI.

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Daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.

Posted on November 25, 2012 by Maurice Preter MD

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1878-82. Epub 2012 Jan 23.

Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.

Chiang JJ, Eisenberger NI, Seeman TE, Taylor SE.

Source

Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Abstract

Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNFαRII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNFαRII at baseline, and IL-6 and sTNFαRII 25-min poststressor, as well as total output of sTNFαRII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNFαRII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.

PMID:

22308464

[PubMed – indexed for MEDLINE]

PMCID:

PMC3277534

Free PMC Article

via 18 selected items – PubMed – NCBI.

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Social pain–the painful feelings associated with social disconnection–rely on some of the same neurobiological substrates that underlie experiences of physical pain

Posted on November 25, 2012 by Maurice Preter MD

Nat Rev Neurosci. 2012 May 3;13(6):421-34. doi: 10.1038/nrn3231.

The pain of social disconnection: examining the shared neural underpinnings of physical and social pain.

Eisenberger NI.

Source

University of California, Department of Psychology, 4444 Franz Hall, Los Angeles, California 90095, USA. neisenbe@ucla.edu

Abstract

Experiences of social rejection, exclusion or loss are generally considered to be some of the most ‘painful’ experiences that we endure. Indeed, many of us go to great lengths to avoid situations that may engender these experiences (such as public speaking). Why is it that these negative social experiences have such a profound effect on our emotional well-being? Emerging evidence suggests that experiences of social pain–the painful feelings associated with social disconnection–rely on some of the same neurobiological substrates that underlie experiences of physical pain. Understanding the ways in which physical and social pain overlap may provide new insights into the surprising relationship between these two types of experiences.

PMID:

22551663

[PubMed – indexed for MEDLINE]

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An endogenous opioid deficiency/expanded suffocation false alarm theory model of panic disorder.

Posted on November 24, 2012 by Maurice Preter MD

These are the slides from my  talk at the First International Symposium on Translational Models of Panic Disorder. Vitoria, ES, Brazil, November 16-18, 2012.

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Michael Holick MD’s Vitamin D lecture – essential viewing

Posted on November 21, 2012 by Maurice Preter MD

Posted in Aging, China, development, dietary, epigenetics, Fifth Avenue Concierge Medicine, Forensic Neuropsychiatry, Health, keto, metabolic, Psychiatry/Neurology | Tagged , , , , , , , |