Effects of seasonal mood changes on seasonal variations in coronary heart disease: role of immune system, infection, and inflammation.

Nice piece by Leo Sher from before the Vitamin D connection was on everyone’s mind.

Med Hypotheses. 2001 Jan;56(1):104-6.
Effects of seasonal mood changes on seasonal variations in coronary heart disease: role of immune system, infection, and inflammation.
Sher L.
Abstract

Coronary heart disease shows a winter peak and summer trough in incidence and mortality. A substantial part of a general population experiences seasonal mood changes including winter depression. Many studies demonstrate that depression is associated with increased incidence, morbidity, and mortality of cardiovascular disease. Therefore, the author previously suggested that persons with high levels of seasonality may be at increased risk of developing or worsening of coronary heart disease in the winter. Some psychological factors promote the development of disorders of the cardiovascular system. The same psychological factors decrease immunity and promote infection. There is evidence that the infectious process is involved in the pathogenesis of coronary heart disease. Therefore, the author previously proposed that the development of infection and inflammation in the atherosclerotic plaque may be related to the psychological disorders that suppress the immune system. In this paper, the author suggests that winter depression-induced suppression of the immune system may contribute to the winter increase in incidence and mortality of cardiovascular disease.

PMID:
11133264
[PubMed – indexed for MEDLINE]

Posted in Uncategorized | Tagged |

Quality psychiatric care is needed

Quality psychiatric care is needed

China Daily article mirrored on Xinhua

Posted in Psychiatry/Neurology |

China Daily Op-ed: Quality psychiatric care is needed – not only in China

Cross-posted from Chinadaily.com July 5, 2010:

http://www.chinadaily.com.cn/opinion/2010-07/05/content_10056660.htm

Quality psychiatric care is needed
Op-Ed By Dr. Maurice Preter (China Daily)
Updated: 2010-07-05 08:00

The recent spate of attacks on schoolchildren and the workers’ suicides at the Foxconn factory in Shenzhen have again highlighted China’s urgent need to balance economic progress with care for those left behind, and unable to cope with, the lightning speed of development.

Sustainable development is an avowed goal of Chinese government policy, and from a medical-psychological perspective, accessible, quality general medical and psychiatric care is a fundamental part of long-term, ecologically minded, peaceful societal progress.

However, it is an open secret that the medical profession in China is in disarray and rather ill-equipped to contribute to the solution of China’s larger societal problems. Chinese physicians are overworked. They routinely see several dozen, if not a hundred patients a day, including those in urgent need of expert mental health treatment.

They are forced to accept absurdly low salaries and are consequently, generally disrespected. Pharmaceutical sales productivity incentives imposed by hospital administrations and by the wish to supplement meager earnings lead to a medical assembly line mentality that short-changes patients and frustrates doctors.

It comes as no surprise that, according to data cited in this newspaper (China Daily, March 25, 2010: “Doctors at receiving end in medical reform”), there are high levels of stress and depression among Chinese doctors.

Coincidentally or not, this year’s most murderous school attack was perpetrated by a supposedly mentally ill physician.

This situation is unlikely to attract the needed numbers of highly intelligent and motivated students to the practice of medicine. This in turn stymies the development of quality medical care, and the future acquisition and transmission of clinical knowledge. However, the recent violent events are a cruel reminder that China must make the rational delivery of compassionate, sophisticated medical-psychiatric care an absolute priority.

Keeping in mind that for the foreseeable future, the majority of mentally ill and emotionally distressed patients in China will continue to receive their care from general (non-specialist) doctors, what is the current situation in my own field of practice?

Chinese patients seeking expert help for mental distress will often receive care from physicians educated without any knowledge of available non-drug based treatment options, such as psychodynamic psychotherapy, group therapy and other types of behavioral interventions.

While in the West the set ways of medicine, and especially psychiatric medicine, are increasingly coming under critical scrutiny, most Chinese psychiatrists limit themselves to simplistic, obsolete interpretations of Western biomedical models that de-emphasize empathic listening.However, quality medical care, and especially mental health care, begins with a well-trained and experienced physician who is able to create a therapeutic alliance with a suffering and often frightened, and ashamed patient.

By contrast, the lack of time spent with an individual patient (when there are countless individuals waiting to be seen), combined with the economic reality of multiplying one’s salary by writing huge numbers of prescriptions puts Chinese doctors under undue and undeclared influence from extraneous forces, namely the pharmaceutical industry.

In turn, patients are at risk of receiving sub-optimal diagnosis and care and are put in harm’s way by medication overuse.

On a positive note, the Chinese government is taking steps to alleviate the existing income and infrastructure discrepancies between the Eastern coastal areas and the countryside, which will improve general medical, and one hopes, mental health care.

Equally important, a whole generation of sophisticated, highly motivated psychiatric physicians and non-medical psychotherapists is coming of age (in the big cities), educated in part thanks to outside efforts by not-for-profit organizations such as the Chinese American Psychoanalytic Alliance (CAPA).

Regarding the proposed health care reform, China might conclude that there is little synergy between corporate business models and her huge population’s need for accessible medical care.

The conflicts of interest that have come to shake US academia will need to be addressed here as well. At the same time, doctors’ working conditions must be improved. Eventually, consideration should be given to the establishment of a rational tort system that does not simply copy the excesses of the US system. There is much reason for hope and much work to be done. Chinese society, patients and doctors will be better off for it.

The author is a US educated neurologist and psychiatrist based in New York City, and a faculty member of Columbia University and the Chinese American Psychoanalytic Alliance.

(China Daily 07/05/2010 page8)

Posted in Psychiatry/Neurology |

Scientists Spot Gene Variants That Predict Longevity Grouping determined whether person lived to 100 with 77% accuracy

http://consumer.healthday.com/Article.asp?AID=640714

Posted in Aging |

A significant increase in polypharmacy involving antidepressant and antipsychotic medications.

Arch Gen Psychiatry. 2010 Jan;67(1):26-36.

National trends in psychotropic medication polypharmacy in office-based psychiatry.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Room 797, Baltimore, MD 21205, USA. rmojtaba@jhsph.edu

Abstract

CONTEXT: Psychotropic medication polypharmacy is common in psychiatric outpatient settings and, in some patient groups, may have increased in recent years. OBJECTIVE: To examine patterns and recent trends in psychotropic polypharmacy among visits to office-based psychiatrists. DESIGN: Annual data from the 1996-2006 cross-sectional National Ambulatory Medical Care Surveys were analyzed to examine patterns and trends in psychotropic polypharmacy within nationally representative samples of 13 079 visits to office-based psychiatrists. SETTING: Office-based psychiatry practices in the United States. PARTICIPANTS: Outpatients with mental disorder diagnoses visiting office-based psychiatrists. MAIN OUTCOME MEASURE: Number of medications prescribed in each visit and specific medication combinations. RESULTS: There was an increase in the number of psychotropic medications prescribed across years; visits with 2 or more medications increased from 42.6% in 1996-1997 to 59.8% in 2005-2006; visits with 3 or more medications increased from 16.9% to 33.2% (both P < .001). The median number of medications prescribed in each visit increased from 1 in 1996-1997 to 2 in 2005-2006 (mean increase: 40.1%). The increasing trend of psychotropic polypharmacy was mostly similar across visits by different patient groups and persisted after controlling for background characteristics. Prescription for 2 or more antidepressants, antipsychotics, sedative-hypnotics, and antidepressant-antipsychotic combinations, but not other combinations, significantly increased across survey years. There was no increase in prescription of mood stabilizer combinations. In multivariate analyses, the odds of receiving 2 or more antidepressants were significantly associated with a diagnosis of major depression (odds ratio [OR], 3.44; 99% confidence interval [CI], 2.58-4.58); 2 or more antipsychotics, with schizophrenia (OR, 6.75; 99% CI, 3.52-12.92); 2 or more mood stabilizers, with bipolar disorder (OR, 15.46; 99% CI, 6.77-35.31); and 2 or more sedative-hypnotics, with anxiety disorders (OR, 2.13; 99% CI, 1.41-3.22). CONCLUSIONS: There has been a recent significant increase in polypharmacy involving antidepressant and antipsychotic medications. While some of these combinations are supported by clinical trials, many are of unproven efficacy. These trends put patients at increased risk of drug-drug interactions with uncertain gains for quality of care and clinical outcomes.

PMID: 20048220 [PubMed – indexed for MEDLINE]
Posted in Psychiatry/Neurology |