Tag Archives: China
Fifth Avenue Concierge Medicine featured in 21 Century Business Insights, “the first and the leading Chinese Business Magazine in the U.S. market” (21CBIUS – 21世紀經濟導報)
Fifth Avenue Concierge Medicine, is very pleased to announce that 21 Century Business Insights, “the first and the leading Chinese Business Magazine in the U.S. market”, is featuring us in its October edition. Following a recent trend, 21 Century Business Insights (October … Continue reading
Week in China: Survey from China Youth Daily late last year found that 67% of respondents did not trust doctors’ diagnoses or recommended treatments
Survey from China Youth Daily late last year found that 67% of respondents did not trust doctors’ diagnoses or recommended treatments (a hefty 252,283 respondents took part, making it a pretty representative sample). Continue reading
N. Szajnberg, MD on “Lifelong opioidergic vulnerability through early life separation”
Bowlby was a careful observer. His entire volume on Loss spoke to the power of early childhood adversity and later life. More recently, a pediatric nephrologist at Kaiser in collaboration with others has shown that early childhood adversities, including loss, results in later adulthood medical ailments (Filetti et al); and Szajnberg and Massie followed Brodie’s cohort at thirty years to demonstrate this clinically.
Yet, Preter and Klein, citing the work of others, have shown pharmacological evidence of what appears to be a lifelong disorder in opiodergic systems due to childhood loss. Continue reading
Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.
“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading