Meta-analyses with industry involvement are massively published and report no caveats for antidepressants.

Posted on November 26, 2015 by Maurice Preter MD

CONCLUSION:

There is a massive production of meta-analyses of antidepressants for depression authored by or linked to the industry, and they almost never report any caveats about antidepressants in their abstracts. Our findings add a note of caution for meta-analyses with ties to the manufacturers of the assessed products. Continue reading →

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Serotonin and the marketing of a depression myth

Posted on October 10, 2015 by Maurice Preter MD

Serotonin and the marketing of a depression myth Serotonin and depression BMJ 2015; 350 doi: http://dx.doi.org.ezproxy.cul.columbia.edu/10.1136/bmj.h1771 (Published 21 April 2015)Cite this as: BMJ 2015;350:h1771  Article Related content Metrics Responses David Healy, professor of psychiatry Author affiliations david.healy54@googlemail.com The marketing of a myth The serotonin reuptake inhibiting … Continue reading →

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Benzodiazepine use and risk of Alzheimer’s disease

Posted on October 10, 2015 by Maurice Preter MD

Benzodiazepine use is associated with an increased risk of Alzheimer’s disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern. Continue reading →

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Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects.

Posted on June 26, 2015 by Maurice Preter MD

Neurology. 2005 May 24;64(10):1704-11. Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Enzinger C1, Fazekas F, Matthews PM, Ropele S, Schmidt H, Smith S, Schmidt R. Author information Abstract OBJECTIVES: To determine the rate of brain atrophy in neurologically asymptomatic elderly … Continue reading →

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“Noncognitive” symptoms of early Alzheimer disease

Posted on January 17, 2015 by Maurice Preter MD

Conclusions: We found a significantly earlier presence of positive symptoms on the NPI-Q in cognitively normal patients who subsequently developed CDR >0. Among participants with no depression symptoms at baseline, results suggest that depressive symptoms may increase with aging regardless of incipient dementia. Such findings begin to delineate the noncognitive course of Alzheimer disease dementia in the preclinical stages. Future research must further elucidate the correlation between noncognitive changes and distinct dementia subtypes. Continue reading →

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