Tag Archives: endogenous opioids
Young Adults’ Wallet Woes May Harm the Brain in Midlife
Young Adults’ Wallet Woes May Harm the Brain in Midlife -Findings emphasize how specific socioeconomic changes may negatively affect brain health by Zeena Nackerdien PhD, CME Writer, MedPage Today October 12, 2019 share to facebook share to twitter share to … Continue reading
A Proactive Response to Prescription Opioid Abuse
A Proactive Response to Prescription Opioid Abuse Robert M. Califf, M.D., Janet Woodcock, M.D., and Stephen Ostroff, M.D. February 4, 2016DOI: 10.1056/NEJMsr1601307 http://tinyurl.com/godfdoc We at the Food and Drug Administration (FDA) continue to be deeply concerned about the growing epidemic … Continue reading
New Book Alert: Panic Disorder: Neurobiological and Treatment Aspects
Panic Disorder/Psychiatry Home > Medicine > Psychiatry SUBDISCIPLINES JOURNALS BOOKS SERIES TEXTBOOKS REFERENCE WORKS Panic Disorder Neurobiological and Treatment Aspects Nardi, Antonio Egidio, Freire, Rafael Christophe R (Eds.) 2015, Approx. 300 p. 20 illus., 5 illus. in color. Available Formats: eBook Information Hardcover Information approx. $189.00 … Continue reading
Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions
Important paper on childhood adversities an adult-age chronic medical conditions, published just before our study on endogenous opioid dysregulation after early childhood adversity in psychiatrically and physically “healthy” adults. Archives of General Psychiatry August 2011, Vol 68, No. 8 > < Previous ArticleNext … Continue reading
Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.
“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading