Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

Posted on April 16, 2014 by Maurice Preter MD

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading →

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Metabolic features of the cell danger response. [Mitochondrion. 2013] – PubMed – NCBI

Posted on January 7, 2014 by Maurice Preter MD

This is a really exciting integrative paper on the (clinically and heuristically relevant) hot topic du jour: Inflammation.  I came across it when I was researching Tourette’s syndrome and inflammation – am seeing increasing numbers of patients without a good … Continue reading →

Posted in Complementary - Alternative Medicine, dietary, epigenetics, Events, Fifth Avenue Concierge Medicine, Health, keto, new treatments, News, Psychiatry/Neurology, Uncategorized | Tagged , , , , |

Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life

Posted on October 26, 2013 by Maurice Preter MD

Meta-Analyses: Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life. Another gem from Dr. Ken Pope’s web site.    

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A senior executive with Britain’s biggest drugs company has admitted that most prescription medicines do not work on most people who take them. Science – News – The Independent

Posted on October 21, 2013 by Maurice Preter MD

I just had the great pleasure of meeting Allen Roses. The 2003 article quoted is a reminder of “plus ca change, plus c’est la meme chose”. Glaxo chief: Our drugs do not work on most patients – Science – News … Continue reading →

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Among well-functioning older adults, DM and poor glucose control among those with DM are associated with worse cognitive function and greater decline. This suggests that severity of DM may contribute to accelerated cognitive aging.

Posted on September 7, 2013 by Maurice Preter MD

Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia. Yaffe K, et al. Show all Arch Neurol. 2012 Sep;69(9):1170-5. doi: 10.1001/archneurol.2012.1117. Affiliation Departments of Psychiatry, University of California, San Francisco, and San Francisco, VA, USA. kristine.yaffe@ucsf.edu Abstract … Continue reading →

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