Tag Archives: informed consent
Risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy
The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: A systematic review and meta-analysis http://onlinelibrary.wiley.com/doi/10.1111/bcp.12849/abstract Anick Bérard1,2,*, Noha Iessa1,2, Sonia Chaabane1,2, Flory T. Muanda1,2, Takoua Boukhris1,2 and Jin-Ping Zhao1,2 DOI: 10.1111/bcp.12849 This article … Continue reading →
Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease
Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease http://archinte.jamanetwork.com/article.aspx?articleid=2481157 Benjamin Lazarus, MBBS1,2; Yuan Chen, MS1; Francis P. Wilson, MD, MS3; Yingying Sang, MS1; Alex R. Chang, MD, MS4; Josef Coresh, MD, PhD1,5; Morgan E. Grams, MD, PhD1,5 [+] Author Affiliations JAMA Intern Med. Published online January 11, 2016. doi:10.1001/jamainternmed.2015.7193 Text Size: A A A … Continue reading →
Meta-analyses with industry involvement are massively published and report no caveats for antidepressants.
CONCLUSION:
There is a massive production of meta-analyses of antidepressants for depression authored by or linked to the industry, and they almost never report any caveats about antidepressants in their abstracts. Our findings add a note of caution for meta-analyses with ties to the manufacturers of the assessed products. Continue reading →
Benzodiazepine use and risk of Alzheimer’s disease
Benzodiazepine use is associated with an increased risk of Alzheimer’s disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern. Continue reading →
Benzodiazepine use associated with increased risk of dementia.
Conclusions In this prospective population based study, new use of benzodiazepines was associated with increased risk of dementia. The result was robust in pooled analyses across cohorts of new users of benzodiazepines throughout the study and in a complementary case-control study. Considering the extent to which benzodiazepines are prescribed and the number of potential adverse effects of this drug class in the general population, indiscriminate widespread use should be cautioned against. Continue reading →