Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Posted on February 18, 2019 by Maurice Preter MD

Fascinating. The Alzheimer Disease-infection connection is going mainstream. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors Stephen S. Dominy1,*,†, Casey Lynch1,*, Florian Ermini1, Malgorzata Benedyk2,3, Agata Marczyk2, Andrei Konradi1, Mai Nguyen1, Ursula Haditsch1, … Continue reading →

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Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes

Posted on February 18, 2019 by Maurice Preter MD

Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes Helena Mendes-Soares, PhD1,2; Tali Raveh-Sadka, PhD3; Shahar Azulay, BSc3; et alKim Edens, MSc1; Yatir Ben-Shlomo, BSc3; Yossi Cohen, MSc3; Tal Ofek, PhD3; Davidi Bachrach, BSc, MBA3; Josh Stevens, BSc3; Dorin Colibaseanu, MD2; Lihi Segal, LLB, MBA3; Purna Kashyap, MBBS1,4; Heidi Nelson, MD1,2 Author Affiliations Article Information JAMA Netw Open. 2019;2(2):e188102. … Continue reading →

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Systemic inflammation during midlife and cognitive change over 20 years The ARIC Study

Posted on February 18, 2019 by Maurice Preter MD

This is important. [Neuro]inflammation is long-term more damaging to cognition than high blood pressure. Many contributing factors: Metabolic syndrome, insomnia, noise pollution, traumatic brain injury, chronic poor relationships, poor self esteem, workplace bullying, socioeconomic distress etc.  Abstract Objective To examine … Continue reading →

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Serum homocysteine level is related to cerebral small vessel disease in a healthy population

Posted on January 21, 2019 by Maurice Preter MD

Prevention is easy and cheap. Abstract Objective To evaluate the relationship between serum total homocysteine (tHcy) levels and cerebral small vessel disease (cSVD) in a healthy population. Methods We included consecutive participants who visited our department for health checkups between … Continue reading →

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Many participants in AD clinical trials receiving ChEIs or memantine experience greater cognitive decline.

Posted on December 11, 2018 by Maurice Preter MD

Many participants in AD clinical trials receiving ChEIs or memantine experience greater cognitive decline. Original Investigation Neurology November 2, 2018 Association of Concomitant Use of Cholinesterase Inhibitors or Memantine With Cognitive Decline in Alzheimer Clinical TrialsA Meta-analysis Richard E. Kennedy, MD, PhD1; Gary … Continue reading →

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