Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

Posted on April 16, 2014 by Maurice Preter MD

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading →

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The Selling of Attention Deficit Disorder – NYTimes.com

Posted on December 15, 2013 by Maurice Preter MD

Surprisingly critical, thoroughly researched piece by Alan Schwarz. See also recent posts here (on opening the gigantic Asian market to Western psychotropics), here (on Allen Roses critique of drug efficacy), here (on the DSM V’s focus on, well, drug treatment), … Continue reading →

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Parental olfactory experience influences behavior and neural structure in subsequent generations : Nature Neuroscience

Posted on December 2, 2013 by Maurice Preter MD

Nature Neuroscience  Parental olfactory experience influences behavior and neural structure in subsequent generations Brian G Dias & Kerry J Ressler Affiliations Contributions Corresponding authors Nature Neuroscience (2013) doi:10.1038/nn.3594 Received 21 September 2013 Accepted 01 November 2013 Published online 01 December … Continue reading →

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Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life

Posted on October 26, 2013 by Maurice Preter MD

Meta-Analyses: Exercise’s Psychological & Physical Effects on Health, Disorders, & Quality of Life. Another gem from Dr. Ken Pope’s web site.    

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Metabolic Fate of Pharmaceuticals: A Focus on Slow Metabolizers

Posted on September 21, 2013 by Maurice Preter MD

Very interesting and timely PowerPoint focusing on (now increasingly preventable) adverse outcomes, not on metabolism-related lack of efficacy. >>It has been shown that variability in drug metabolism can have a substantial effect on clinical outcomes in patients. The impact of … Continue reading →

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