Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes

Posted on October 11, 2020 by Maurice Preter MD

Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study Katherine Samaras, Steve Makkar, John D. Crawford, Nicole A. Kochan, Wei Wen, Brian Draper, Julian … Continue reading →

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Posted on November 4, 2019 by Maurice Preter MD

Review  Volume 179, Issue 2, pp. 312-339, October 3, 2019 Justin M. Long David M. Holtzman References Article Info Published: September 26, 2019DOI:https://doi.org/10.1016/j.cell.2019.09.001 Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition … Continue reading →

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Alzheimer’s Drug Linked to Potentially Serious Muscle Condition

Posted on November 4, 2019 by Maurice Preter MD

  Megan Brooks September 19, 2019 The Alzheimer’s drug donepezil (multiple brands) is associated with a twofold higher risk for hospital admission for rhabdomyolysis, a rare but potentially life-threatening condition in which muscle cells break down. It can lead to kidney damage. … Continue reading →

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Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes

Posted on February 18, 2019 by Maurice Preter MD

Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes Helena Mendes-Soares, PhD1,2; Tali Raveh-Sadka, PhD3; Shahar Azulay, BSc3; et alKim Edens, MSc1; Yatir Ben-Shlomo, BSc3; Yossi Cohen, MSc3; Tal Ofek, PhD3; Davidi Bachrach, BSc, MBA3; Josh Stevens, BSc3; Dorin Colibaseanu, MD2; Lihi Segal, LLB, MBA3; Purna Kashyap, MBBS1,4; Heidi Nelson, MD1,2 Author Affiliations Article Information JAMA Netw Open. 2019;2(2):e188102. … Continue reading →

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Systemic inflammation during midlife and cognitive change over 20 years The ARIC Study

Posted on February 18, 2019 by Maurice Preter MD

This is important. [Neuro]inflammation is long-term more damaging to cognition than high blood pressure. Many contributing factors: Metabolic syndrome, insomnia, noise pollution, traumatic brain injury, chronic poor relationships, poor self esteem, workplace bullying, socioeconomic distress etc.  Abstract Objective To examine … Continue reading →

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