A senior executive with Britain’s biggest drugs company has admitted that most prescription medicines do not work on most people who take them. Science – News – The Independent

I just had the great pleasure of meeting Allen Roses. The 2003 article quoted is a reminder of “plus ca change, plus c’est la meme chose”. Glaxo chief: Our drugs do not work on most patients – Science – News … Continue reading

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Metabolic Fate of Pharmaceuticals: A Focus on Slow Metabolizers

Very interesting and timely PowerPoint focusing on (now increasingly preventable) adverse outcomes, not on metabolism-related lack of efficacy. >>It has been shown that variability in drug metabolism can have a substantial effect on clinical outcomes in patients. The impact of … Continue reading

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Simvastatin impairs exercise training adaptations.

Simvastatin impairs exercise training adaptations. Mikus CR, et al. Show all J Am Coll Cardiol. 2013 Aug 20;62(8):709-14. doi: 10.1016/j.jacc.2013.02.074. Epub 2013 Apr 10. Affiliation Division of Cardiology, Duke University Medical Center, Durham, North Carolina. Abstract OBJECTIVES: This study sought … Continue reading

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Long-term use of statins may be associated with increased risks of both ductal and lobular breast cancer among women 55-74 years of age

Search Home PDF Current Issue Past Issues OnlineFirst Long-term statin use and risk of ductal and lobular breast cancer among women 55-74 years of age  Authors Abstract Background: Mechanistic studies largely support the chemopreventive potential of statins. However, results of … Continue reading

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China ‘Catastrophe’ Hits 114 Million as Diabetes Spreads

Given the link between DM II and dementia, previous estimates of China’s coming dementia burden may need to be adjusted. See also: https://psychiatryneurology.net/news/time-to-confront-the-global-dementia-crisis-the-lancet-neurology/ >>The most comprehensive nationwide survey for diabetes ever conducted in China shows 11.6 percent of adults, or … Continue reading

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