Tag Archives: Panic
Preter Klein Panic disorder theory now available on PubMed Central (PMC)
[nihms] Manuscript #585187: Your manuscript is available in PMC Dear Maurice Preter, Manuscript NIHMS585187 (“Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder”) has been loaded into PubMed Central (PMC) … Continue reading
Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.
“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading
Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology? October 9, 2013 Mount Sinai Hospital, Department of Neurology Grand Rounds
Invitation to my Grand Rounds Talk at Mount Sinai, Wednesday, October 9, 2013, 8am
Please join us for our next Neurology Grand Rounds on Wednesday, October 9th at 8 AM in Davis Auditorium (Hess Center for Science and Medicine) at 1470 Madison Ave between 101st and 102nd streets. Refreshments will be served at 7:30 AM so please feel free to arrive early.
Title: “Panic, Separation Anxiety, Suffocation False Alarms and Endogenous Opioids: Can panic research inform clinical neurology?”
Presenter: Dr. Maurice Preter, MD
Assistant Professor of Clinical Psychiatry,
Columbia’s College of Physicians and Surgeons;
Associate Professor of Neurology (Adj.),
SUNY Downstate Medical Center, Brooklyn, NY
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An endogenous opioid deficiency/expanded suffocation false alarm theory model of panic disorder.
These are the slides from my talk at the First International Symposium on Translational Models of Panic Disorder. Vitoria, ES, Brazil, November 16-18, 2012.