Milk consumption and the risk of nigral degeneration

Milk consumption and the risk of nigral degeneration http://tinyurl.com/jomtju6 Honglei Chen, MD, PhD and Karen Marder, MD, MPH +SHOW AFFILIATIONS | + SHOW FULL DISCLOSURES Correspondence to Dr. Chen: chenh2@niehs.nih.gov Published online before print December 9, 2015, doi: http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000002268 Neurology February 9, … Continue reading

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Midlife milk consumption and substantia nigra neuron density at death

  Midlife milk consumption and substantia nigra neuron density at death http://tinyurl.com/jjwookb Robert D. Abbott, PhD, G. Webster Ross, MD, Helen Petrovitch, MD, Kamal H. Masaki, MD, Lenore J. Launer, PhD, James S. Nelson, MD, Lon R. White, MD and Caroline M. Tanner, MD, PhD +SHOW AFFILIATIONS | … Continue reading

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Accuracy of clinical diagnosis of Parkinson disease

Accuracy of clinical diagnosis of Parkinson disease http://tinyurl.com/jq9aakn A systematic review and meta-analysis Giovanni Rizzo, MD, Massimiliano Copetti, PhD, Simona Arcuti, PhD, Davide Martino, MD, Andrea Fontana, MScand Giancarlo Logroscino, MD +SHOW AFFILIATIONS + SHOW FULL DISCLOSURES Correspondence to Dr. Logroscino: giancarlo.logroscino@uniba.it Published online before print … Continue reading

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Neuroprotective and disease-modifying effects of the ketogenic diet

  Behav Pharmacol. 2006 Sep; 17(5-6): 431–439.  PMCID: PMC2367001 NIHMSID: NIHMS42857 Neuroprotective and disease-modifying effects of the ketogenic diet Maciej Gasior,a Michael A. Rogawski,a and  Adam L. Hartmana,b Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Behav Pharmacol … Continue reading

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Maurice Preter MD and Donald F. Klein, MD, DSc: Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder.

“[…W]e objectively, experimentally showed a physiological link between endogenous opioid system deficiency and panic-like suffocation sensitivity in healthy adults. This is consonant with the expanded Suffocation-False Alarm Theory of panic suggesting an episodic functional endogenous opioid deficit (Preter and Klein, 1998). The specificity of the naloxone + lactate model of clinical panic should be tested using specific anti-panic components, possibly including opioidergic mixed agonist-antagonists such as buprenorphine. If specific, the naloxone + lactate effect in normal humans affords a screening method for testing putative anti-panic drugs which is currently not available. This could obviate the experimental treatment of panic disorder patients in drug development.
Our data also show for the first time that actual separations and losses during childhood, such parental death, parental separation or divorce (CPL), effect lifelong alterations in the physiological reactivity of the endogenous opioid system of healthy adults.
This result encourages epigenetic inquiry into the effects of CPL on endogenous opioid systems, and their role in resilience under extreme stress. In addition, a redefinition of what constitutes a (truly) healthy control in clinical research protocols may be called for.” Continue reading

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