Tag Archives: Medication effects – wanted and unwanted

Panic Attacks and Panic Disorder – what is it and how can it be treated?

Panic Attacks and Panic Disorder – what is it and how can it be treated? Continue reading

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Alzheimer’s Disease – what is it and how can it be treated?

Alzheimer’s Disease – what is it and how can it be treated? Continue reading

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Dementia and Alzheimers’ Disease – How Can It Be Treated?

Dementia and Alzheimers’ Disease – How Can It Be Treated?

The Latin word “De-mentia”, literally means, the removal of a person from their own mind. It stands for a significant decrease in brain function, including memory, goal-directed thinking, orientation in space and time, and language ability.

Most dementias are progressive. They cannot be cured and will gradually cause more severe problems for the patient, and for the patient’s caretakers. As the population ages, Alzheimer’s disease is on its way to becoming the third most common fatal disease.

Prescription medications on the market starting in the 1990s to treat dementia have been a disappointment to patients and doctors alike.

The frustration caused by this situation prompted me to make the development of an anti-dementia treatment protocol a major focus of my clinical work.

As always, we start with a thorough neuropsychiatric assessment, looking for potentially reversible causes of cognitive decline such as a thyroid condition, vitamin deficiency, a sleep disorder, elevated blood sugar and diabetes. Importantly, untreated depression and chronic high stress and anxiety levels are associated with a higher risk for dementia. Most of the time, psychotherapy is a far better alternative to the all-too-common multiple prescription drugs.

The protocol uses a number of carefully evaluated novel interventions and components based on sound neuroscientific principles, sourced from both functional medicine and traditional medical systems, such as Ayurvedic and traditional Chinese medicine.

The protocol stabilizes many of my patients, and improves their functioning and quality of life. It has shown promising results not only for dementia, but also for traumatic brain injury. Continue reading

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Update on the treatment of Alzheimer’s Disease – from the International Conference of Parkinson Disease & Movement Disorders/MDS Developing World Education Program (DWEP). Shanghai First People’s Hospital, Jiao Tong University, Shanghai, PRC. September 30, 2016

Update on the treatment of Alzheimer’s Disease – from the International Conference of Parkinson Disease & Movement Disorders/MDS Developing World Education Program (DWEP). Shanghai First People’s Hospital, Jiao Tong University, Shanghai, PRC. September 30, 2016 Continue reading

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Overprescribing Anticholinergics May Hurt Recovery in Elderly

Overprescribing Anticholinergics May Hurt Recovery in Elderly http://news.psu.edu/story/389729/2016/01/28/research/anticholinergics-may-not-be-best-choice-rehab-patients-dementia UNIVERSITY PARK, Pa. — During rehabilitation following an acute hospital stay, medications that block neurotransmitters may be overprescribed to older patients suffering from delirium superimposed on dementia, according to health researchers. Specifically, strong anticholinergic medications may be prescribed to older adults when there are other suitable options. An anticholinergic medication blocks the neurotransmitter acetylcholine in the nervous system. These drugs are prescribed for a variety of symptoms, including incontinence, depression and insomnia. While their use can be … Continue reading

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Can Vitamin D Benefit Patients with Prediabetes?

Can Vitamin D Benefit Patients with Prediabetes? No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial Henrik Wagner1⇑, Michael Alvarsson1, Buster Mannheimer2, Marie Degerblad1 and Claes Göran Östenson1 http://care.diabetesjournals.org/content/early/2016/01/07/dc15 -1057.abstract Abstract OBJECTIVE There has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis. This study was designed to investigate the effect of high-dose vitamin D3 treatment on β-cell function, insulin sensitivity, and glucose tolerance in subjects with prediabetes or … Continue reading

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True Risk of Serious Harms with Antidepressants Still Uncertain

True Risk of Serious Harms with Antidepressants Still Uncertain http://www.bmj.com/content/352/bmj.i65 Abstract Objective To study serious harms associated with selective serotonin and serotonin-norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main outcome measures Mortality and suicidality. Secondary outcomes were aggressive behaviour and akathisia. Data sources Clinical study reports for duloxetine, fluoxetine, paroxetine, sertraline, and venlafaxine obtained from the European and UK drug regulators, and summary trial reports for duloxetine and fluoxetine from Eli Lilly’s website. Eligibility criteria for study selection Double blind placebo controlled trials that contained any patient narratives or … Continue reading

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Quetiapine safety in older adults?

Quetiapine safety in older adults? Journal of Clinical Pharmacy and Therapeutics Volume 41,  Issue 1, pages 7–18, February 2016 http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12357/abstract Abstract WHAT IS KNOWN AND OBJECTIVE: Quetiapine is a second-generation antipsychotic that is commonly prescribed for a range of approved and off-label indications in older adults. However, little is known about its safety in this population. The available evidence on quetiapine safety is based on studies on second-generation antipsychotics as a group, often in the general population and for approved indications. There are no systematicreviews on the safety … Continue reading

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Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition.

  Richard Carlton MD asked me to post abstracts related to the well-established but under-appreciated dopamine-blocking effect of metoclopramide. Ned Tijdschr Geneeskd. 2013;157(26):A6037. Severe parkinsonism due to Reglan (metoclopramide): the importance of early recognition. [Article in Dutch] de Ronde MW1, Kingma HJ, Munts AG. Author information 1Kennemer Gasthuis, afd. Neurologie, Haarlem, the Netherlands. mwjderonde@gmail.com Abstract In this article, we present 3 women aged 73, 85 and 88 years who developed metoclopramide-induced parkinsonism. Shortly after starting metoclopramide, bradykinesia and rigidity developed in all 3 patients; tremor and postural instability … Continue reading

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Risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy

The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: A systematic review and meta-analysis   http://onlinelibrary.wiley.com/doi/10.1111/bcp.12849/abstract Anick Bérard1,2,*, Noha Iessa1,2, Sonia Chaabane1,2, Flory T. Muanda1,2, Takoua Boukhris1,2 and Jin-Ping Zhao1,2 DOI: 10.1111/bcp.12849 This article is protected by copyright. All rights reserved. Issue British Journal of Clinical Pharmacology Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) Additional Information(Show All) Author InformationPublication History This article has been accepted for … Continue reading

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Meta-analyses with industry involvement are massively published and report no caveats for antidepressants.

CONCLUSION:

There is a massive production of meta-analyses of antidepressants for depression authored by or linked to the industry, and they almost never report any caveats about antidepressants in their abstracts. Our findings add a note of caution for meta-analyses with ties to the manufacturers of the assessed products. Continue reading

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Serotonin and the marketing of a depression myth

Serotonin and the marketing of a depression myth Serotonin and depression BMJ 2015; 350 doi: http://dx.doi.org.ezproxy.cul.columbia.edu/10.1136/bmj.h1771 (Published 21 April 2015)Cite this as: BMJ 2015;350:h1771  Article Related content Metrics Responses David Healy, professor of psychiatry Author affiliations david.healy54@googlemail.com The marketing of a myth The serotonin reuptake inhibiting (SSRI) group of drugs came on stream in the late 1980s, nearly two decades after first being mooted. The delay centred on finding an indication. They did not have hoped for lucrative antihypertensive or antiobesity profiles. A 1960s idea that serotonin concentrations might be lowered … Continue reading

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