BMJ.org: Research News Benzodiazepines may be linked to Alzheimer’s disease, study finds

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Benzodiazepines may be linked to Alzheimer’s disease, study finds

BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g5555 (Published 10 September 2014)Cite this as: BMJ 2014;349:g5555

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  1. Zosia Kmietowicz

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Taking benzodiazepines is associated with an increased risk of developing Alzheimer’s disease, particularly in long term users, a study has found.

Benzodiazepine use has long been associated with an increased risk of Alzheimer’s disease, although whether this association is causal remains unclear. To try to better understand the association, a team of researchers from France and Canada used data from the Quebec health insurance programme database (RAMQ) to track the development of Alzheimer’s in a sample of elderly residents living in Quebec, Canada, who had been prescribed benzodiazepines.1

Over a period of at least six years they identified 1796 cases of Alzheimer’s disease. They then compared these cases …

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Mysterious disease in Kazakhstan – A new von Economo encephalitis, post-vaccine, or mass hysteria?

Perhaps of note, Kalachi was one of the USSR’s “secret cities” (an uranium mine).

Mysterious disease in Kazakhstan resembles plot of X-Files series

10 SEPTEMBER 2014, 10:49 (GMT+05:00)
Photo: Mysterious disease in Kazakhstan resembles plot of X-Files series / Kazakhstan

Baku, Azerbaijan, Sept. 10

By Elena Kosolapova – Trend: The story developing in a small settlement in northern Kazakhstan is worthy of a plot for popular American science fiction television drama series, “The X-Files.”

The residents of the Kazakh village of Kalachi are racking with a mysterious disease that could not be explained by a wide range of specialists in medicine and many other specialized fields.

The villagers complain of severe fatigue and constant desire to sleep. They can suddenly fall asleep in the most unexpected places – at work, at school, in the street – and sleep for several days. Nobody and nothing can wake them up. And after waking up some of them lose memory, have hallucinations, and behave like in a dream.

The first case of the manifestation of this sleeping disease occurred in Kalachi in March 2013. And the disease breaks out once every few months. Ten percent of the village population exceeding 600 people has been infected with this disease.

The strangest thing that despite the authorities’ investigation with the involvement of local and invited specialists, the cause of the sickness remains a mystery. The scientists conducted thousands of experiments on soil, air and water in the village and the diseased patients, but the only thing they could say the people are quite healthy and the symptoms they experience do not fit into any of the known diseases.

Some kind of sleeping sickness, which also called “human African trypanosomiasis,” is a widespread tropical disease. But besides permanent desire to sleep the symptoms of this disease are different. Moreover African disease is spread by a bite of an infected tsetse fly living dozens of thousands kilometers far from Kazakhstan. And bacteriological and viral tests on Kalachi’s villagers have proved negative.
Local people are in despair. They think the authorities are hiding the truth about the disease and invent a number of fantastic explanations of its reasons from biology experiments conducted by western laboratories to aliens and God’s punishment.

However there are some versions which are more real at first glance. Kalachi is located in the vicinity of former Soviet secret uranium mining town Krasnogorsk, which was closed after Soviet Union’s collapse about 20 years ago. Some people associate abnormal sleep with the abandoned uranium mine. But scientists working at the scene say that the radiation level is normal across the village. Moreover the unfortunate Kalachi is the only village affected by this strange sickness and the dwellers of other settlements located nearby and even those who worked in the uranium mine for all their life are safe and sound.

Local nuclear specialists also assure that radiation sickness does not produce sleeping effects. Western experts share their opinion on this issue.
“In my work so far I have never heard of radiation causing any sleeping disease,” Britt-Marie Drottz Sjoberg, psychology professor at the Norwegian University of Science and Technology who has lead and participated in a number of researches and projects relation to public reactions to radiation, radioactive waste and environmental issues told Trend by e-mail.

“I doubt that uranium is the cause of the sleeping sickness… There is no such thing as “normal” for radiation levels… they should be published and compared to places without uranium mining operations,” Janette Sherman, M.D. specializing in internal medicine and toxicology with an emphasis on chemicals and nuclear radiation who earlier worked for the Atomic Energy Commission at the University of California in Berkeley, and for the U.S. Navy Radiation Defense Laboratory in San Francisco and published a number of researches on nuclear radiation also told Trend by e-mail.

Now all the people suffering from the disease in Kalachi are diagnosed with encephalopathy of unknown origin, i.e. brain damage by unknown substance. The substance was not defined.

Kazakh Health Ministry informed that the disease had classic signs of narcolepsy and some psychologists and psychiatrists explain the disease by massive psychosis.

“There have been many such unexplained events. Some of them have been caused by agents such as virus that were discovered later, such as von economo encephalitis, others by vaccines, most have been unexplained medically and assumed to be mass hysteria,” Maurice Preter, M.D., Assistant Professor of Clinical Psychiatry on the faculty of Columbia University’s College of Physicians & Surgeons and is Adj. Associate Professor of Neurology at SUNY Downstate Medical Center told Trend by e-mail.

A special commission was created from specialists from several Kazakh ministries to investigate the situation in Kalachi. But the only problem revealed by the commission in the village so far was the higher level of radon gas in air. This gas used in anesthesiology could be the cause of the abnormal sleep, according one of the numerous versions, the scientists say. However the commission does not announce when the investigation is expected to be completed.

Meanwhile extrasensory individuals, sorcerers and ufologists explain the disease by weird by extraterrestrial reasons.

The last wave of the mysterious disease happened on September 1. Nine children fell asleep immediately after festive ceremony on the occasion of new academic year and slept for two days. And this time the patients’ symptoms have aggravated compared to the last year. The diseased people have nightmares, hallucinations and some signs of insanity. Thus, the problem requires prompt solution and should not be delayed. Maybe the truth is out there.

Edited by C.S.

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Neurology.org: Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults

Sleep and cognitive status is a developing hot topic. When will hospitals have to assure a peaceful, uninterrupted night for inpatients?

Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults
  1. Claire E. Sexton, DPhil,
  2. Andreas B. Storsve, MSc,
  3. Kristine B. Walhovd, PhD,
  4. Heidi Johansen-Berg, DPhil and
  5. Anders M. Fjell, PhD

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  1. Correspondence to Dr. Sexton: claire.sexton@ndcn.ox.ac.uk
  1. Published online before print September 3, 2014, doi: 10.1212/WNL.0000000000000774Neurology September 9, 2014 vol. 83 no. 11 967-973

ABSTRACT

Objective: To examine the relationship between sleep quality and cortical and hippocampal volume and atrophy within a community-based sample, explore the influence of age on results, and assess the possible confounding effects of physical activity levels, body mass index (BMI), and blood pressure.

Methods: In 147 community-dwelling adults (92 female; age 53.9 ± 15.5 years), sleep quality was measured using the Pittsburgh Sleep Quality Index and correlated with cross-sectional measures of volume and longitudinal measures of atrophy derived from MRI scans separated by an average of 3.5 years. Exploratory post hoc analysis compared correlations between different age groups and included physical activity, BMI, and blood pressure as additional covariates.

Results: Poor sleep quality was associated with reduced volume within the right superior frontal cortex in cross-sectional analyses, and an increased rate of atrophy within widespread frontal, temporal, and parietal regions in longitudinal analyses. Results were largely driven by correlations within adults over the age of 60, and could not be explained by variation in physical activity, BMI, or blood pressure. Sleep quality was not associated with hippocampal volume or atrophy.

Conclusions: We found that longitudinal measures of cortical atrophy were widely correlated with sleep quality. Poor sleep quality may be a cause or a consequence of brain atrophy, and future studies examining the effect of interventions that improve sleep quality on rates of atrophy may hold key insights into the direction of this relationship.

FOOTNOTES

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Supplemental data at Neurology.org

  • Received February 10, 2014.
  • Accepted in final form June 12, 2014.
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Salt intake is associated with inflammation in chronic heart failure.

Int Cardiovasc Res J. 2014 Sep;8(3):89-93. Epub 2014 Sep 1.

Salt intake is associated with inflammation in chronic heart failure.

Abstract

BACKGROUND:

Chronic Heart Failure (CHF) is highly prevalent and is associated with high morbidity and mortality rates. It has been well established that excessive intake of sodium chloride (salt) induced hypertension in some populations. Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseases independently from blood pressure elevation.

OBJECTIVES:

The present study aimed to evaluate the association between salt consumption and inflammation in CHF patients.

PATIENTS AND METHODS:

This study was conducted on 86 patients between 18 and 65 years old who were diagnosed with New York HeartAssociation (NYHA) functional class I and II heart failure. Salt intake was calculated by using 24 hour urine sodium excretion. Besides, the association between inflammation and daily salt intake was evaluated regarding C – reactive protein (CPR), High sensitive CRP (HsCPR), Erythrocyte Sedimentation Rate (ESR), and ferritin and fibrinogen levels using Pearson correlation analysis.

RESULTS:

Our results showed a statistically significant difference between the low (n = 41) and high (n = 45) salt intake groups in terms of serum HsCRP levels (5.21 ± 2.62 vs. 6.36 ± 2.64) (P < 0.048). Additionally, a significant correlation was observed between the amount of salt consumption and HsCRP levels. In this study, daily salt consumption of the enrolled patients was 8.53 gram/day. The medications and even the blood pressures were similar in the two groups, but daily pill count, prevalence of hypertension, and coronary heart disease were higher in the high salt intake group; however, the differences were not statistically significant (P = 0.065). Also, no significant difference was observed between the groups concerning the inflammation markers, such as CRP, ESR, ferritin, and fibrinogen.

CONCLUSIONS:

Neurohumoral and inflammatory factors are thought to contribute to high mortality and morbidity rates in CHF. Yet, inflammatory markers may early diagnose CHF and predict the prognosis. Excessive salt intake also worsens the inflammation as well as volume control.

KEYWORDS:

Heart Failure; Inflammation; Sodium Dietary

PMID:

 

25177670

 

[PubMed] 
PMCID:

 

PMC4109042

 

Free PMC Article

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Neurology.org: Vitamin D and the risk of dementia and Alzheimer disease

 

OPEN ACCESS ARTICLE

Vitamin D and the risk of dementia and Alzheimer disease

  1. Thomas J. Littlejohns, MSc,
  2. William E. Henley, PhD,
  3. Iain A. Lang, PhD,
  4. Cedric Annweiler, MD, PhD,
  5. Olivier Beauchet, MD, PhD,
  6. Paulo H.M. Chaves, MD, PhD,
  7. Linda Fried, MD, MPH,
  8. Bryan R. Kestenbaum, MD, MS,
  9. Lewis H. Kuller, MD, DrPH,
  10. Kenneth M. Langa, MD, PhD,
  11. Oscar L. Lopez, MD,
  12. Katarina Kos, MD, PhD,
  13. Maya Soni, PhD*and
  14. David J. Llewellyn, PhD*

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  1. Correspondence to Dr. Llewellyn: david.llewellyn@exeter.ac.uk
  1. Published online before print August 6, 2014, doi: 10.1212/WNL.0000000000000755Neurology September 2, 2014 vol. 83 no. 10 920-928
  1. Also available:
  2. Figures Only
  3. Data Supplement
  4. PPT Slides of All Figures

ABSTRACT

Objective: To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease.

Methods: One thousand six hundred fifty-eight elderly ambulatory adults free from dementia, cardiovascular disease, and stroke who participated in the US population–based Cardiovascular Health Study between 1992–1993 and 1999 were included. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected in 1992–1993. Incident all-cause dementia and Alzheimer disease status were assessed during follow-up using National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria.

Results: During a mean follow-up of 5.6 years, 171 participants developed all-cause dementia, including 102 cases of Alzheimer disease. Using Cox proportional hazards models, the multivariate adjusted hazard ratios (95% confidence interval [CI]) for incident all-cause dementia in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25 to <50 nmol/L) were 2.25 (95% CI: 1.23–4.13) and 1.53 (95% CI: 1.06–2.21) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted hazard ratios for incident Alzheimer disease in participants who were severely 25(OH)D deficient and deficient compared to participants with sufficient concentrations were 2.22 (95% CI: 1.02–4.83) and 1.69 (95% CI: 1.06–2.69). In multivariate adjusted penalized smoothing spline plots, the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L.

Conclusion: Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.

FOOTNOTES

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was paid by The National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South West Peninsula.

  • * These authors contributed equally to the manuscript.

  • Supplemental data at Neurology.org

  • Received February 3, 2014.
  • Accepted in final form May 28, 2014.

This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

RESPONSES TO THIS ARTICLE

  • Vitamin D deficiency and the risk of dementia

    • Robert H Howland

    published online August 28, 2014

  • Disturbed sleep: the trigger for vitamin D deficiency?

    • Sergio Tufik

    published online August 14, 2014

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